T191B_HUMAN
ID T191B_HUMAN Reviewed; 346 AA.
AC P0C7N4; A0A087WXW8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2015, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Transmembrane protein 191B {ECO:0000312|HGNC:HGNC:33600};
GN Name=TMEM191B {ECO:0000312|HGNC:HGNC:33600};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM191 family. {ECO:0000305}.
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DR EMBL; AC023490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS74816.1; -.
DR RefSeq; NP_001229242.1; NM_001242313.1.
DR AlphaFoldDB; P0C7N4; -.
DR SMR; P0C7N4; -.
DR STRING; 9606.ENSP00000481358; -.
DR iPTMnet; P0C7N4; -.
DR PhosphoSitePlus; P0C7N4; -.
DR BioMuta; TMEM191B; -.
DR MassIVE; P0C7N4; -.
DR PeptideAtlas; P0C7N4; -.
DR PRIDE; P0C7N4; -.
DR DNASU; 728229; -.
DR Ensembl; ENST00000612978.5; ENSP00000481358.1; ENSG00000278558.5.
DR GeneID; 728229; -.
DR KEGG; hsa:728229; -.
DR MANE-Select; ENST00000612978.5; ENSP00000481358.1; NM_001242313.1; NP_001229242.1.
DR UCSC; uc021wlv.2; human.
DR CTD; 728229; -.
DR GeneCards; TMEM191B; -.
DR HGNC; HGNC:33600; TMEM191B.
DR HPA; ENSG00000278558; Tissue enriched (testis).
DR neXtProt; NX_P0C7N4; -.
DR OpenTargets; ENSG00000278558; -.
DR VEuPathDB; HostDB:ENSG00000278558; -.
DR eggNOG; ENOG502TDZY; Eukaryota.
DR GeneTree; ENSGT00390000009363; -.
DR HOGENOM; CLU_921211_0_0_1; -.
DR InParanoid; P0C7N4; -.
DR OMA; RRCAGNA; -.
DR OrthoDB; 1229595at2759; -.
DR PathwayCommons; P0C7N4; -.
DR BioGRID-ORCS; 728229; 12 hits in 181 CRISPR screens.
DR ChiTaRS; TMEM191B; human.
DR Pharos; P0C7N4; Tdark.
DR PRO; PR:P0C7N4; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; P0C7N4; protein.
DR Bgee; ENSG00000278558; Expressed in left testis and 85 other tissues.
DR ExpressionAtlas; P0C7N4; baseline and differential.
DR Genevisible; P0C7N4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028186; TMEM191B/C.
DR PANTHER; PTHR38498; PTHR38498; 1.
DR Pfam; PF15194; TMEM191C; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..346
FT /note="Transmembrane protein 191B"
FT /id="PRO_0000340716"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 101..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 52..206
FT /evidence="ECO:0000255"
SQ SEQUENCE 346 AA; 39065 MW; EFBC86689D3405B9 CRC64;
MCRATLGLPL PPIVIQPARR SLPPIVTPAS RRLGPRGGRH LGSVSTAMAA TQELLLQLQK
DNRDGRQRKQ ELEKLMRGLE AESESLNQRL QDLSERERSL LRRRSQAAQP LQGEAREAAR
ERAERVRRRL EEAERHKEDL EQHSRQLQEQ WEELSSQLFY GGEPQSQKST EQQLAAQLVT
LQNELELAET KCALQEEKLQ QDALQTAEAW AIFQEQTVVL QVRPHSDAKV PPASPPPDLG
RCDGQLRGVQ YSTESLMEEM ARADRETRLF GGPRALAIRR CVLGALQVLL TLPLLFLGLS
LLWTVLLDPG AVSAWLWSLT SETTLRRLRY TLSPLLELRA NGLLPT
