ID   T185B_BOVIN             Reviewed;         350 AA.
AC   Q08DE2;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Transmembrane protein 185B;
DE   AltName: Full=Protein FAM11B;
GN   Name=TMEM185B; Synonyms=FAM11B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM185 family. {ECO:0000305}.
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DR   EMBL; BC123796; AAI23797.1; -; mRNA.
DR   RefSeq; NP_001071436.1; NM_001077968.1.
DR   AlphaFoldDB; Q08DE2; -.
DR   STRING; 9913.ENSBTAP00000050866; -.
DR   PaxDb; Q08DE2; -.
DR   Ensembl; ENSBTAT00000038352; ENSBTAP00000050866; ENSBTAG00000026829.
DR   GeneID; 526189; -.
DR   KEGG; bta:526189; -.
DR   CTD; 79134; -.
DR   VEuPathDB; HostDB:ENSBTAG00000026829; -.
DR   VGNC; VGNC:36012; TMEM185B.
DR   eggNOG; KOG3879; Eukaryota.
DR   GeneTree; ENSGT00940000163000; -.
DR   HOGENOM; CLU_053027_0_0_1; -.
DR   InParanoid; Q08DE2; -.
DR   OMA; PWTIVFC; -.
DR   OrthoDB; 554512at2759; -.
DR   TreeFam; TF313829; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000026829; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR   PANTHER; PTHR13568; PTHR13568; 1.
DR   Pfam; PF10269; Tmemb_185A; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..350
FT                   /note="Transmembrane protein 185B"
FT                   /id="PRO_0000278795"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   350 AA;  40659 MW;  513146033A44EDE5 CRC64;
     MNPRGLFQDF NPSKFLIYAC LLLFSVLLPL RLDGVIQWSY WAVFAPIWLW KLLVLAGASV
     GAGVWARNPR YRTEGEACVE FKAMLIAVGI HLLLLMFEVL VCDRVERGTH FWLLVFMPLF
     FVSPVSVAAC VWGFRHDRSL ELEILCSVNI LQFIFIALRL DRIIHWPWLV VFVPLWILMS
     FLCLVVLYYI VWSLLFLRSL DVVAEQRRTH VTMAICWITI VVPLLIFEVL LVHRLDGHNM
     FSYISIFVPL WLSLITLMAT TFRRKGGNHW WFGIRRDFCQ FLLEIFPFLR EYGNISYDLH
     HEDSEDAEET SAPEAPKIAP MFGKKARVVI TQSPGKYVPP PPKLNIDMPD