T191C_HUMAN
ID T191C_HUMAN Reviewed; 347 AA.
AC A6NGB0;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2015, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Transmembrane protein 191C {ECO:0000312|HGNC:HGNC:33601};
GN Name=TMEM191C {ECO:0000312|HGNC:HGNC:33601};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM191 family. {ECO:0000305}.
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DR EMBL; AP000557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001193981.1; NM_001207052.1.
DR AlphaFoldDB; A6NGB0; -.
DR SMR; A6NGB0; -.
DR iPTMnet; A6NGB0; -.
DR PhosphoSitePlus; A6NGB0; -.
DR BioMuta; TMEM191C; -.
DR MassIVE; A6NGB0; -.
DR PeptideAtlas; A6NGB0; -.
DR PRIDE; A6NGB0; -.
DR ProteomicsDB; 1113; -.
DR DNASU; 645426; -.
DR Ensembl; ENST00000621561.5; ENSP00000489706.2; ENSG00000206140.12.
DR GeneID; 645426; -.
DR KEGG; hsa:645426; -.
DR UCSC; uc062bjc.1; human.
DR CTD; 645426; -.
DR GeneCards; TMEM191C; -.
DR HGNC; HGNC:33601; TMEM191C.
DR HPA; ENSG00000206140; Tissue enriched (testis).
DR neXtProt; NX_A6NGB0; -.
DR VEuPathDB; HostDB:ENSG00000206140; -.
DR InParanoid; A6NGB0; -.
DR OMA; AKHAMQA; -.
DR OrthoDB; 1229595at2759; -.
DR SignaLink; A6NGB0; -.
DR BioGRID-ORCS; 645426; 8 hits in 191 CRISPR screens.
DR ChiTaRS; TMEM191C; human.
DR Pharos; A6NGB0; Tdark.
DR PRO; PR:A6NGB0; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; A6NGB0; protein.
DR Bgee; ENSG00000206140; Expressed in right testis and 91 other tissues.
DR ExpressionAtlas; A6NGB0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028186; TMEM191B/C.
DR PANTHER; PTHR38498; PTHR38498; 1.
DR Pfam; PF15194; TMEM191C; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..347
FT /note="Transmembrane protein 191C"
FT /id="PRO_0000340717"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 101..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 52..207
FT /evidence="ECO:0000255"
SQ SEQUENCE 347 AA; 39292 MW; 5A85535A1CDB9757 CRC64;
MCRATLGLPL PPIVIQPARR SLPPIVTPAS RRLGPRGGRH LGSVSTAMAA TQELLLQLQK
DNRDGRQRKQ ELEKLMRGLE AESESLNQRL QDLSERERSL LRRRSQAAQP LQGEAREAAR
ERAERVRRRL EEAERHKEYL EQHSRQLQEQ WEELSSQLFY YGGELQSQKS TEQQLAAQLV
TLQNELELAE TKCALQEEKL QQDALQTAEA WAIFQEQTVV LQVRPHSDAK VPPASPPPDL
GRCDGQLRGV QYSTESLMEE MARADRETRL FGGPRALAIR RCVLGALQVL LTLPLLFLGL
SLLWTVLLDP GAVSAWLWSL TSETTLRRLR YTLSPLLELR ANGLLPT
