ID   T178A_XENLA             Reviewed;         304 AA.
AC   Q5XGU1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Transmembrane protein 178A;
DE   Flags: Precursor;
GN   Name=tmem178a; Synonyms=tmem178.1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a negative regulator of osteoclast
CC       differentiation. {ECO:0000250|UniProtKB:Q9CZ16}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9CZ16}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM178 family. {ECO:0000305}.
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DR   EMBL; BC084338; AAH84338.1; -; mRNA.
DR   RefSeq; NP_001088305.1; NM_001094836.1.
DR   AlphaFoldDB; Q5XGU1; -.
DR   DNASU; 495141; -.
DR   GeneID; 495141; -.
DR   KEGG; xla:495141; -.
DR   CTD; 495141; -.
DR   Xenbase; XB-GENE-942690; tmem178a.S.
DR   OMA; LFCAWCS; -.
DR   OrthoDB; 1336222at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 495141; Expressed in brain and 11 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR039625; T178A/B.
DR   PANTHER; PTHR32005; PTHR32005; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..304
FT                   /note="Transmembrane protein 178A"
FT                   /id="PRO_0000287284"
FT   TOPO_DOM        26..186
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        208..215
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        237..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..304
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   304 AA;  34065 MW;  DBD7876BE9B79E2E CRC64;
     MESRGLVTAV SLTLSICSLL LLVTAIFTDH WYETDTRKHK EMCDSQGNSD PTEQKNRLMP
     LYQLPFRGDP SNTRRLGLLS PAPAGGVREP EDLLENWRSL LGLGVLESDC GRPLFSTYSG
     LWRKCYIMGI DKDIDSLIIK GIAQKCTAIK YHFSHPIRLR NIPFNLTRAI QQDEWHLLHL
     RRITAGFLGM AAAVLLCGCI VAAISFFWEE SLTQHVAGLL FLMTGIFCTI SLCTYAASVA
     YELNRQPKFI YGLPSDVEHG YSWSLFCAWC SLGLIVAAGC LCTAYPFISR TKILHLKFAR
     DSCV