T191C_MOUSE
ID T191C_MOUSE Reviewed; 302 AA.
AC Q9JJB1; E9Q1C2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2015, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Transmembrane protein 191C {ECO:0000312|MGI:MGI:107238};
GN Name=Tmem191c {ECO:0000312|MGI:MGI:107238}; ORFNames=MNCb-4137;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000305};
CC IsoId=Q9JJB1-1; Sequence=Displayed;
CC Name=2 {ECO:0000305};
CC IsoId=Q9JJB1-2; Sequence=VSP_057637;
CC -!- SIMILARITY: Belongs to the TMEM191 family. {ECO:0000305}.
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DR EMBL; AB041601; BAA95084.1; -; mRNA.
DR EMBL; AC110573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS49776.1; -. [Q9JJB1-1]
DR RefSeq; NP_803424.2; NM_177473.3. [Q9JJB1-1]
DR AlphaFoldDB; Q9JJB1; -.
DR SMR; Q9JJB1; -.
DR STRING; 10090.ENSMUSP00000131127; -.
DR iPTMnet; Q9JJB1; -.
DR PhosphoSitePlus; Q9JJB1; -.
DR PaxDb; Q9JJB1; -.
DR PRIDE; Q9JJB1; -.
DR ProteomicsDB; 254530; -. [Q9JJB1-1]
DR ProteomicsDB; 254531; -. [Q9JJB1-2]
DR Ensembl; ENSMUST00000164950; ENSMUSP00000131127; ENSMUSG00000055692. [Q9JJB1-1]
DR GeneID; 224019; -.
DR KEGG; mmu:224019; -.
DR UCSC; uc007ykp.1; mouse.
DR CTD; 645426; -.
DR MGI; MGI:107238; Tmem191c.
DR VEuPathDB; HostDB:ENSMUSG00000055692; -.
DR eggNOG; ENOG502TDZY; Eukaryota.
DR GeneTree; ENSGT00390000009363; -.
DR HOGENOM; CLU_165590_0_0_1; -.
DR InParanoid; Q9JJB1; -.
DR OMA; AKHAMQA; -.
DR OrthoDB; 1229595at2759; -.
DR TreeFam; TF339530; -.
DR BioGRID-ORCS; 224019; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Tmem191c; mouse.
DR PRO; PR:Q9JJB1; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9JJB1; protein.
DR Bgee; ENSMUSG00000055692; Expressed in utricle of membranous labyrinth and 206 other tissues.
DR ExpressionAtlas; Q9JJB1; baseline and differential.
DR Genevisible; Q9JJB1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028186; TMEM191B/C.
DR PANTHER; PTHR38498; PTHR38498; 1.
DR Pfam; PF15194; TMEM191C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..302
FT /note="Transmembrane protein 191C"
FT /id="PRO_0000340718"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 39..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 5..147
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..181
FT /note="Missing (in isoform 2)"
FT /id="VSP_057637"
SQ SEQUENCE 302 AA; 33974 MW; A5703BA6D9618DB9 CRC64;
MTEPQEQLLQ LQKDNRDGRL RKQELEELVR GLEAESESLT GRLEELRERE RSLQRRRSQA
SRAIRGEACE AARERAERAR GLLEAAEQHR QDLEQHNRKL QEQWEELSSQ LFYYGGEQLS
QQRAEQQLGN QLVALQKHLE LAEAKFSMQA EDLRQGAQRT EEAWASFQEQ SGVLQELQGK
VMEAAAALEA TRGGSEPWNS EPRPVQDCAG SLMEEVARAD CEKRLFGGTG AGSLRLWALS
ALQTLLLLPL GFLVLPLIYV VLAKPDAVGP GLQSLGSDAV FRRLRYTLSP LLELRARGLL
PA
