T179A_MOUSE
ID T179A_MOUSE Reviewed; 233 AA.
AC Q8BHH9; Q78GD2; Q7TPP8; Q8BN09;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Transmembrane protein 179;
GN Name=Tmem179;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, Hippocampus, and Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM179 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC41142.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK044254; BAC31841.1; -; mRNA.
DR EMBL; AK049973; BAC34012.1; -; mRNA.
DR EMBL; AK090230; BAC41142.1; ALT_FRAME; mRNA.
DR EMBL; BC046482; AAH46482.3; -; mRNA.
DR EMBL; BC055014; AAH55014.2; -; mRNA.
DR CCDS; CCDS36570.1; -.
DR RefSeq; NP_849246.2; NM_178915.3.
DR AlphaFoldDB; Q8BHH9; -.
DR STRING; 10090.ENSMUSP00000068004; -.
DR GlyGen; Q8BHH9; 1 site.
DR iPTMnet; Q8BHH9; -.
DR PhosphoSitePlus; Q8BHH9; -.
DR PaxDb; Q8BHH9; -.
DR PRIDE; Q8BHH9; -.
DR ProteomicsDB; 254526; -.
DR Antibodypedia; 62288; 3 antibodies from 3 providers.
DR DNASU; 104885; -.
DR Ensembl; ENSMUST00000066791; ENSMUSP00000068004; ENSMUSG00000054013.
DR GeneID; 104885; -.
DR KEGG; mmu:104885; -.
DR UCSC; uc007per.1; mouse.
DR CTD; 388021; -.
DR MGI; MGI:2144891; Tmem179.
DR VEuPathDB; HostDB:ENSMUSG00000054013; -.
DR eggNOG; ENOG502QW4U; Eukaryota.
DR GeneTree; ENSGT00510000048283; -.
DR HOGENOM; CLU_103794_0_0_1; -.
DR InParanoid; Q8BHH9; -.
DR OMA; DEFRGHC; -.
DR OrthoDB; 1596832at2759; -.
DR PhylomeDB; Q8BHH9; -.
DR TreeFam; TF324841; -.
DR BioGRID-ORCS; 104885; 6 hits in 72 CRISPR screens.
DR ChiTaRS; Tmem179; mouse.
DR PRO; PR:Q8BHH9; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BHH9; protein.
DR Bgee; ENSMUSG00000054013; Expressed in dorsomedial nucleus of hypothalamus and 111 other tissues.
DR ExpressionAtlas; Q8BHH9; baseline and differential.
DR Genevisible; Q8BHH9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029673; TMEM179.
DR PANTHER; PTHR31872; PTHR31872; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..233
FT /note="Transmembrane protein 179"
FT /id="PRO_0000254553"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 185
FT /note="L -> P (in Ref. 1; BAC41142)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="Q -> E (in Ref. 1; BAC41142)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 233 AA; 26463 MW; 1CA9BBB71AD38C7D CRC64;
MALNNFLFAQ CVCYFLAFLF SFVVVVPLSE NGHDFRGRCL LFTEGMWLSA NLTMQGRERF
TVQEWGPPAA CRFSLLASLL SLLLAAAHAW RTLFFLCKGH EGSFFYAFLN LLVSAFVVFL
VFIASTIVSV GFTMWCDTIT EKGSTPHSCE EFQETDLELN VDNSAFYHQF AIAQFGLWAS
WLAWLAITTL AFLKVYHNYR QEDLLDSLVH EKELLLARPT SRTSFQGEKS AVI
