T183B_HUMAN
ID T183B_HUMAN Reviewed; 376 AA.
AC Q1AE95; Q1AE97;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Putative transmembrane protein 183BP {ECO:0000305};
DE AltName: Full=Transmembrane protein 183B pseudogene {ECO:0000312|HGNC:HGNC:33205};
GN Name=TMEM183BP {ECO:0000312|HGNC:HGNC:33205};
GN Synonyms=C1orf37-dup {ECO:0000303|PubMed:16644869},
GN TMEM183B {ECO:0000312|HGNC:HGNC:33205};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-193, AND TISSUE SPECIFICITY.
RX PubMed=16644869; DOI=10.1093/hmg/ddl109;
RA Yu H., Jiang H., Zhou Q., Yang J., Cun Y., Su B., Xiao C., Wang W.;
RT "Origination and evolution of a human-specific transmembrane protein gene,
RT c1orf37-dup.";
RL Hum. Mol. Genet. 15:1870-1875(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, lung, pancreas, thymus,
CC intestine and blood. Not detected in heart, placenta, liver, muscle,
CC kidney, spleen, prostate, testis, ovary and colon.
CC {ECO:0000269|PubMed:16644869}.
CC -!- MISCELLANEOUS: This gene was derived from TMEM183A through
CC retroposition after the divergence of human and chimpanzee.
CC {ECO:0000305|PubMed:16644869}.
CC -!- SIMILARITY: Belongs to the TMEM183 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; DQ186292; ABA18877.1; -; Genomic_DNA.
DR EMBL; DQ186293; ABA18878.1; -; Genomic_DNA.
DR EMBL; DQ186294; ABA18879.1; -; Genomic_DNA.
DR EMBL; DQ186295; ABA18880.1; -; Genomic_DNA.
DR EMBL; DQ186296; ABA18881.1; -; Genomic_DNA.
DR EMBL; DQ186297; ABA18882.1; -; Genomic_DNA.
DR EMBL; DQ186298; ABA18883.1; -; Genomic_DNA.
DR EMBL; DQ186299; ABA18884.1; -; Genomic_DNA.
DR EMBL; DQ186300; ABA18885.1; -; Genomic_DNA.
DR EMBL; DQ186301; ABA18886.1; -; Genomic_DNA.
DR EMBL; DQ186302; ABA18887.1; -; Genomic_DNA.
DR EMBL; DQ186303; ABA18888.1; -; Genomic_DNA.
DR EMBL; DQ186304; ABA18889.1; -; Genomic_DNA.
DR EMBL; DQ186305; ABA18890.1; -; Genomic_DNA.
DR EMBL; DQ186306; ABA18891.1; -; Genomic_DNA.
DR EMBL; DQ186307; ABA18892.1; -; Genomic_DNA.
DR EMBL; DQ186308; ABA18893.1; -; Genomic_DNA.
DR EMBL; DQ186309; ABA18894.1; -; Genomic_DNA.
DR EMBL; DQ186310; ABA18895.1; -; Genomic_DNA.
DR EMBL; DQ186311; ABA18896.1; -; Genomic_DNA.
DR EMBL; DQ186312; ABA18897.1; -; Genomic_DNA.
DR EMBL; DQ186313; ABA18898.1; -; Genomic_DNA.
DR EMBL; DQ186314; ABA18899.1; -; Genomic_DNA.
DR EMBL; DQ186315; ABA18900.1; -; Genomic_DNA.
DR EMBL; DQ186316; ABA18901.1; -; Genomic_DNA.
DR EMBL; DQ186317; ABA18902.1; -; Genomic_DNA.
DR EMBL; DQ186318; ABA18903.1; -; Genomic_DNA.
DR EMBL; DQ186319; ABA18904.1; -; Genomic_DNA.
DR EMBL; DQ186320; ABA18905.1; -; Genomic_DNA.
DR EMBL; DQ186321; ABA18906.1; -; Genomic_DNA.
DR EMBL; DQ186322; ABA18907.1; -; Genomic_DNA.
DR EMBL; DQ186323; ABA18908.1; -; Genomic_DNA.
DR EMBL; DQ186324; ABA18909.1; -; Genomic_DNA.
DR EMBL; DQ186325; ABA18910.1; -; Genomic_DNA.
DR EMBL; DQ186326; ABA18911.1; -; Genomic_DNA.
DR EMBL; DQ186327; ABA18912.1; -; Genomic_DNA.
DR EMBL; DQ186328; ABA18913.1; -; Genomic_DNA.
DR EMBL; DQ186329; ABA18914.1; -; Genomic_DNA.
DR EMBL; DQ186330; ABA18915.1; -; Genomic_DNA.
DR EMBL; DQ186331; ABA18916.1; -; Genomic_DNA.
DR EMBL; DQ186332; ABA18917.1; -; Genomic_DNA.
