T178B_DANRE
ID T178B_DANRE Reviewed; 294 AA.
AC Q1L8F4; A7E2P1; Q6DGZ4;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Transmembrane protein 178B;
DE Flags: Precursor;
GN Name=tmem178b; ORFNames=zgc:92710;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM178 family. {ECO:0000305}.
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DR EMBL; BX005210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR792454; CAK05026.1; -; Genomic_DNA.
DR EMBL; BC150449; AAI50450.1; -; mRNA.
DR EMBL; BC076190; AAH76190.1; -; mRNA.
DR RefSeq; NP_001002396.2; NM_001002396.2.
DR AlphaFoldDB; Q1L8F4; -.
DR STRING; 7955.ENSDARP00000036408; -.
DR PaxDb; Q1L8F4; -.
DR Ensembl; ENSDART00000036779; ENSDARP00000036408; ENSDARG00000006747.
DR Ensembl; ENSDART00000182399; ENSDARP00000154510; ENSDARG00000006747.
DR GeneID; 436669; -.
DR KEGG; dre:436669; -.
DR CTD; 100507421; -.
DR ZFIN; ZDB-GENE-040718-92; tmem178bb.
DR eggNOG; ENOG502QSX0; Eukaryota.
DR GeneTree; ENSGT00390000015299; -.
DR HOGENOM; CLU_961492_0_0_1; -.
DR InParanoid; Q1L8F4; -.
DR OMA; WSKCHRL; -.
DR OrthoDB; 1336222at2759; -.
DR PhylomeDB; Q1L8F4; -.
DR TreeFam; TF331307; -.
DR PRO; PR:Q1L8F4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000006747; Expressed in retina and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR039625; T178A/B.
DR PANTHER; PTHR32005; PTHR32005; 1.
DR Pfam; PF13903; Claudin_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..294
FT /note="Transmembrane protein 178B"
FT /id="PRO_0000419262"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 140
FT /note="Y -> C (in Ref. 2; AAI50450)"
FT /evidence="ECO:0000305"
FT CONFLICT 243
FT /note="D -> G (in Ref. 2; AAH76190)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 294 AA; 33297 MW; 7834A6157834DEA4 CRC64;
MAAGKLLLYA GLSLSLCALG MLAVAICSDH WYETDARRYR ERCRSFSSRR KDPGFIYIPN
NSLPLRASRS RLDRWEEKLL LARNRRQLFA MSAADECSKR YNSTNMGLWS KCHRLGFDQE
IEDLIRNGSI ARCSYIKYHY SSATIPKDLS YNITKTIRQD EWHSLHLRRM TAGFMGMAVA
IILFGWIIGM LGCCWDRGLM QYVAGLLFLM GGTFCIISLC TCVAGINFEL SRYPRYIYGL
PDDISHGYGW SMFCAWGGLG LSLIAGFFCT LAPSVQPIPR STCPKSRQEN GTVC
