T179B_HUMAN
ID T179B_HUMAN Reviewed; 219 AA.
AC Q7Z7N9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Transmembrane protein 179B;
GN Name=TMEM179B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206 AND SER-214, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q7Z7N9; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-11724423, EBI-10827839;
CC Q7Z7N9; Q9BQE5: APOL2; NbExp=3; IntAct=EBI-11724423, EBI-4290634;
CC Q7Z7N9; Q92843: BCL2L2; NbExp=3; IntAct=EBI-11724423, EBI-707714;
CC Q7Z7N9; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-11724423, EBI-8648738;
CC Q7Z7N9; Q86Z23: C1QL4; NbExp=3; IntAct=EBI-11724423, EBI-12062109;
CC Q7Z7N9; O14523: C2CD2L; NbExp=3; IntAct=EBI-11724423, EBI-12822627;
CC Q7Z7N9; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-11724423, EBI-9083477;
CC Q7Z7N9; P16619: CCL3L3; NbExp=3; IntAct=EBI-11724423, EBI-12934095;
CC Q7Z7N9; P13236: CCL4; NbExp=3; IntAct=EBI-11724423, EBI-2873970;
CC Q7Z7N9; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-11724423, EBI-10271156;
CC Q7Z7N9; P34810: CD68; NbExp=3; IntAct=EBI-11724423, EBI-2826276;
CC Q7Z7N9; P51798: CLCN7; NbExp=3; IntAct=EBI-11724423, EBI-4402346;
CC Q7Z7N9; O95832: CLDN1; NbExp=3; IntAct=EBI-11724423, EBI-723889;
CC Q7Z7N9; P56747: CLDN6; NbExp=3; IntAct=EBI-11724423, EBI-12955011;
CC Q7Z7N9; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-11724423, EBI-12019274;
CC Q7Z7N9; P49447: CYB561; NbExp=3; IntAct=EBI-11724423, EBI-8646596;
CC Q7Z7N9; Q96Q80: DERL3; NbExp=3; IntAct=EBI-11724423, EBI-12831318;
CC Q7Z7N9; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-11724423, EBI-781551;
CC Q7Z7N9; Q96GL9: FAM163A; NbExp=3; IntAct=EBI-11724423, EBI-11793142;
CC Q7Z7N9; Q969F0: FATE1; NbExp=3; IntAct=EBI-11724423, EBI-743099;
CC Q7Z7N9; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-11724423, EBI-12175685;
CC Q7Z7N9; Q8N3T1: GALNT15; NbExp=3; IntAct=EBI-11724423, EBI-3925203;
CC Q7Z7N9; Q9NS71: GKN1; NbExp=3; IntAct=EBI-11724423, EBI-3933251;
CC Q7Z7N9; Q86YW7: GPHB5; NbExp=3; IntAct=EBI-11724423, EBI-11659720;
CC Q7Z7N9; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-11724423, EBI-11955647;
CC Q7Z7N9; Q02747: GUCA2A; NbExp=3; IntAct=EBI-11724423, EBI-12244272;
CC Q7Z7N9; P24593: IGFBP5; NbExp=3; IntAct=EBI-11724423, EBI-720480;
CC Q7Z7N9; O43736: ITM2A; NbExp=3; IntAct=EBI-11724423, EBI-2431769;
CC Q7Z7N9; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11724423, EBI-10176379;
CC Q7Z7N9; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-11724423, EBI-12007212;
CC Q7Z7N9; Q7Z4F1: LRP10; NbExp=3; IntAct=EBI-11724423, EBI-2830349;
CC Q7Z7N9; Q8N1E2: LYG1; NbExp=3; IntAct=EBI-11724423, EBI-13309213;
CC Q7Z7N9; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-11724423, EBI-10317612;
CC Q7Z7N9; Q6N075: MFSD5; NbExp=3; IntAct=EBI-11724423, EBI-3920969;
CC Q7Z7N9; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-11724423, EBI-2858252;
CC Q7Z7N9; P26678: PLN; NbExp=3; IntAct=EBI-11724423, EBI-692836;
CC Q7Z7N9; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-11724423, EBI-749270;
CC Q7Z7N9; P43005: SLC1A1; NbExp=3; IntAct=EBI-11724423, EBI-745376;
CC Q7Z7N9; Q9NWF4: SLC52A1; NbExp=3; IntAct=EBI-11724423, EBI-12904614;
CC Q7Z7N9; Q9UNK0: STX8; NbExp=3; IntAct=EBI-11724423, EBI-727240;
CC Q7Z7N9; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-11724423, EBI-6448756;
CC Q7Z7N9; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-11724423, EBI-2800360;
CC Q7Z7N9; Q5W0B7: TMEM236; NbExp=3; IntAct=EBI-11724423, EBI-13378608;
CC Q7Z7N9; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-11724423, EBI-10982110;
CC Q7Z7N9; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-11724423, EBI-10315004;
CC Q7Z7N9; Q9BQJ4: TMEM47; NbExp=3; IntAct=EBI-11724423, EBI-13370320;
CC Q7Z7N9; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-11724423, EBI-10243654;
CC Q7Z7N9; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-11724423, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM179 family. {ECO:0000305}.
