ID   T178B_XENTR             Reviewed;         314 AA.
AC   F6V1J6; Q6NX20;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Transmembrane protein 178B;
DE   Flags: Precursor;
GN   Name=tmem178b; Synonyms=tmem178.2; ORFNames=TNeu089c06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM178 family. {ECO:0000305}.
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DR   EMBL; CR926218; CAJ82608.1; -; mRNA.
DR   EMBL; AAMC01121757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01121758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01121759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC067318; AAH67318.1; -; mRNA.
DR   RefSeq; NP_001001190.1; NM_001001190.1.
DR   AlphaFoldDB; F6V1J6; -.
DR   PaxDb; F6V1J6; -.
DR   DNASU; 407851; -.
DR   Ensembl; ENSXETT00000017361; ENSXETP00000017361; ENSXETG00000007915.
DR   GeneID; 407851; -.
DR   KEGG; xtr:407851; -.
DR   CTD; 407851; -.
DR   Xenbase; XB-GENE-5809007; tmem178.2.
DR   eggNOG; ENOG502QSX0; Eukaryota.
DR   HOGENOM; CLU_961492_0_0_1; -.
DR   InParanoid; F6V1J6; -.
DR   OrthoDB; 1336222at2759; -.
DR   PhylomeDB; F6V1J6; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000007915; Expressed in brain and 10 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR039625; T178A/B.
DR   PANTHER; PTHR32005; PTHR32005; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..314
FT                   /note="Transmembrane protein 178B"
FT                   /id="PRO_0000419263"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          32..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  34672 MW;  DEBD7F795CA4BFE0 CRC64;
     MRLLAGAGLC LALAALALLA VALSTDHWYE TDARRHRDRC RKPGGKRNDP GYMYTPGQHL
     PLRGEPPSSR IRSPRGGEPG GVRMISRAED LGVRGLRERP TGARDLPLSR PYLATDPHCS
     RRFNSTVSGL WRKCHRDGFD KDTEELILKG IVERCTSVRY YYTSSSLPPN LSVNVTKTIR
     QDEWHALHLR RMTAGFIGMA VSIILFGWMV GVLGCCKQHD LMQYVAGLLF LMGGTCCIIS
     LCTCVAGINF ELSRYPRSIY SLPEEISHGY GWSMFCAWGG LGLTLLSGFL CTLAPSLSAS
     QSAVHKPRQE NGAV