T184A_MOUSE
ID T184A_MOUSE Reviewed; 425 AA.
AC Q3UFJ6; Q8BII8; Q8K1B0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Transmembrane protein 184A;
DE AltName: Full=Sexually dimorphic expressed in male gonads 1 {ECO:0000303|PubMed:18321981};
GN Name=Tmem184a; Synonyms=Sdmg1 {ECO:0000303|PubMed:18321981};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17616727; DOI=10.1530/rep-06-0379;
RA Svingen T., Beverdam A., Bernard P., McClive P., Harley V.R.,
RA Sinclair A.H., Koopman P.;
RT "Sex-specific expression of a novel gene Tmem184a during mouse testis
RT differentiation.";
RL Reproduction 133:983-989(2007).
RN [4]
RP SUBCELLULAR LOCATION, FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=18321981; DOI=10.1242/dev.019497;
RA Best D., Sahlender D.A., Walther N., Peden A.A., Adams I.R.;
RT "Sdmg1 is a conserved transmembrane protein associated with germ cell sex
RT determination and germline-soma interactions in mice.";
RL Development 135:1415-1425(2008).
RN [5]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=19097053; DOI=10.1002/dvdy.21827;
RA Best D., Adams I.R.;
RT "Sdmg1 is a component of secretory granules in mouse secretory exocrine
RT tissues.";
RL Dev. Dyn. 238:223-231(2009).
CC -!- FUNCTION: Acts as a heparin receptor in vascular cells (By similarity).
CC May be involved in vesicle transport in exocrine cells and Sertoli
CC cells (PubMed:18321981, PubMed:19097053).
CC {ECO:0000250|UniProtKB:Q4QQS1, ECO:0000269|PubMed:18321981,
CC ECO:0000269|PubMed:19097053}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q1RMW2};
CC Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear
CC region {ECO:0000250|UniProtKB:Q1RMW2}. Cytoplasmic vesicle membrane
CC {ECO:0000250|UniProtKB:Q1RMW2}; Multi-pass membrane protein
CC {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:18321981};
CC Multi-pass membrane protein {ECO:0000305}. Endosome
CC {ECO:0000269|PubMed:18321981, ECO:0000269|PubMed:19097053}. Cytoplasmic
CC vesicle, secretory vesicle membrane {ECO:0000269|PubMed:19097053}.
CC Note=Colocalizes with the secretory granule marker VAMP2 in pancreatic
CC acinar cells (PubMed:19097053). {ECO:0000269|PubMed:19097053}.
CC -!- TISSUE SPECIFICITY: Expressed in testis, pancreas, parotid salivary
CC gland and mammary gland (at protein level)(PubMed:17616727,
CC PubMed:19097053). {ECO:0000269|PubMed:17616727,
CC ECO:0000269|PubMed:19097053}.
CC -!- DEVELOPMENTAL STAGE: Up-regulated in the testes from 11.5 dpc until
CC 16.5 dpc, expression is maintained in the male Sertoli cells throughout
CC embryonic development and into adulthood. Not expressed in the female
CC gonad during embryonic development (PubMed:17616727, PubMed:18321981).
CC Expressed in the granulosa cells, a few days after birth, expression is
CC maintained in granulosa cells during folliculogenesis (PubMed:17616727,
CC PubMed:18321981). Up-regulated during embryonic pancreatic acinar cell
CC differentiation (PubMed:19097053). {ECO:0000269|PubMed:17616727,
CC ECO:0000269|PubMed:18321981, ECO:0000269|PubMed:19097053}.
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC34286.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK050489; BAC34286.1; ALT_INIT; mRNA.
DR EMBL; AK148454; BAE28564.1; -; mRNA.
DR EMBL; BC026659; AAH26659.1; -; mRNA.
DR CCDS; CCDS39354.1; -.
DR RefSeq; NP_001155020.1; NM_001161548.1.
DR RefSeq; NP_659163.3; NM_144914.3.
DR RefSeq; XP_006504733.1; XM_006504670.3.
DR RefSeq; XP_006504734.1; XM_006504671.1.
DR AlphaFoldDB; Q3UFJ6; -.
DR STRING; 10090.ENSMUSP00000035399; -.
DR TCDB; 2.A.82.1.10; the organic solute transporter (ost) family.
DR PhosphoSitePlus; Q3UFJ6; -.
DR PaxDb; Q3UFJ6; -.
DR PRIDE; Q3UFJ6; -.
DR ProteomicsDB; 254527; -.
DR TopDownProteomics; Q3UFJ6; -.
DR DNASU; 231832; -.
DR Ensembl; ENSMUST00000110832; ENSMUSP00000106456; ENSMUSG00000036687.
DR GeneID; 231832; -.
DR KEGG; mmu:231832; -.
DR UCSC; uc009ahe.2; mouse.
DR CTD; 202915; -.
DR MGI; MGI:2385897; Tmem184a.
DR VEuPathDB; HostDB:ENSMUSG00000036687; -.
DR eggNOG; KOG2641; Eukaryota.
DR GeneTree; ENSGT00940000153861; -.
DR HOGENOM; CLU_012923_3_0_1; -.
DR InParanoid; Q3UFJ6; -.
DR OrthoDB; 462913at2759; -.
DR PhylomeDB; Q3UFJ6; -.
DR BioGRID-ORCS; 231832; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Tmem184a; mouse.
DR PRO; PR:Q3UFJ6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q3UFJ6; protein.
DR Bgee; ENSMUSG00000036687; Expressed in epithelium of stomach and 109 other tissues.
DR ExpressionAtlas; Q3UFJ6; baseline and differential.
DR Genevisible; Q3UFJ6; MM.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; IDA:MGI.
DR GO; GO:0005768; C:endosome; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0030667; C:secretory granule membrane; IDA:UniProtKB.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
DR GO; GO:0018992; P:germ-line sex determination; IMP:MGI.
DR GO; GO:0032880; P:regulation of protein localization; IMP:MGI.
DR GO; GO:0051046; P:regulation of secretion; IMP:MGI.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Cytoplasmic vesicle; Endosome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..425
FT /note="Transmembrane protein 184A"
FT /id="PRO_0000300468"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 375..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 243
FT /note="L -> P (in Ref. 2; AAH26659)"
FT /evidence="ECO:0000305"
FT CONFLICT 345
FT /note="M -> I (in Ref. 1; BAC34286)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 46818 MW; 175D46916ECEBDFC CRC64;
MRNASGFLKT AGAPLVSATW LPPSPPPAMP TVAAGPQMER VDNGSQGAPQ LFLTSALARG
VSGVFVWTAL LLTGHQIYSH LRSYTAPREQ RFVIRLLFIV PIYAFDSWLS LLLLGGHPYY
VYFDSVRDCY EAFVIYSFLT LCFQYLGGES AIMAEIRGKP IRSSCFYGTC CLRGMSYSIT
FLRFCKQATL QFCIVKPVMA LITIILQAFD KYHDGDFNIH SGYLYVTLVY NASVSLALYA
LFLFYFATRD LLRPFEPVLK FLTIKAIIFL SFWQGMLLAI LERCGVIPEV QAVDGTRVGA
GTLAAGYQNF LICVEMLFAS LALRYAFPSQ VYSEKKNSPV PPAPMQSISS GLKETISPQD
IVQDAIHNFS PAYQQYTQQS THEAPGPGQG GHPAPSTHPG PASGSGGGKK SRNIEKRMLI
PSEDL