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DR EMBL; CH471076; EAW74098.1; -; Genomic_DNA.
DR EMBL; BC051355; AAH51355.1; -; mRNA.
DR CCDS; CCDS8036.1; -.
DR RefSeq; NP_955369.1; NM_199337.2.
DR AlphaFoldDB; Q7Z7N9; -.
DR BioGRID; 131898; 105.
DR IntAct; Q7Z7N9; 60.
DR MINT; Q7Z7N9; -.
DR STRING; 9606.ENSP00000333697; -.
DR TCDB; 9.B.201.1.2; the 4 tms tmem179 (tmem179) family.
DR GlyGen; Q7Z7N9; 2 sites.
DR iPTMnet; Q7Z7N9; -.
DR PhosphoSitePlus; Q7Z7N9; -.
DR SwissPalm; Q7Z7N9; -.
DR BioMuta; TMEM179B; -.
DR DMDM; 74738902; -.
DR EPD; Q7Z7N9; -.
DR jPOST; Q7Z7N9; -.
DR MassIVE; Q7Z7N9; -.
DR MaxQB; Q7Z7N9; -.
DR PaxDb; Q7Z7N9; -.
DR PeptideAtlas; Q7Z7N9; -.
DR PRIDE; Q7Z7N9; -.
DR ProteomicsDB; 69572; -.
DR Antibodypedia; 14985; 27 antibodies from 9 providers.
DR DNASU; 374395; -.
DR Ensembl; ENST00000333449.9; ENSP00000333697.3; ENSG00000185475.11.
DR GeneID; 374395; -.
DR KEGG; hsa:374395; -.
DR MANE-Select; ENST00000333449.9; ENSP00000333697.3; NM_199337.3; NP_955369.1.
DR UCSC; uc001nvd.5; human.
DR CTD; 374395; -.
DR GeneCards; TMEM179B; -.
DR HGNC; HGNC:33744; TMEM179B.
DR HPA; ENSG00000185475; Low tissue specificity.
DR neXtProt; NX_Q7Z7N9; -.
DR OpenTargets; ENSG00000185475; -.
DR PharmGKB; PA162405996; -.
DR VEuPathDB; HostDB:ENSG00000185475; -.
DR eggNOG; ENOG502S28I; Eukaryota.
DR GeneTree; ENSGT00510000048151; -.
DR HOGENOM; CLU_109636_0_0_1; -.
DR InParanoid; Q7Z7N9; -.
DR OMA; YWVYTFC; -.
DR OrthoDB; 1242297at2759; -.
DR PhylomeDB; Q7Z7N9; -.
DR TreeFam; TF324841; -.
DR PathwayCommons; Q7Z7N9; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; Q7Z7N9; -.
DR BioGRID-ORCS; 374395; 21 hits in 1083 CRISPR screens.
DR ChiTaRS; TMEM179B; human.
DR GenomeRNAi; 374395; -.
DR Pharos; Q7Z7N9; Tdark.
DR PRO; PR:Q7Z7N9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q7Z7N9; protein.
DR Bgee; ENSG00000185475; Expressed in mucosa of transverse colon and 94 other tissues.
DR ExpressionAtlas; Q7Z7N9; baseline and differential.
DR Genevisible; Q7Z7N9; HS.
DR GO; GO:0035577; C:azurophil granule membrane; TAS:Reactome.
DR GO; GO:0101003; C:ficolin-1-rich granule membrane; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0030667; C:secretory granule membrane; TAS:Reactome.
DR InterPro; IPR029776; TMEM179B.
DR PANTHER; PTHR31056; PTHR31056; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..219
FT /note="Transmembrane protein 179B"
FT /id="PRO_0000328987"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 198..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 214
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
SQ SEQUENCE 219 AA; 23550 MW; 0D9EE5D760A0A10E CRC64;
MALSWLQRVE LALFAAAFLC GAVAAAAMTR TQGSFSGRCP LYGVATLNGS SLALSRPSAP
SLCYFVAGAS GLLALYCLLL LLFWIYSSCI EDSHRGAIGL RIALAISAIA VFLVLVSACI
LRFGTRSLCN SIISLNTTIS CSEAQKIPWT PPGTALQFYS NLHNAETSSW VNLVLWCVVL
VLQVVQWKSE ATPYRPLERG DPEWSSETDA LVGSRLSHS
