T185A_MOUSE
ID T185A_MOUSE Reviewed; 350 AA.
AC A2AF53;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Transmembrane protein 185A;
DE AltName: Full=Erythropoietin-induced EST 3;
DE AltName: Full=Protein FAM11A;
GN Name=Tmem185a; Synonyms=Ee3, Fam11a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP INDUCTION BY ERYTHROPOIETIN.
RX PubMed=15525354; DOI=10.1111/j.1471-4159.2004.02799.x;
RA Maurer M.H., Gruenewald S., Gassler N., Rossner M., Propst F., Wuerz R.,
RA Weber D., Kuner T., Kuschinsky W., Schneider A.;
RT "Cloning of a novel neuronally expressed orphan G-protein-coupled receptor
RT which is up-regulated by erythropoietin, interacts with microtubule-
RT associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a
RT receptor.";
RL J. Neurochem. 91:1007-1017(2004).
CC -!- SUBUNIT: Interacts with MAP1B. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000269|PubMed:15525354}. Membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Broadly expressed in brain where it is specifically
CC expressed by neurons (at protein level). Also detected in some cells of
CC arterioles, intestine, lung and testis (at protein level).
CC {ECO:0000269|PubMed:15525354}.
CC -!- DEVELOPMENTAL STAGE: Detected at 7 dpc, levels increase from 11 dpc to
CC 17 dpc. {ECO:0000269|PubMed:15525354}.
CC -!- INDUCTION: Up-regulated by erythropoietin (at protein level).
CC {ECO:0000269|PubMed:15525354}.
CC -!- SIMILARITY: Belongs to the TMEM185 family. {ECO:0000305}.
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DR EMBL; AL672026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC138670; AAI38671.1; -; mRNA.
DR EMBL; BC145368; AAI45369.1; -; mRNA.
DR CCDS; CCDS90721.1; -.
DR RefSeq; XP_006528044.1; XM_006527981.2.
DR AlphaFoldDB; A2AF53; -.
DR STRING; 10090.ENSMUSP00000099043; -.
DR iPTMnet; A2AF53; -.
DR PhosphoSitePlus; A2AF53; -.
DR PRIDE; A2AF53; -.
DR ProteomicsDB; 254804; -.
DR Antibodypedia; 74111; 57 antibodies from 17 providers.
DR Ensembl; ENSMUST00000114630; ENSMUSP00000110277; ENSMUSG00000073139.
DR UCSC; uc012hjm.1; mouse.
DR MGI; MGI:2448555; Tmem185a.
DR VEuPathDB; HostDB:ENSMUSG00000073139; -.
DR eggNOG; KOG3879; Eukaryota.
DR GeneTree; ENSGT00940000158388; -.
DR HOGENOM; CLU_053027_0_0_1; -.
DR InParanoid; A2AF53; -.
DR OMA; HEFGKHD; -.
DR OrthoDB; 554512at2759; -.
DR PhylomeDB; A2AF53; -.
DR BioGRID-ORCS; 236848; 1 hit in 58 CRISPR screens.
DR ChiTaRS; Tmem185a; mouse.
DR PRO; PR:A2AF53; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; A2AF53; protein.
DR Bgee; ENSMUSG00000073139; Expressed in primitive streak and 253 other tissues.
DR ExpressionAtlas; A2AF53; baseline and differential.
DR GO; GO:0030425; C:dendrite; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR PANTHER; PTHR13568; PTHR13568; 1.
DR Pfam; PF10269; Tmemb_185A; 1.
PE 1: Evidence at protein level;
KW Cell projection; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..350
FT /note="Transmembrane protein 185A"
FT /id="PRO_0000423780"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 298..350
FT /note="Mediates interaction with MAP1B"
FT /evidence="ECO:0000250"
SQ SEQUENCE 350 AA; 40620 MW; 13FFC0BA9F8328B4 CRC64;
MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW KLMVIVGASV
GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL VCDRIERGSH FWLLVFMPLF
FVSPVSVAAC VWGFRHDRSL ELEILCSVNI LQFIFIALRL DKIIHWPWLV VCVPLWILMS
FLCLVVLYYI VWSVLFLRSM DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA
FSCIPIFVPL WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH
HEDSEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYVLP PPKLNIEMPD
