ID   T1841_DICDI             Reviewed;         493 AA.
AC   Q54PI4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Transmembrane protein 184 homolog DDB_G0284525;
GN   Name=tmem184A; ORFNames=DDB_G0284525;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
CC   -!- CAUTION: Despite its name, this protein may not be the one-to-one
CC       ortholog of TMEM184A. {ECO:0000305}.
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DR   EMBL; AAFI02000066; EAL65189.1; -; Genomic_DNA.
DR   RefSeq; XP_638548.1; XM_633456.1.
DR   AlphaFoldDB; Q54PI4; -.
DR   STRING; 44689.DDB0304965; -.
DR   PaxDb; Q54PI4; -.
DR   PRIDE; Q54PI4; -.
DR   EnsemblProtists; EAL65189; EAL65189; DDB_G0284525.
DR   GeneID; 8624641; -.
DR   KEGG; ddi:DDB_G0284525; -.
DR   dictyBase; DDB_G0284525; tmem184A.
DR   eggNOG; KOG2641; Eukaryota.
DR   HOGENOM; CLU_549122_0_0_1; -.
DR   InParanoid; Q54PI4; -.
DR   OMA; CRMGMLQ; -.
DR   PhylomeDB; Q54PI4; -.
DR   PRO; PR:Q54PI4; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005178; Ostalpha/TMEM184C.
DR   PANTHER; PTHR23423; PTHR23423; 1.
DR   Pfam; PF03619; Solute_trans_a; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..493
FT                   /note="Transmembrane protein 184 homolog DDB_G0284525"
FT                   /id="PRO_0000379800"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        415
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        416
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   493 AA;  55935 MW;  7A3EC3C5F9196FB6 CRC64;
     MTQESSSSNH YVDESSFDNN NNNNNNGGEG SSNEILIRIP FLHDSVPALY AMFALASLFV
     LLATILSAHL IYKHLKYYTQ PDHQRYIVRI VFMIPIYAIY SLLSLLLHNY QVYFALLRDC
     YEAYVLYMFF ALCVSYGGGD KNLVTHFTSH PVMRLPMPLF FKFKPNEAFL QVCRMGMLQY
     VLVRPAVTLA SAIFEIFGLY DEGSYAINRF YFYNAFIINV SVTVALYIVV LFYQAAAEEL
     APYKPLLKFT SIKIVVFFCF WQSIAISGMT NFGWIPTLDG WNSGEVSTGL QNFLICFEMF
     GVAILHQYAF PYELYRVRAF SAAPLIHRVE MGTVFKSVIN SVSQKDMVKE TVKSFKGTKI
     TDGKTGLYSG LKDEVFNEFD IEEIEMGDFT SANDNNNFDD FDFSENNINS NNKDNNSSIY
     NDGASKKNHI GSAILAGGGG GGKKDNDLIT DDDFFSLMNN DYANIDFSNF DQDALEEMNF
     DDDDDDMAFT ARR