T184B_BOVIN
ID T184B_BOVIN Reviewed; 407 AA.
AC A2VDL9;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Transmembrane protein 184B;
GN Name=TMEM184B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hippocampus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May activate the MAP kinase signaling pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC133301; AAI33302.1; -; mRNA.
DR RefSeq; NP_001074991.1; NM_001081522.1.
DR AlphaFoldDB; A2VDL9; -.
DR STRING; 9913.ENSBTAP00000012742; -.
DR PaxDb; A2VDL9; -.
DR PRIDE; A2VDL9; -.
DR Ensembl; ENSBTAT00000012742; ENSBTAP00000012742; ENSBTAG00000009668.
DR GeneID; 514220; -.
DR KEGG; bta:514220; -.
DR CTD; 25829; -.
DR VEuPathDB; HostDB:ENSBTAG00000009668; -.
DR VGNC; VGNC:36010; TMEM184B.
DR eggNOG; KOG2641; Eukaryota.
DR GeneTree; ENSGT00940000153861; -.
DR HOGENOM; CLU_012923_3_0_1; -.
DR InParanoid; A2VDL9; -.
DR OrthoDB; 462913at2759; -.
DR TreeFam; TF314160; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000009668; Expressed in pigment epithelium of eye and 104 other tissues.
DR ExpressionAtlas; A2VDL9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..407
FT /note="Transmembrane protein 184B"
FT /id="PRO_0000284949"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 388
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y519"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y519"
FT MOD_RES 403
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y519"
SQ SEQUENCE 407 AA; 45490 MW; 49FF012CC973916E CRC64;
MTVRGAALAP DPASPTTAAA SPSISVIPEG SPTAMEQPVF LMTTAAQAIS GFFVWTALLI
TCHQIYMHLR CYSCPNEQRY IVRILFIVPI YAFDSWLSLL FFTNDQYYVY FGTVRDCYEA
LVIYNFLSLC YEYLGGESSI MSEIRGKPIE SSCMYGTCCL WGKTYSIGFL RFCKQATLQF
CVVKPLMAVS TVVLQAFGKY RDGDFDVTSG YLYVTIIYNI SVSLALYALF LFYFATRELL
SPYSPVLKFF MVKSVIFLSF WQGMLLAILE KCGAIPKIHS ARVSVGEGTV AAGYQDFIIC
VEMFFAALAL RHAFTYKVYA DKRVDAQGRC APMKSISSSL KETMNPHDIV QDAIHNFSPA
YQQYTQQSTL EPGPTWRGGA HGLSRSHSLS GARDNEKTLL LSSDDEF