DR EMBL; DQ186333; ABA18918.1; -; Genomic_DNA.
DR EMBL; DQ186334; ABA18919.1; -; Genomic_DNA.
DR EMBL; DQ186335; ABA18920.1; -; Genomic_DNA.
DR EMBL; DQ186336; ABA18921.1; -; Genomic_DNA.
DR EMBL; DQ186337; ABA18922.1; -; Genomic_DNA.
DR EMBL; DQ186338; ABA18923.1; -; Genomic_DNA.
DR EMBL; DQ186339; ABA18924.1; -; Genomic_DNA.
DR EMBL; DQ186340; ABA18925.1; -; Genomic_DNA.
DR EMBL; DQ186341; ABA18926.1; -; Genomic_DNA.
DR EMBL; DQ186342; ABA18927.1; -; Genomic_DNA.
DR EMBL; DQ186343; ABA18928.1; -; Genomic_DNA.
DR EMBL; DQ186344; ABA18929.1; -; Genomic_DNA.
DR EMBL; DQ186345; ABA18930.1; -; Genomic_DNA.
DR EMBL; DQ186346; ABA18931.1; -; Genomic_DNA.
DR EMBL; DQ186347; ABA18932.1; -; Genomic_DNA.
DR EMBL; DQ186348; ABA18933.1; -; Genomic_DNA.
DR EMBL; DQ186349; ABA18934.1; -; Genomic_DNA.
DR EMBL; DQ186350; ABA18935.1; -; Genomic_DNA.
DR EMBL; DQ186351; ABA18936.1; -; Genomic_DNA.
DR EMBL; DQ186352; ABA18937.1; -; Genomic_DNA.
DR EMBL; DQ186353; ABA18938.1; -; Genomic_DNA.
DR EMBL; DQ186354; ABA18939.1; -; Genomic_DNA.
DR EMBL; DQ186355; ABA18940.1; -; Genomic_DNA.
DR EMBL; DQ186356; ABA18941.1; -; Genomic_DNA.
DR EMBL; DQ186357; ABA18942.1; -; Genomic_DNA.
DR EMBL; DQ186358; ABA18943.1; -; Genomic_DNA.
DR EMBL; DQ186359; ABA18944.1; -; Genomic_DNA.
DR EMBL; DQ186360; ABA18945.1; -; Genomic_DNA.
DR EMBL; DQ186361; ABA18946.1; -; Genomic_DNA.
DR EMBL; DQ186362; ABA18947.1; -; Genomic_DNA.
DR EMBL; DQ186363; ABA18948.1; -; Genomic_DNA.
DR EMBL; DQ186364; ABA18949.1; -; Genomic_DNA.
DR EMBL; DQ186365; ABA18950.1; -; Genomic_DNA.
DR EMBL; DQ186366; ABA18951.1; -; Genomic_DNA.
DR EMBL; DQ186367; ABA18952.1; -; Genomic_DNA.
DR EMBL; DQ186368; ABA18953.1; -; Genomic_DNA.
DR EMBL; DQ186369; ABA18954.1; -; Genomic_DNA.
DR EMBL; DQ186370; ABA18955.1; -; Genomic_DNA.
DR EMBL; DQ186371; ABA18956.1; -; Genomic_DNA.
DR EMBL; DQ186372; ABA18957.1; -; Genomic_DNA.
DR EMBL; DQ186373; ABA18958.1; -; Genomic_DNA.
DR EMBL; DQ186374; ABA18959.1; -; Genomic_DNA.
DR EMBL; DQ186375; ABA18960.1; -; Genomic_DNA.
DR EMBL; DQ186376; ABA18961.1; -; Genomic_DNA.
DR EMBL; DQ186377; ABA18962.1; -; Genomic_DNA.
DR EMBL; DQ186378; ABA18963.1; -; Genomic_DNA.
DR EMBL; DQ186379; ABA18964.1; -; Genomic_DNA.
DR EMBL; DQ186380; ABA18965.1; -; Genomic_DNA.
DR EMBL; DQ186381; ABA18966.1; -; Genomic_DNA.
DR EMBL; DQ186382; ABA18967.1; -; Genomic_DNA.
DR EMBL; DQ186383; ABA18968.1; -; Genomic_DNA.
DR EMBL; DQ186384; ABA18969.1; -; Genomic_DNA.
DR EMBL; DQ186385; ABA18970.1; -; Genomic_DNA.
DR EMBL; DQ186386; ABA18971.1; -; Genomic_DNA.
DR EMBL; DQ186387; ABA18972.1; -; Genomic_DNA.
DR EMBL; DQ186388; ABA18973.1; -; Genomic_DNA.
DR EMBL; DQ186389; ABA18974.1; -; Genomic_DNA.
