T178B_HUMAN
ID T178B_HUMAN Reviewed; 294 AA.
AC H3BS89;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Transmembrane protein 178B;
DE Flags: Precursor;
GN Name=TMEM178B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-142.
RC TISSUE=Brain;
RA Ebert L., Heil O., Hennig S., Neubert P., Partsch E., Peters M.,
RA Radelof U., Schneider D., Korn B.;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM178 family. {ECO:0000305}.
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DR EMBL; AC004928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX114205; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59086.1; -.
DR RefSeq; NP_001182207.1; NM_001195278.1.
DR AlphaFoldDB; H3BS89; -.
DR BioGRID; 934125; 2.
DR IntAct; H3BS89; 2.
DR STRING; 9606.ENSP00000456594; -.
DR GlyGen; H3BS89; 2 sites.
DR iPTMnet; H3BS89; -.
DR PhosphoSitePlus; H3BS89; -.
DR BioMuta; TMEM178B; -.
DR jPOST; H3BS89; -.
DR MassIVE; H3BS89; -.
DR PaxDb; H3BS89; -.
DR PeptideAtlas; H3BS89; -.
DR PRIDE; H3BS89; -.
DR Antibodypedia; 63825; 4 antibodies from 4 providers.
DR DNASU; 100507421; -.
DR Ensembl; ENST00000565468.6; ENSP00000456594.1; ENSG00000261115.7.
DR GeneID; 100507421; -.
DR KEGG; hsa:100507421; -.
DR MANE-Select; ENST00000565468.6; ENSP00000456594.1; NM_001195278.2; NP_001182207.1.
DR UCSC; uc003vwg.3; human.
DR CTD; 100507421; -.
DR DisGeNET; 100507421; -.
DR GeneCards; TMEM178B; -.
DR HGNC; HGNC:44112; TMEM178B.
DR HPA; ENSG00000261115; Tissue enhanced (heart muscle, parathyroid gland, tongue).
DR neXtProt; NX_H3BS89; -.
DR OpenTargets; ENSG00000261115; -.
DR VEuPathDB; HostDB:ENSG00000261115; -.
DR eggNOG; ENOG502QSX0; Eukaryota.
DR GeneTree; ENSGT00390000015299; -.
DR HOGENOM; CLU_961492_0_0_1; -.
DR InParanoid; H3BS89; -.
DR OMA; WSKCHRL; -.
DR OrthoDB; 1336222at2759; -.
DR PhylomeDB; H3BS89; -.
DR PathwayCommons; H3BS89; -.
DR SignaLink; H3BS89; -.
DR BioGRID-ORCS; 100507421; 16 hits in 1063 CRISPR screens.
DR ChiTaRS; TMEM178B; human.
DR Pharos; H3BS89; Tdark.
DR PRO; PR:H3BS89; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; H3BS89; protein.
DR Bgee; ENSG00000261115; Expressed in cardiac muscle of right atrium and 150 other tissues.
DR ExpressionAtlas; H3BS89; baseline and differential.
DR Genevisible; H3BS89; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR039625; T178A/B.
DR PANTHER; PTHR32005; PTHR32005; 1.
DR Pfam; PF13903; Claudin_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..294
FT /note="Transmembrane protein 178B"
FT /id="PRO_0000419261"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 294 AA; 33409 MW; D13DE2CDF3F949C4 CRC64;
MAAGRLLLYT GLSLALCALG MLAVAICSDH WYETDARKHR DRCKAFNTRR VDPGFIYNNN
NNLPLRASRS RLDRWEGKLL RARNRRQLFA MSPADECSRQ YNSTNMGLWR KCHRQGFDPE
IAALIRKGEI ERCTYIKYHY SSATIPRNLT FNITKTIRQD EWHALHLRRM TAGFMGMAVA
IILFGWIIGV LGCCWDRGLM QYVAGLLFLM GGTFCIISLC TCVAGINFEL SRYPRYLYGL
PDDISHGYGW SMFCAWGGLG LTLISGFFCT LAPSVQPVPR TNYPKSRPEN GTVC
