T184B_MOUSE
ID T184B_MOUSE Reviewed; 407 AA.
AC Q8BG09; Q3TY97; Q8BJ02;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transmembrane protein 184B;
GN Name=Tmem184b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Embryo, Head, Liver, Skin, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May activate the MAP kinase signaling pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
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DR EMBL; AK028196; BAC25805.1; -; mRNA.
DR EMBL; AK029129; BAC26312.1; -; mRNA.
DR EMBL; AK048138; BAC33254.1; -; mRNA.
DR EMBL; AK149366; BAE28837.1; -; mRNA.
DR EMBL; AK158789; BAE34666.1; -; mRNA.
DR EMBL; AK170086; BAE41556.1; -; mRNA.
DR EMBL; BC046959; AAH46959.1; -; mRNA.
DR CCDS; CCDS27639.1; -.
DR RefSeq; NP_001240746.1; NM_001253817.1.
DR RefSeq; NP_001240748.1; NM_001253819.1.
DR RefSeq; NP_001240749.1; NM_001253820.1.
DR RefSeq; NP_766196.1; NM_172608.1.
DR AlphaFoldDB; Q8BG09; -.
DR STRING; 10090.ENSMUSP00000074518; -.
DR iPTMnet; Q8BG09; -.
DR PhosphoSitePlus; Q8BG09; -.
DR SwissPalm; Q8BG09; -.
DR jPOST; Q8BG09; -.
DR PaxDb; Q8BG09; -.
DR PeptideAtlas; Q8BG09; -.
DR PRIDE; Q8BG09; -.
DR ProteomicsDB; 254528; -.
DR Antibodypedia; 12345; 94 antibodies from 30 providers.
DR Ensembl; ENSMUST00000074991; ENSMUSP00000074518; ENSMUSG00000009035.
DR Ensembl; ENSMUST00000178522; ENSMUSP00000136416; ENSMUSG00000009035.
DR GeneID; 223693; -.
DR KEGG; mmu:223693; -.
DR UCSC; uc007wti.1; mouse.
DR CTD; 25829; -.
DR MGI; MGI:2445179; Tmem184b.
DR VEuPathDB; HostDB:ENSMUSG00000009035; -.
DR eggNOG; KOG2641; Eukaryota.
DR GeneTree; ENSGT00940000153861; -.
DR HOGENOM; CLU_012923_3_0_1; -.
DR InParanoid; Q8BG09; -.
DR OMA; YIYITVI; -.
DR OrthoDB; 462913at2759; -.
DR PhylomeDB; Q8BG09; -.
DR TreeFam; TF314160; -.
DR BioGRID-ORCS; 223693; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Tmem184b; mouse.
DR PRO; PR:Q8BG09; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8BG09; protein.
DR Bgee; ENSMUSG00000009035; Expressed in dorsal pancreas and 234 other tissues.
DR ExpressionAtlas; Q8BG09; baseline and differential.
DR Genevisible; Q8BG09; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..407
FT /note="Transmembrane protein 184B"
FT /id="PRO_0000211556"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 388
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y519"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y519"
FT MOD_RES 403
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y519"
FT CONFLICT 327
FT /note="Q -> QVLTYGPY (in Ref. 1; BAC33254)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 407 AA; 45589 MW; D708E141A34DEC73 CRC64;
MTVRGAALAP DPASPTTTTA SPSVSATPEG SPTAMEHPVF LMTTAAQAIS GFFVWTALLI
TCHQIYMHLR CYSRPNEQRH IVRILFIVPI YAFDSWLSLL FFTNDQYYVY FGTVRDCYEA
FVIYNFLSLC YEYLGGESAI MSEIRGKAIE SSCMYGTCCL WGKTYSIGFL RFCKQATLQF
CVVKPLMAVS TVILQAFGKY RDGDFDVTSG YLYVTIIYNI SVSLALYALF LFYFATRELL
SPYSPVLKFF MVKSVIFLSF WQGMLLAILE KCGAIPKINS ARVSVGEGTV AAGYQDFIIC
VEMFFAALAL RHAFTYKVYA DKRLDAQGRC APMKSISSSL KETMNPHDIV QDAIHNFSPA
YQQYTQQSTL EPGPTWRGGT HSLSRSHSLS GARDNEKTLL LSSDDEF
