T184C_MOUSE
ID T184C_MOUSE Reviewed; 525 AA.
AC Q3TPR7; Q8CCD2; Q99KQ7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Transmembrane protein 184C;
DE AltName: Full=Transmembrane protein 34;
GN Name=Tmem184c; Synonyms=Tmem34;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Possible tumor suppressor which may play a role in cell
CC growth. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3TPR7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TPR7-2; Sequence=VSP_025567;
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
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DR EMBL; AK033404; BAC28273.1; -; mRNA.
DR EMBL; AK164182; BAE37668.1; -; mRNA.
DR EMBL; BC004056; AAH04056.1; -; mRNA.
DR CCDS; CCDS22426.1; -. [Q3TPR7-2]
DR RefSeq; NP_663574.3; NM_145599.4. [Q3TPR7-2]
DR AlphaFoldDB; Q3TPR7; -.
DR iPTMnet; Q3TPR7; -.
DR PhosphoSitePlus; Q3TPR7; -.
DR MaxQB; Q3TPR7; -.
DR PRIDE; Q3TPR7; -.
DR ProteomicsDB; 263225; -. [Q3TPR7-1]
DR ProteomicsDB; 263226; -. [Q3TPR7-2]
DR Antibodypedia; 45494; 61 antibodies from 19 providers.
DR Ensembl; ENSMUST00000034030; ENSMUSP00000034030; ENSMUSG00000031617. [Q3TPR7-2]
DR GeneID; 234463; -.
DR KEGG; mmu:234463; -.
DR UCSC; uc009mhr.3; mouse. [Q3TPR7-2]
DR CTD; 55751; -.
DR MGI; MGI:2384562; Tmem184c.
DR VEuPathDB; HostDB:ENSMUSG00000031617; -.
DR GeneTree; ENSGT00940000155201; -.
DR HOGENOM; CLU_012923_1_1_1; -.
DR InParanoid; Q3TPR7; -.
DR OMA; MIDTSES; -.
DR OrthoDB; 462913at2759; -.
DR PhylomeDB; Q3TPR7; -.
DR TreeFam; TF324245; -.
DR BioGRID-ORCS; 234463; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Tmem184c; mouse.
DR PRO; PR:Q3TPR7; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3TPR7; protein.
DR Bgee; ENSMUSG00000031617; Expressed in lateral geniculate body and 250 other tissues.
DR ExpressionAtlas; Q3TPR7; baseline and differential.
DR Genevisible; Q3TPR7; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..525
FT /note="Transmembrane protein 184C"
FT /id="PRO_0000287568"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 358..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 438
FT /note="T -> TINIPEEQQKLNTGKDVMLDRQTITSPRPISIASIYEKIMIDIPEEQ
FT QKLTDTGQDVMINRQTITPPRPISITSIYEEVLIDITEKQQKLNDTGKNVM (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_025567"
FT CONFLICT 483
FT /note="L -> F (in Ref. 1; BAC28273)"
FT /evidence="ECO:0000305"
FT CONFLICT Q3TPR7-2:475
FT /note="K -> E (in Ref. 2; AAH04056)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 525 AA; 60043 MW; 1D2C7AFBB03A6954 CRC64;
MPCACNRSNW RRWIRPLLVL FYATTILVAV PICIWKFQKM KVGMHTKSWF IAGIFLLLTI
PVSLWGILQH LVHYTQPELQ KPIIRILWMV PIYSVDSWVA LVYPKIAIYV DTWRECYEAY
VIYNFMIFLT NYLTIRFPNL ILHLEAKDQQ NHILPLCCCP PWAMGEMLLF RCKLGVLQYT
VVRPITTVTA LVCEILDVYD EGNFGFSNAW TYLVILNNLS QLFAMYCLLL FYKVLKEELS
PIQPVGKFLC VKLVVFVSFW QAVLIALLVK LGVISEKRTW EWQSAEAVAT GLQDFIICIE
MFFAAIAHHY TFSYKPYVHE AEEGSCFDSF LAMWDVSDIR DDISEQVRRV GRTMRGYPKK
KCFPGDPDHN EHSSLLSSSS QDLTSGSSKV PSPGGLYQGF GHTISSQSPI SIASIYEEIM
NDIPEEQQKL LNPGQDVTIN IPEEQQKLID KRKDVMIDIP EQNAIPDNSQ YQDQEQIVTL
QALFPSTETS ENSMIDTSES QQESSDLCTE SSDSSTESSD LSTDP