T1842_DICDI
ID T1842_DICDI Reviewed; 507 AA.
AC Q75JN3; Q551Y2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Transmembrane protein 184 homolog DDB_G0276041;
GN Name=tmem184B; ORFNames=DDB_G0276041;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
CC -!- CAUTION: Despite its name, this protein may not be the one-to-one
CC ortholog of TMEM184B. {ECO:0000305}.
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DR EMBL; AAFI02000014; EAL69320.1; -; Genomic_DNA.
DR RefSeq; XP_643346.1; XM_638254.1.
DR AlphaFoldDB; Q75JN3; -.
DR STRING; 44689.DDB0304966; -.
DR PaxDb; Q75JN3; -.
DR EnsemblProtists; EAL69320; EAL69320; DDB_G0276041.
DR GeneID; 8620396; -.
DR KEGG; ddi:DDB_G0276041; -.
DR dictyBase; DDB_G0276041; tmem184B.
DR eggNOG; KOG2641; Eukaryota.
DR HOGENOM; CLU_537973_0_0_1; -.
DR InParanoid; Q75JN3; -.
DR OMA; VMFYEVF; -.
DR PhylomeDB; Q75JN3; -.
DR PRO; PR:Q75JN3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..507
FT /note="Transmembrane protein 184 homolog DDB_G0276041"
FT /id="PRO_0000331552"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 448..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 360
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 375
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 470
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 473
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 477
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 498
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 507 AA; 58061 MW; D49CD8FC591C0553 CRC64;
MTTIVEEEPL FYIVMLSIGS FFALGSIIIA VILILQHFIH YNKPNHQKYI VRIIMIAPIY
AIHSLLSLFF KRQFWALFFD ISRDCYEAYV LYCFFKLLIC FLGGEEALKE LLSKKDTQPL
TWPLGYFFSF TPKKSFYRLS LGLVLQYAII KPTLAIVAAI LYYNNKYLEG DFSISQGYLW
ITVINNISVL IALYFLVMFY EVFQNELSPH SPILKFLVIK SVVFFLFWQT VVITVLIWFD
ALPKSDVYSS EHIGYFINDF LVCIEMFITS IAMGICFSYS DYVIDKSTHD EILGNGKRSS
SRGIGSRSGR NIKISSKIKN IKNNFNRYRH NIGDGLSDVN NPKDIILDTI MVAKLNKNNN
NTNNNEINNG IIDNNNSNNI ENNGKSRNNI ENNIDSQDYF NFIDLNTNDK EKQSKSKYFK
IKMPDSDQSS LINLDQCESP SILYGSLNGA SNNNNNNNNN NNNINNNNNN NSNNSNNNSN
SQFESIDINS NSVNSNKNQS DAILFTF
