ID   T184C_PONAB             Reviewed;         438 AA.
AC   Q5RET6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Transmembrane protein 184C;
DE   AltName: Full=Transmembrane protein 34;
GN   Name=TMEM184C; Synonyms=TMEM34;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible tumor suppressor which may play a role in cell
CC       growth. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
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DR   EMBL; CR857430; CAH89721.1; -; mRNA.
DR   RefSeq; NP_001127187.1; NM_001133715.1.
DR   AlphaFoldDB; Q5RET6; -.
DR   GeneID; 100174241; -.
DR   KEGG; pon:100174241; -.
DR   CTD; 55751; -.
DR   InParanoid; Q5RET6; -.
DR   OrthoDB; 462913at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR005178; Ostalpha/TMEM184C.
DR   PANTHER; PTHR23423; PTHR23423; 1.
DR   Pfam; PF03619; Solute_trans_a; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..438
FT                   /note="Transmembrane protein 184C"
FT                   /id="PRO_0000287569"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          358..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..419
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..438
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         422
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVA4"
SQ   SEQUENCE   438 AA;  50161 MW;  60F4E630ADD5C92C CRC64;
     MPCTCTWRNW RQWIRPLVAV IYLVSIVVAV PLCVWELQKL EVGIHTKAWF IAGIFLLLTI
     PISLWVILQH LVHYTQPELQ KPIIRILWMV PIYSLDSWIA LKYPGIAIYV DTCRECYEAY
     VIYNFMGFLT NYLTNRYPNL VLILEAKDQQ KHFPPLCCCP PWAMGEVLLF RCKLGVLQYT
     VVRPFTTIVA LICELLGIYD EGNFSFSNAW TYLVIINNMS QLFAMYCLLL FYKVLKEELS
     PIQPVGKFLC VKLVVFVSFW QAVVIALLVK VGVISEKHTW EWQTVEAVAT GLQDFIICIE
     MFLAAIAHHY TFSYKPYVQE AEEGSCFDSF LAMWDVSDIR DDISEQVRRV GRTVRGHPRK
     KLFPEDQDQN EHTSLLSSSS QDAISIASSM PPSPMGHYQG FGHTVTPQTT PTTAKISDEI
     LSDTIGEKKE PSDKSVDS