T179A_HUMAN
ID T179A_HUMAN Reviewed; 233 AA.
AC Q6ZVK1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Transmembrane protein 179;
DE AltName: Full=Transmembrane protein 179A;
GN Name=TMEM179; Synonyms=C14orf90, TMEM179A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZVK1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZVK1-2; Sequence=VSP_021227, VSP_021228;
CC -!- SIMILARITY: Belongs to the TMEM179 family. {ECO:0000305}.
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DR EMBL; AK124477; BAC85860.1; -; mRNA.
DR EMBL; BX927359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS66723.1; -. [Q6ZVK1-1]
DR RefSeq; NP_001273318.1; NM_001286389.1. [Q6ZVK1-1]
DR RefSeq; NP_001273319.1; NM_001286390.1.
DR AlphaFoldDB; Q6ZVK1; -.
DR STRING; 9606.ENSP00000450958; -.
DR TCDB; 9.B.201.1.1; the 4 tms tmem179 (tmem179) family.
DR GlyGen; Q6ZVK1; 1 site.
DR iPTMnet; Q6ZVK1; -.
DR PhosphoSitePlus; Q6ZVK1; -.
DR BioMuta; TMEM179; -.
DR DMDM; 126229230; -.
DR MassIVE; Q6ZVK1; -.
DR MaxQB; Q6ZVK1; -.
DR PaxDb; Q6ZVK1; -.
DR PeptideAtlas; Q6ZVK1; -.
DR PRIDE; Q6ZVK1; -.
DR ProteomicsDB; 68419; -. [Q6ZVK1-1]
DR Antibodypedia; 62288; 3 antibodies from 3 providers.
DR DNASU; 388021; -.
DR Ensembl; ENST00000341595.7; ENSP00000340477.3; ENSG00000258986.7. [Q6ZVK1-2]
DR Ensembl; ENST00000556573.6; ENSP00000450958.1; ENSG00000258986.7. [Q6ZVK1-1]
DR Ensembl; ENST00000625335.2; ENSP00000487568.1; ENSG00000276342.4. [Q6ZVK1-2]
DR Ensembl; ENST00000630378.2; ENSP00000485891.1; ENSG00000276342.4. [Q6ZVK1-1]
DR GeneID; 388021; -.
DR KEGG; hsa:388021; -.
DR MANE-Select; ENST00000556573.6; ENSP00000450958.1; NM_001286389.2; NP_001273318.1.
DR UCSC; uc001yox.3; human. [Q6ZVK1-1]
DR CTD; 388021; -.
DR DisGeNET; 388021; -.
DR GeneCards; TMEM179; -.
DR HGNC; HGNC:20137; TMEM179.
DR HPA; ENSG00000258986; Group enriched (brain, pituitary gland).
DR neXtProt; NX_Q6ZVK1; -.
DR OpenTargets; ENSG00000258986; -.
DR PharmGKB; PA162405995; -.
DR VEuPathDB; HostDB:ENSG00000258986; -.
DR eggNOG; ENOG502QW4U; Eukaryota.
DR GeneTree; ENSGT00510000048283; -.
DR HOGENOM; CLU_103794_0_0_1; -.
DR InParanoid; Q6ZVK1; -.
DR OMA; DEFRGHC; -.
DR OrthoDB; 1596832at2759; -.
DR PhylomeDB; Q6ZVK1; -.
DR TreeFam; TF324841; -.
DR PathwayCommons; Q6ZVK1; -.
DR BioGRID-ORCS; 388021; 11 hits in 1056 CRISPR screens.
DR ChiTaRS; TMEM179; human.
DR GenomeRNAi; 388021; -.
DR Pharos; Q6ZVK1; Tdark.
DR PRO; PR:Q6ZVK1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q6ZVK1; protein.
DR Bgee; ENSG00000258986; Expressed in hypothalamus and 86 other tissues.
DR ExpressionAtlas; Q6ZVK1; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029673; TMEM179.
DR PANTHER; PTHR31872; PTHR31872; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..233
FT /note="Transmembrane protein 179"
FT /id="PRO_0000254552"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 175..202
FT /note="FGLWASWLAWLAITTLAFLKVYHNYRQE -> VGGSGQEGRLAMLGGGHLLL
FT DIC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021227"
FT VAR_SEQ 203..233
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021228"
SQ SEQUENCE 233 AA; 26378 MW; 8F2A598321FB0134 CRC64;
MALNNFLFAQ CACYFLAFLF SFVVVVPLSE NGHDFRGRCL LFTEGMWLSA NLTVQERERF
TVQEWGPPAA CRFSLLASLL SLLLAAAHAW RTLFFLCKGH EGSFFSAFLN LLVSAFVVFL
VFIASTIVSV GFTMWCDTIT EKGTVPHSCE ELQDIDLELG VDNSAFYDQF AIAQFGLWAS
WLAWLAITTL AFLKVYHNYR QEDLLDSLIH EKELLLARPS PRTSFQEEKS AVI
