T185B_MOUSE
ID T185B_MOUSE Reviewed; 350 AA.
AC Q8R3R5; Q8BSP3;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Transmembrane protein 185B;
DE AltName: Full=Erythropoietin-induced EST 3-2;
DE AltName: Full=Protein FAM11B;
GN Name=Tmem185b; Synonyms=Ee3-2, Fam11b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Forelimb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=15525354; DOI=10.1111/j.1471-4159.2004.02799.x;
RA Maurer M.H., Gruenewald S., Gassler N., Rossner M., Propst F., Wuerz R.,
RA Weber D., Kuner T., Kuschinsky W., Schneider A.;
RT "Cloning of a novel neuronally expressed orphan G-protein-coupled receptor
RT which is up-regulated by erythropoietin, interacts with microtubule-
RT associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a
RT receptor.";
RL J. Neurochem. 91:1007-1017(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM185 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC27267.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK031130; BAC27267.1; ALT_FRAME; mRNA.
DR EMBL; BC024712; AAH24712.1; -; mRNA.
DR CCDS; CCDS69932.1; -.
DR RefSeq; NP_666215.1; NM_146103.2.
DR AlphaFoldDB; Q8R3R5; -.
DR STRING; 10090.ENSMUSP00000139021; -.
DR iPTMnet; Q8R3R5; -.
DR PhosphoSitePlus; Q8R3R5; -.
DR SwissPalm; Q8R3R5; -.
DR EPD; Q8R3R5; -.
DR PRIDE; Q8R3R5; -.
DR ProteomicsDB; 254529; -.
DR Ensembl; ENSMUST00000183952; ENSMUSP00000139021; ENSMUSG00000098923.
DR GeneID; 226351; -.
DR KEGG; mmu:226351; -.
DR UCSC; uc007ciu.2; mouse.
DR CTD; 79134; -.
DR MGI; MGI:1917634; Tmem185b.
DR VEuPathDB; HostDB:ENSMUSG00000098923; -.
DR eggNOG; KOG3879; Eukaryota.
DR GeneTree; ENSGT00940000163000; -.
DR HOGENOM; CLU_053027_0_0_1; -.
DR InParanoid; Q8R3R5; -.
DR OMA; PWTIVFC; -.
DR OrthoDB; 554512at2759; -.
DR PhylomeDB; Q8R3R5; -.
DR BioGRID-ORCS; 226351; 2 hits in 66 CRISPR screens.
DR ChiTaRS; Tmem185b; mouse.
DR PRO; PR:Q8R3R5; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8R3R5; protein.
DR Bgee; ENSMUSG00000098923; Expressed in humerus cartilage element and 240 other tissues.
DR Genevisible; Q8R3R5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR PANTHER; PTHR13568; PTHR13568; 1.
DR Pfam; PF10269; Tmemb_185A; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..350
FT /note="Transmembrane protein 185B"
FT /id="PRO_0000188010"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 350 AA; 40701 MW; 4DE49C610BEF6614 CRC64;
MNPRGLFQDF NPSKFLIYAC LLLFSVLLPL RLDGIIQWSY WAVFAPIWLW KLLVIVGASV
GAGVWARNPR YRTEGEACVE FKAMLIAVGI HLLLLMFEIL VCDRVERGTH FWLLVFMPLF
FVSPVSVAAC VWGFRHDRSL ELEILCSVNI LQFIFIALRL DRIIHWPWLV VFVPLWILMS
FLCLVVLYYI VWSLLFLRSL DVVAEQRRTH VTMAISWITI VVPLLIFEVL LVHRLDDHNT
FSYISIFIPL WLSLLTLMAT TFRRKGGNHW WFGIRRDFCQ FLLEVFPFLR EYGNISYDLH
HEDSEDAEDA SVSEAPKIAP MFGKKARVVI TQSPGKYVPP PPKLNIDMPD
