ID   T185L_DANRE             Reviewed;         351 AA.
AC   Q7SYC7;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Transmembrane protein 185-like;
GN   ORFNames=zgc:63572;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM185 family. {ECO:0000305}.
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DR   EMBL; BC054917; AAH54917.1; -; mRNA.
DR   RefSeq; NP_956731.1; NM_200437.1.
DR   AlphaFoldDB; Q7SYC7; -.
DR   STRING; 7955.ENSDARP00000065103; -.
DR   PaxDb; Q7SYC7; -.
DR   Ensembl; ENSDART00000065104; ENSDARP00000065103; ENSDARG00000044327.
DR   GeneID; 393409; -.
DR   KEGG; dre:393409; -.
DR   CTD; 393409; -.
DR   ZFIN; ZDB-GENE-040426-1167; tmem185.
DR   eggNOG; KOG3879; Eukaryota.
DR   GeneTree; ENSGT00940000158388; -.
DR   HOGENOM; CLU_053027_0_0_1; -.
DR   InParanoid; Q7SYC7; -.
DR   OMA; HEFGKHD; -.
DR   OrthoDB; 554512at2759; -.
DR   PhylomeDB; Q7SYC7; -.
DR   TreeFam; TF313829; -.
DR   PRO; PR:Q7SYC7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000044327; Expressed in pharyngeal gill and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR   PANTHER; PTHR13568; PTHR13568; 1.
DR   Pfam; PF10269; Tmemb_185A; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..351
FT                   /note="Transmembrane protein 185-like"
FT                   /id="PRO_0000188011"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   351 AA;  40684 MW;  1F3AA585773EA0BC CRC64;
     MNLRGVFQDF NPSKFLIYAC LLLFSVLLSL RLDGIIQWSY WAVFAPIWLW KLMVIIGASV
     GTGVWAHNPQ YRAEGETCVE FKAMLIAVGI HLLLLTFEVL VCERVERASI PYWLLVFMPL
     FFVSPVSVAA CVWGFRHDRS LELEILCSVN ILQFIFIALK LDGIISWPWL VVCVPLWILM
     SFLCLVVLYY IVWSVLFLRS MDVIAEQRRT HITMAISWMT IVVPLLTFEI LLVHKLDNHY
     SPNYVPVFVP LWVSLVTLMV TTFGQKGGNH WWFGIRKDFC QFLLELFPFL REYGNISYDL
     HHEDSDMSEE LPIHEVPKIP TMFRKKTGVV ITQSPGKYFV PPPKLCIDMP D