T184A_HUMAN
ID T184A_HUMAN Reviewed; 413 AA.
AC Q6ZMB5; Q8TBQ6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Transmembrane protein 184A;
GN Name=TMEM184A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Signet-ring cell carcinoma, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-18 AND GLY-390.
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND TISSUE SPECIFICITY.
RX PubMed=26769966; DOI=10.1074/jbc.m115.681122;
RA Pugh R.J., Slee J.B., Farwell S.L., Li Y., Barthol T., Patton W.A.,
RA Lowe-Krentz L.J.;
RT "Transmembrane protein 184A is a receptor required for vascular smooth
RT muscle cell responses to heparin.";
RL J. Biol. Chem. 291:5326-5341(2016).
CC -!- FUNCTION: Acts as a heparin receptor in vascular cells (By similarity).
CC May be involved in vesicle transport in exocrine cells and Sertoli
CC cells (By similarity). {ECO:0000250|UniProtKB:Q3UFJ6,
CC ECO:0000250|UniProtKB:Q4QQS1}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q4QQS1};
CC Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear
CC region {ECO:0000250|UniProtKB:Q4QQS1}. Cytoplasmic vesicle membrane
CC {ECO:0000250|UniProtKB:Q1RMW2}; Multi-pass membrane protein
CC {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q3UFJ6};
CC Multi-pass membrane protein {ECO:0000255}. Endosome
CC {ECO:0000250|UniProtKB:Q3UFJ6}. Cytoplasmic vesicle, secretory vesicle
CC membrane {ECO:0000250|UniProtKB:Q3UFJ6}.
CC -!- TISSUE SPECIFICITY: Expressed in vascular cells (at protein level).
CC {ECO:0000269|PubMed:26769966}.
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86522.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites.; Evidence={ECO:0000305};
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DR EMBL; AK126312; BAC86522.2; ALT_SEQ; mRNA.
DR EMBL; AK172850; BAD18814.1; -; mRNA.
DR EMBL; CH471144; EAW87210.1; -; Genomic_DNA.
DR EMBL; BC026694; AAH26694.1; -; mRNA.
DR CCDS; CCDS43537.1; -.
DR RefSeq; NP_001091089.1; NM_001097620.1.
DR AlphaFoldDB; Q6ZMB5; -.
DR BioGRID; 128441; 116.
DR IntAct; Q6ZMB5; 27.
DR STRING; 9606.ENSP00000297477; -.
DR TCDB; 2.A.82.1.9; the organic solute transporter (ost) family.
DR iPTMnet; Q6ZMB5; -.
DR PhosphoSitePlus; Q6ZMB5; -.
DR BioMuta; TMEM184A; -.
DR DMDM; 74710509; -.
DR jPOST; Q6ZMB5; -.
DR MassIVE; Q6ZMB5; -.
DR MaxQB; Q6ZMB5; -.
DR PaxDb; Q6ZMB5; -.
DR PeptideAtlas; Q6ZMB5; -.
DR PRIDE; Q6ZMB5; -.
DR ProteomicsDB; 67863; -.
DR Antibodypedia; 10987; 83 antibodies from 24 providers.
DR DNASU; 202915; -.
DR Ensembl; ENST00000297477.10; ENSP00000297477.4; ENSG00000164855.16.
DR GeneID; 202915; -.
DR KEGG; hsa:202915; -.
DR MANE-Select; ENST00000297477.10; ENSP00000297477.4; NM_001097620.2; NP_001091089.1.
DR UCSC; uc003skv.4; human.
DR CTD; 202915; -.
DR DisGeNET; 202915; -.
DR GeneCards; TMEM184A; -.
DR HGNC; HGNC:28797; TMEM184A.
DR HPA; ENSG00000164855; Tissue enhanced (esophagus).
DR neXtProt; NX_Q6ZMB5; -.
DR OpenTargets; ENSG00000164855; -.
DR PharmGKB; PA162406118; -.
DR VEuPathDB; HostDB:ENSG00000164855; -.
DR eggNOG; KOG2641; Eukaryota.
DR GeneTree; ENSGT00940000153861; -.
DR HOGENOM; CLU_012923_3_0_1; -.
DR InParanoid; Q6ZMB5; -.
DR OMA; CEQRYII; -.
DR OrthoDB; 1738105at2759; -.
DR PhylomeDB; Q6ZMB5; -.
DR TreeFam; TF314160; -.
DR PathwayCommons; Q6ZMB5; -.
DR SignaLink; Q6ZMB5; -.
DR BioGRID-ORCS; 202915; 164 hits in 1062 CRISPR screens.
DR ChiTaRS; TMEM184A; human.
DR GenomeRNAi; 202915; -.
DR Pharos; Q6ZMB5; Tbio.
DR PRO; PR:Q6ZMB5; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q6ZMB5; protein.
DR Bgee; ENSG00000164855; Expressed in lower esophagus mucosa and 169 other tissues.
DR ExpressionAtlas; Q6ZMB5; baseline and differential.
DR Genevisible; Q6ZMB5; HS.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0030667; C:secretory granule membrane; ISS:UniProtKB.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Cytoplasmic vesicle; Endosome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..413
FT /note="Transmembrane protein 184A"
FT /id="PRO_0000300466"
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 372..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 18
FT /note="A -> V (in dbSNP:rs17852421)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_062157"
FT VARIANT 390
FT /note="S -> G (in dbSNP:rs3779607)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060120"
FT CONFLICT 391
FT /note="G -> GG (in Ref. 3; AAH26694)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 413 AA; 45777 MW; 7107392E64DB2CB8 CRC64;
MSNVSGILET AGVPLVSANW PQPSPPPAVP AGPQMDHMGN SSQGAPWLFL TSALARGVSG
IFVWTALVLT CHQIYLHLRS YTVPQEQRYI IRLLLIVPIY AFDSWLSLLL LGDHQYYVYF
DSVRDCYEAF VIYSFLSLCF QYLGGEGAIM AEIRGKPIKS SCLYGTCCLR GMTYSIGFLR
FCKQATLQFC LVKPVMAVTT IILQAFGKYH DGDFNVRSGY LYVTLIYNAS VSLALYALFL
FYFTTRELLR PFQPVLKFLT IKAVIFLSFW QGLLLAILER CGVIPEVETS GGNKLGAGTL
AAGYQNFIIC VEMLFASVAL RYAFPCQVYA EKKENSPAPP APMQSISSGI RETVSPQDIV
QDAIHNFSPA YQHYTQQATH EAPRPGTHPS GGSGGSRKSR SLEKRMLIPS EDL
