T184C_HUMAN
ID T184C_HUMAN Reviewed; 438 AA.
AC Q9NVA4; D3DP04; Q86X84; Q969I7; Q9NXM2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Transmembrane protein 184C;
DE AltName: Full=Transmembrane protein 34;
GN Name=TMEM184C; Synonyms=TMEM34; ORFNames=PRO1355;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 301-438 (ISOFORM 1).
RC TISSUE=Lung, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-438 (ISOFORM 1).
RC TISSUE=Fetal liver;
RX PubMed=11483580; DOI=10.1101/gr.175501;
RA Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C., Zhai Y.,
RA Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C., He F.;
RT "Gene expression profiling in human fetal liver and identification of
RT tissue- and developmental-stage-specific genes through compiled expression
RT profiles and efficient cloning of full-length cDNAs.";
RL Genome Res. 11:1392-1403(2001).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17072649; DOI=10.1007/s00432-006-0159-8;
RA Akaishi J., Onda M., Okamoto J., Miyamoto S., Nagahama M., Ito K.,
RA Yoshida A., Shimizu K.;
RT "Down-regulation of an inhibitor of cell growth, transmembrane protein 34
RT (TMEM34), in anaplastic thyroid cancer.";
RL J. Cancer Res. Clin. Oncol. 133:213-218(2007).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Possible tumor suppressor which may play a role in cell
CC growth. {ECO:0000269|PubMed:17072649}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NVA4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NVA4-2; Sequence=VSP_025566;
CC -!- TISSUE SPECIFICITY: Widely expressed with higher expression in lung,
CC kidney, spleen, pancreas, thymus, prostate, testis, ovary, small
CC intestine and thyroid. {ECO:0000269|PubMed:17072649}.
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK55526.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA90988.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK000169; BAA90988.1; ALT_INIT; mRNA.
DR EMBL; AK001708; BAA91851.1; -; mRNA.
DR EMBL; BC008120; AAH08120.1; -; mRNA.
DR EMBL; BC046128; AAH46128.1; -; mRNA.
DR EMBL; AC093835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471056; EAX05015.1; -; Genomic_DNA.
DR EMBL; CH471056; EAX05016.1; -; Genomic_DNA.
DR EMBL; AF305823; AAK55526.1; ALT_INIT; mRNA.
DR CCDS; CCDS3770.1; -. [Q9NVA4-1]
DR RefSeq; NP_060711.2; NM_018241.2. [Q9NVA4-1]
DR AlphaFoldDB; Q9NVA4; -.
DR BioGRID; 120869; 8.
DR IntAct; Q9NVA4; 6.
DR MINT; Q9NVA4; -.
DR STRING; 9606.ENSP00000296582; -.
DR iPTMnet; Q9NVA4; -.
DR PhosphoSitePlus; Q9NVA4; -.
DR SwissPalm; Q9NVA4; -.
DR BioMuta; TMEM184C; -.
DR DMDM; 296452918; -.
DR EPD; Q9NVA4; -.
DR jPOST; Q9NVA4; -.
DR MassIVE; Q9NVA4; -.
DR MaxQB; Q9NVA4; -.
DR PaxDb; Q9NVA4; -.
DR PeptideAtlas; Q9NVA4; -.
DR PRIDE; Q9NVA4; -.
DR ProteomicsDB; 82773; -. [Q9NVA4-1]
DR Antibodypedia; 45494; 61 antibodies from 19 providers.
DR DNASU; 55751; -.
DR Ensembl; ENST00000296582.8; ENSP00000296582.3; ENSG00000164168.8. [Q9NVA4-1]
DR GeneID; 55751; -.
DR KEGG; hsa:55751; -.
DR MANE-Select; ENST00000296582.8; ENSP00000296582.3; NM_018241.3; NP_060711.2.
DR UCSC; uc003ila.5; human. [Q9NVA4-1]
DR CTD; 55751; -.
DR DisGeNET; 55751; -.
DR GeneCards; TMEM184C; -.
DR HGNC; HGNC:25587; TMEM184C.
DR HPA; ENSG00000164168; Tissue enriched (parathyroid).
DR MIM; 613937; gene.
DR neXtProt; NX_Q9NVA4; -.
DR OpenTargets; ENSG00000164168; -.
DR PharmGKB; PA162406163; -.
DR VEuPathDB; HostDB:ENSG00000164168; -.
DR eggNOG; KOG2641; Eukaryota.
DR GeneTree; ENSGT00940000155201; -.
DR HOGENOM; CLU_012923_1_1_1; -.
DR InParanoid; Q9NVA4; -.
DR OMA; QKWIVAV; -.
DR OrthoDB; 462913at2759; -.
DR PhylomeDB; Q9NVA4; -.
DR TreeFam; TF324245; -.
DR PathwayCommons; Q9NVA4; -.
DR SignaLink; Q9NVA4; -.
DR BioGRID-ORCS; 55751; 31 hits in 1077 CRISPR screens.
DR ChiTaRS; TMEM184C; human.
DR GenomeRNAi; 55751; -.
DR Pharos; Q9NVA4; Tdark.
DR PRO; PR:Q9NVA4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9NVA4; protein.
DR Bgee; ENSG00000164168; Expressed in parotid gland and 192 other tissues.
DR ExpressionAtlas; Q9NVA4; baseline and differential.
DR Genevisible; Q9NVA4; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..438
FT /note="Transmembrane protein 184C"
FT /id="PRO_0000287567"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 355..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 422
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 262..438
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025566"
FT CONFLICT 230
FT /note="L -> P (in Ref. 1; BAA90988)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="K -> R (in Ref. 1; BAA91851)"
FT /evidence="ECO:0000305"
FT CONFLICT 261
FT /note="Q -> P (in Ref. 4; AAH46128)"
FT /evidence="ECO:0000305"
FT CONFLICT 355
FT /note="R -> G (in Ref. 1; BAA91851)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 438 AA; 50142 MW; 60EF5C2B0C6FD296 CRC64;
MPCTCTWRNW RQWIRPLVAV IYLVSIVVAV PLCVWELQKL EVGIHTKAWF IAGIFLLLTI
PISLWVILQH LVHYTQPELQ KPIIRILWMV PIYSLDSWIA LKYPGIAIYV DTCRECYEAY
VIYNFMGFLT NYLTNRYPNL VLILEAKDQQ KHFPPLCCCP PWAMGEVLLF RCKLGVLQYT
VVRPFTTIVA LICELLGIYD EGNFSFSNAW TYLVIINNMS QLFAMYCLLL FYKVLKEELS
PIQPVGKFLC VKLVVFVSFW QAVVIALLVK VGVISEKHTW EWQTVEAVAT GLQDFIICIE
MFLAAIAHHY TFSYKPYVQE AEEGSCFDSF LAMWDVSDIR DDISEQVRHV GRTVRGHPRK
KLFPEDQDQN EHTSLLSSSS QDAISIASSM PPSPMGHYQG FGHTVTPQTT PTTAKISDEI
LSDTIGEKKE PSDKSVDS