DR EMBL; DQ186390; ABA18975.1; -; Genomic_DNA.
DR EMBL; DQ186391; ABA18976.1; -; Genomic_DNA.
DR EMBL; DQ186392; ABA18977.1; -; Genomic_DNA.
DR EMBL; DQ186393; ABA18978.1; -; Genomic_DNA.
DR EMBL; DQ186394; ABA18979.1; -; Genomic_DNA.
DR EMBL; DQ186395; ABA18980.1; -; Genomic_DNA.
DR EMBL; DQ186396; ABA18981.1; -; Genomic_DNA.
DR EMBL; DQ186397; ABA18982.1; -; Genomic_DNA.
DR EMBL; DQ186398; ABA18983.1; -; Genomic_DNA.
DR EMBL; DQ186399; ABA18984.1; -; Genomic_DNA.
DR EMBL; DQ186400; ABA18985.1; -; Genomic_DNA.
DR EMBL; DQ186401; ABA18986.1; -; Genomic_DNA.
DR EMBL; DQ186402; ABA18987.1; -; Genomic_DNA.
DR EMBL; DQ186403; ABA18988.1; -; Genomic_DNA.
DR EMBL; DQ186404; ABA18989.1; -; Genomic_DNA.
DR EMBL; DQ186405; ABA18990.1; -; Genomic_DNA.
DR EMBL; DQ186406; ABA18991.1; -; Genomic_DNA.
DR EMBL; DQ186407; ABA18992.1; -; Genomic_DNA.
DR EMBL; DQ186408; ABA18993.1; -; Genomic_DNA.
DR EMBL; DQ186409; ABA18994.1; -; Genomic_DNA.
DR EMBL; DQ186410; ABA18995.1; -; Genomic_DNA.
DR EMBL; DQ186411; ABA18996.1; -; Genomic_DNA.
DR EMBL; DQ186412; ABA18997.1; -; Genomic_DNA.
DR EMBL; DQ186413; ABA18998.1; -; Genomic_DNA.
DR RefSeq; NP_001073277.1; NM_001079809.1.
DR AlphaFoldDB; Q1AE95; -.
DR BioGRID; 575963; 1.
DR iPTMnet; Q1AE95; -.
DR PhosphoSitePlus; Q1AE95; -.
DR BioMuta; HGNC:33205; -.
DR DMDM; 121940655; -.
DR jPOST; Q1AE95; -.
DR MassIVE; Q1AE95; -.
DR MaxQB; Q1AE95; -.
DR PeptideAtlas; Q1AE95; -.
DR PRIDE; Q1AE95; -.
DR DNASU; 653659; -.
DR GeneID; 653659; -.
DR CTD; 653659; -.
DR GeneCards; TMEM183BP; -.
DR HGNC; HGNC:33205; TMEM183BP.
DR MIM; 611365; gene.
DR neXtProt; NX_Q1AE95; -.
DR InParanoid; Q1AE95; -.
DR OrthoDB; 1290599at2759; -.
DR PhylomeDB; Q1AE95; -.
DR PathwayCommons; Q1AE95; -.
DR BioGRID-ORCS; 653659; 10 hits in 146 CRISPR screens.
DR ChiTaRS; TMEM183B; human.
DR GenomeRNAi; 653659; -.
DR Pharos; Q1AE95; Tdark.
DR PRO; PR:Q1AE95; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q1AE95; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031647; P:regulation of protein stability; IBA:GO_Central.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR026509; TMEM183.
DR PANTHER; PTHR20988; PTHR20988; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 5: Uncertain;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..376
FT /note="Putative transmembrane protein 183BP"
FT /id="PRO_0000278796"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 193
FT /note="M -> V (in dbSNP:rs7630407)"
FT /evidence="ECO:0000269|PubMed:16644869"
FT /id="VAR_030867"
SQ SEQUENCE 376 AA; 42940 MW; 1435A8F834431B33 CRC64;
MARGPGPLGR PRPDTVAMPK RGKRLKFRAH DACSGRVTVA DYADSDLAVV RSGRVKKAVA
NAVRQEVKSL CGLEASQVPA EEALSGAGEP YDIIDSSDEM DAQEENIHER TVSRKKKSKR
HKEELDGAGG EEYPMDIWLL LASYIRPEDI VNFSLICKNA WTVTCTAAFW TRLYRRHYTL
DASLPLRLRP ESMEKLHCLR ACVIRSLYHM YEPFAARISK NPAIPESTPS TLKNSKCLLF
WCRKIVGNRQ EPMWEFNFKF KKQSPRLKSK CTGGLQPPVQ YEDVHTNPDQ DCCLLQVTTL
NFIFIPIVMG MIFTLFTINV STDMRHHRVR LVFQDSPVHG GRKLRSEQGV QVILDPVHSV
RLFDWWHPQY PFSLRA
