T184A_BOVIN
ID T184A_BOVIN Reviewed; 414 AA.
AC Q1RMW2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Transmembrane protein 184A;
GN Name=TMEM184A;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=26769966; DOI=10.1074/jbc.m115.681122;
RA Pugh R.J., Slee J.B., Farwell S.L., Li Y., Barthol T., Patton W.A.,
RA Lowe-Krentz L.J.;
RT "Transmembrane protein 184A is a receptor required for vascular smooth
RT muscle cell responses to heparin.";
RL J. Biol. Chem. 291:5326-5341(2016).
CC -!- FUNCTION: Acts as a heparin receptor in vascular cells (By similarity).
CC May be involved in vesicle transport in exocrine cells and Sertoli
CC cells (By similarity). {ECO:0000250|UniProtKB:Q3UFJ6,
CC ECO:0000250|UniProtKB:Q4QQS1}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26769966};
CC Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear
CC region {ECO:0000269|PubMed:26769966}. Cytoplasmic vesicle membrane
CC {ECO:0000269|PubMed:26769966}; Multi-pass membrane protein
CC {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q3UFJ6};
CC Multi-pass membrane protein {ECO:0000255}. Endosome
CC {ECO:0000250|UniProtKB:Q3UFJ6}. Cytoplasmic vesicle, secretory vesicle
CC membrane {ECO:0000250|UniProtKB:Q3UFJ6}. Note=Colocalizes with CAV1.
CC {ECO:0000269|PubMed:26769966}.
CC -!- TISSUE SPECIFICITY: Expressed in vascular cells (at protein level).
CC {ECO:0000269|PubMed:26769966}.
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
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DR EMBL; BC114674; AAI14675.1; -; mRNA.
DR RefSeq; NP_001039737.1; NM_001046272.1.
DR RefSeq; XP_010817863.1; XM_010819561.2.
DR AlphaFoldDB; Q1RMW2; -.
DR STRING; 9913.ENSBTAP00000006135; -.
DR PaxDb; Q1RMW2; -.
DR Ensembl; ENSBTAT00000006135; ENSBTAP00000006135; ENSBTAG00000004676.
DR Ensembl; ENSBTAT00000070260; ENSBTAP00000070248; ENSBTAG00000004676.
DR GeneID; 524484; -.
DR KEGG; bta:524484; -.
DR CTD; 202915; -.
DR VEuPathDB; HostDB:ENSBTAG00000004676; -.
DR VGNC; VGNC:36009; TMEM184A.
DR eggNOG; KOG2641; Eukaryota.
DR GeneTree; ENSGT00940000153861; -.
DR HOGENOM; CLU_012923_3_0_1; -.
DR InParanoid; Q1RMW2; -.
DR OMA; CEQRYII; -.
DR OrthoDB; 462913at2759; -.
DR TreeFam; TF314160; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000004676; Expressed in surface of tongue and 85 other tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IDA:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0030667; C:secretory granule membrane; ISS:UniProtKB.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IDA:UniProtKB.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Cytoplasmic vesicle; Endosome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..414
FT /note="Transmembrane protein 184A"
FT /id="PRO_0000300467"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 45604 MW; 40444949ED7A1664 CRC64;
MTDTPGLLGT PLAWTPPARP AGPQMERAGN GSQGPGPLFL TSPLARGVSG VFVWAALVLT
GHQIYLHLRS YTVPHEQRYI IRLLFIVPVY AFDSWLSLLL LGGHQHYIYF DSVRDCYEAF
VIYSFLSLCF QYLGGESAIM AEIRGKPVRT SCFHGTCCLR GMTYSIGFLR FCKQATLQFC
IVKPIMALVT IVLQAFGKYH DGDFNVRSGY LYITLVYNAS VSLALYALFL FYSATRELLQ
PFEPVLKFLT IKAVIFLSFW QGLLLAILER CGVIPEVQVI DGSTVGAGTV AAGYQNFIIC
IEMLFASIAL RYAFTCQVYS EKTESSPAPS APMQSISSGL KETMSPQDIV QDAIHNFSPA
YQKYTQQATQ EAPRPGQGSV PSPRTPTHSP DGGPGGGRKG RNVEKRMLIP AEEL
