T179B_MOUSE
ID T179B_MOUSE Reviewed; 219 AA.
AC Q9CY24; Q9D8L7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Transmembrane protein 179B;
GN Name=Tmem179b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM179 family. {ECO:0000305}.
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DR EMBL; AK007906; BAB25340.1; -; mRNA.
DR EMBL; AK010996; BAB27315.1; -; mRNA.
DR EMBL; BC116961; AAI16962.1; -; mRNA.
DR EMBL; BC116963; AAI16964.1; -; mRNA.
DR CCDS; CCDS29545.1; -.
DR RefSeq; NP_080601.2; NM_026325.3.
DR AlphaFoldDB; Q9CY24; -.
DR IntAct; Q9CY24; 1.
DR iPTMnet; Q9CY24; -.
DR PhosphoSitePlus; Q9CY24; -.
DR EPD; Q9CY24; -.
DR jPOST; Q9CY24; -.
DR MaxQB; Q9CY24; -.
DR PaxDb; Q9CY24; -.
DR PeptideAtlas; Q9CY24; -.
DR PRIDE; Q9CY24; -.
DR ProteomicsDB; 263224; -.
DR Antibodypedia; 14985; 27 antibodies from 9 providers.
DR DNASU; 67706; -.
DR Ensembl; ENSMUST00000010249; ENSMUSP00000010249; ENSMUSG00000118346.
DR GeneID; 67706; -.
DR KEGG; mmu:67706; -.
DR UCSC; uc008gmt.2; mouse.
DR CTD; 374395; -.
DR MGI; MGI:1914956; Tmem179b.
DR VEuPathDB; HostDB:ENSMUSG00000118346; -.
DR GeneTree; ENSGT00510000048151; -.
DR HOGENOM; CLU_109636_0_0_1; -.
DR InParanoid; Q9CY24; -.
DR OMA; YWVYTFC; -.
DR OrthoDB; 1242297at2759; -.
DR PhylomeDB; Q9CY24; -.
DR TreeFam; TF324841; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 67706; 0 hits in 25 CRISPR screens.
DR ChiTaRS; Tmem179b; mouse.
DR PRO; PR:Q9CY24; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9CY24; protein.
DR Bgee; ENSMUSG00000118346; Expressed in bone marrow and 64 other tissues.
DR ExpressionAtlas; Q9CY24; baseline and differential.
DR Genevisible; Q9CY24; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR InterPro; IPR029776; TMEM179B.
DR PANTHER; PTHR31056; PTHR31056; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..219
FT /note="Transmembrane protein 179B"
FT /id="PRO_0000328988"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z7N9"
FT CONFLICT 140
FT /note="S -> N (in Ref. 1; BAB25340)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 23528 MW; F980985A36DBF3D1 CRC64;
MALPWLQRVE LLLFTAAFLC GALAAATLTR TQGSFGGNCP LYGVAALNGS SLALLGPSAP
SLCYFVAGAS GILALYCLLL LFFWVYSSCI EDSHRGSIGL RIALAISATA IFLILVSACI
LRFGTNSFCN SIISLNLTIS CSEAQKTSWT PSGTAVQFYS NLHTAETSSW VNLILWCLAL
LLQAMQCKFK ATSYQPQERG DQEWSSETDA LVGHHQSHS
