T183A_HUMAN
ID T183A_HUMAN Reviewed; 376 AA.
AC Q8IXX5; A8K5W1; Q6NW15; Q96E06;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transmembrane protein 183A;
GN Name=TMEM183A; Synonyms=C1orf37;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Urinary bladder;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP MET-10 AND THR-80.
RC TISSUE=Brain, and Duodenum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IXX5; O14879: IFIT3; NbExp=7; IntAct=EBI-2841953, EBI-745127;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IXX5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IXX5-2; Sequence=VSP_015084;
CC -!- SIMILARITY: Belongs to the TMEM183 family. {ECO:0000305}.
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DR EMBL; AK291426; BAF84115.1; -; mRNA.
DR EMBL; AK312985; BAG35822.1; -; mRNA.
DR EMBL; CH471067; EAW91457.1; -; Genomic_DNA.
DR EMBL; BC013073; AAH13073.1; -; mRNA.
DR EMBL; BC038952; AAH38952.1; -; mRNA.
DR EMBL; BC067775; AAH67775.1; -; mRNA.
DR EMBL; BC150647; AAI50648.1; -; mRNA.
DR CCDS; CCDS1432.1; -. [Q8IXX5-1]
DR RefSeq; NP_612400.3; NM_138391.4. [Q8IXX5-1]
DR AlphaFoldDB; Q8IXX5; -.
DR BioGRID; 124969; 30.
DR IntAct; Q8IXX5; 5.
DR MINT; Q8IXX5; -.
DR STRING; 9606.ENSP00000356211; -.
DR iPTMnet; Q8IXX5; -.
DR PhosphoSitePlus; Q8IXX5; -.
DR BioMuta; TMEM183A; -.
DR DMDM; 126302527; -.
DR EPD; Q8IXX5; -.
DR jPOST; Q8IXX5; -.
DR MassIVE; Q8IXX5; -.
DR MaxQB; Q8IXX5; -.
DR PaxDb; Q8IXX5; -.
DR PeptideAtlas; Q8IXX5; -.
DR PRIDE; Q8IXX5; -.
DR ProteomicsDB; 71074; -. [Q8IXX5-1]
DR ProteomicsDB; 71075; -. [Q8IXX5-2]
DR Antibodypedia; 77926; 4 antibodies from 4 providers.
DR DNASU; 92703; -.
DR Ensembl; ENST00000367242.4; ENSP00000356211.3; ENSG00000163444.12. [Q8IXX5-1]
DR GeneID; 92703; -.
DR KEGG; hsa:92703; -.
DR MANE-Select; ENST00000367242.4; ENSP00000356211.3; NM_138391.6; NP_612400.3.
DR UCSC; uc001gyu.2; human. [Q8IXX5-1]
DR CTD; 92703; -.
DR DisGeNET; 92703; -.
DR GeneCards; TMEM183A; -.
DR HGNC; HGNC:20173; TMEM183A.
DR HPA; ENSG00000163444; Low tissue specificity.
DR neXtProt; NX_Q8IXX5; -.
DR OpenTargets; ENSG00000163444; -.
DR PharmGKB; PA162406090; -.
DR VEuPathDB; HostDB:ENSG00000163444; -.
DR eggNOG; ENOG502QS4U; Eukaryota.
DR GeneTree; ENSGT00390000009310; -.
DR HOGENOM; CLU_061444_1_0_1; -.
DR InParanoid; Q8IXX5; -.
DR OMA; DCCLLQI; -.
DR OrthoDB; 1290599at2759; -.
DR PhylomeDB; Q8IXX5; -.
DR TreeFam; TF323300; -.
DR PathwayCommons; Q8IXX5; -.
DR SignaLink; Q8IXX5; -.
DR BioGRID-ORCS; 92703; 255 hits in 1038 CRISPR screens.
DR ChiTaRS; TMEM183A; human.
DR GenomeRNAi; 92703; -.
DR Pharos; Q8IXX5; Tdark.
DR PRO; PR:Q8IXX5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8IXX5; protein.
DR Bgee; ENSG00000163444; Expressed in rectum and 185 other tissues.
DR Genevisible; Q8IXX5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031647; P:regulation of protein stability; IBA:GO_Central.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR026509; TMEM183.
DR PANTHER; PTHR20988; PTHR20988; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..376
FT /note="Transmembrane protein 183A"
FT /id="PRO_0000089251"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 237..376
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_015084"
FT VARIANT 10
FT /note="R -> M (in dbSNP:rs11558253)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_023205"
FT VARIANT 80
FT /note="A -> T (in dbSNP:rs6678040)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_023206"
FT CONFLICT 59
FT /note="V -> I (in Ref. 3; AAH67775)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 376 AA; 42826 MW; 809A6780F128917B CRC64;
MARGPGPLGR PRPDTVAMPK RGKRLKFRAH DACSGRVTVA DYANSDPAVV RSGRVKKAVA
NAVQQEVKSL CGLEASQVPA EEALSGAGEP CDIIDSSDEM DAQEESIHER TVSRKKKSKR
HKEELDGAGG EEYPMDIWLL LASYIRPEDI VNFSLICKNA WTVTCTAAFW TRLYRRHYTL
DASLPLRLRP ESMEKLRCLR ACVIRSLYHM YEPFAARISK NPAIPESTPS TLKNSKCLLF
WCRKIVGNRQ EPMWEFNFKF KKQSPRLKSK CTGGLQPPVQ YEDVHTNPDQ DCCLLQVTTL
NFIFIPIVMG MIFTLFTINV STDMRHHRVR LVFQDSPVHG GRKLRSEQGV QVILDPVHSV
RLFDWWHPQY PFSLRA
