ID   T185A_PONAB             Reviewed;         350 AA.
AC   Q5R8H8;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Transmembrane protein 185A;
DE   AltName: Full=Protein FAM11A;
GN   Name=TMEM185A; Synonyms=FAM11A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with MAP1B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000250}. Membrane
CC       {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM185 family. {ECO:0000305}.
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DR   EMBL; CR859774; CAH91932.1; -; mRNA.
DR   RefSeq; NP_001126120.1; NM_001132648.1.
DR   AlphaFoldDB; Q5R8H8; -.
DR   STRING; 9601.ENSPPYP00000023293; -.
DR   GeneID; 100173076; -.
DR   KEGG; pon:100173076; -.
DR   CTD; 84548; -.
DR   eggNOG; KOG3879; Eukaryota.
DR   InParanoid; Q5R8H8; -.
DR   OrthoDB; 554512at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR   PANTHER; PTHR13568; PTHR13568; 1.
DR   Pfam; PF10269; Tmemb_185A; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..350
FT                   /note="Transmembrane protein 185A"
FT                   /id="PRO_0000188008"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          298..350
FT                   /note="Mediates interaction with MAP1B"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   350 AA;  40677 MW;  AAAA1147A1E802C2 CRC64;
     MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW KLMVIVGASV
     GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL VCDRIERGSH FWLLVFMPLF
     FVSPVSVAAC VWDFRHDRSL ELEILCSVNI LQFIFIALRL DKIIHWPWLV VCVPLWILMS
     FLCLVVLYYI VWSVLFLRSM DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA
     FSCIPIFVPL WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH
     HEDNEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYALP PPKLNIEMPD