T185B_HUMAN
ID T185B_HUMAN Reviewed; 350 AA.
AC Q9H7F4; A8K1G5; Q53T33; Q66K44; Q8IZ77;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Transmembrane protein 185B;
DE AltName: Full=Protein FAM11B;
GN Name=TMEM185B; Synonyms=FAM11B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adipose tissue, and Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM185 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14938.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK024632; BAB14938.1; ALT_FRAME; mRNA.
DR EMBL; AK289880; BAF82569.1; -; mRNA.
DR EMBL; AC012363; AAY14799.1; -; Genomic_DNA.
DR EMBL; BC016849; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC080607; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS58722.1; -.
DR RefSeq; NP_077026.2; NM_024121.2.
DR AlphaFoldDB; Q9H7F4; -.
DR BioGRID; 122555; 3.
DR IntAct; Q9H7F4; 1.
DR STRING; 9606.ENSP00000453399; -.
DR iPTMnet; Q9H7F4; -.
DR PhosphoSitePlus; Q9H7F4; -.
DR BioMuta; TMEM185B; -.
DR DMDM; 50400653; -.
DR jPOST; Q9H7F4; -.
DR MassIVE; Q9H7F4; -.
DR MaxQB; Q9H7F4; -.
DR PaxDb; Q9H7F4; -.
DR PeptideAtlas; Q9H7F4; -.
DR PRIDE; Q9H7F4; -.
DR ProteomicsDB; 81120; -.
DR DNASU; 79134; -.
DR Ensembl; ENST00000426077.3; ENSP00000453399.1; ENSG00000226479.4.
DR GeneID; 79134; -.
DR KEGG; hsa:79134; -.
DR MANE-Select; ENST00000426077.3; ENSP00000453399.1; NM_024121.3; NP_077026.2.
DR UCSC; uc002tmj.3; human.
DR CTD; 79134; -.
DR GeneCards; TMEM185B; -.
DR HGNC; HGNC:18896; TMEM185B.
DR HPA; ENSG00000226479; Low tissue specificity.
DR neXtProt; NX_Q9H7F4; -.
DR OpenTargets; ENSG00000226479; -.
DR PharmGKB; PA166048952; -.
DR VEuPathDB; HostDB:ENSG00000226479; -.
DR eggNOG; KOG3879; Eukaryota.
DR GeneTree; ENSGT00940000163000; -.
DR HOGENOM; CLU_053027_0_0_1; -.
DR InParanoid; Q9H7F4; -.
DR OMA; PWTIVFC; -.
DR OrthoDB; 554512at2759; -.
DR PhylomeDB; Q9H7F4; -.
DR TreeFam; TF313829; -.
DR PathwayCommons; Q9H7F4; -.
DR SignaLink; Q9H7F4; -.
DR BioGRID-ORCS; 79134; 12 hits in 1081 CRISPR screens.
DR ChiTaRS; TMEM185B; human.
DR GenomeRNAi; 79134; -.
DR Pharos; Q9H7F4; Tdark.
DR PRO; PR:Q9H7F4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9H7F4; protein.
DR Bgee; ENSG00000226479; Expressed in secondary oocyte and 179 other tissues.
DR Genevisible; Q9H7F4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR PANTHER; PTHR13568; PTHR13568; 1.
DR Pfam; PF10269; Tmemb_185A; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..350
FT /note="Transmembrane protein 185B"
FT /id="PRO_0000188009"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 42
FT /note="A -> G (in Ref. 3; BC080607)"
FT /evidence="ECO:0000305"
FT CONFLICT 59
FT /note="S -> F (in Ref. 1; BAB14938)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="E -> G (in Ref. 1; BAF82569)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 350 AA; 40599 MW; 52A7752F37AB62E2 CRC64;
MNPRGLFQDF NPSKFLIYTC LLLFSVLLPL RLDGIIQWSY WAVFAPIWLW KLLVVAGASV
GAGVWARNPR YRTEGEACVE FKAMLIAVGI HLLLLMFEVL VCDRVERGTH FWLLVFMPLF
FVSPVSVAAC VWGFRHDRSL ELEILCSVNI LQFIFIALKL DRIIHWPWLV VFVPLWILMS
FLCLVVLYYI VWSLLFLRSL DVVAEQRRTH VTMAISWITI VVPLLTFEVL LVHRLDGHNT
FSYVSIFVPL WLSLLTLMAT TFRRKGGNHW WFGIRRDFCQ FLLEIFPFLR EYGNISYDLH
HEDSEDAEET SVPEAPKIAP IFGKKARVVI TQSPGKYVPP PPKLNIDMPD
