T198B_DANRE
ID T198B_DANRE Reviewed; 369 AA.
AC Q498W5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Transmembrane protein 198-B;
GN Name=tmem198b; ORFNames=zgc:112212;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM198 family. {ECO:0000305}.
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DR EMBL; BC100048; AAI00049.1; -; mRNA.
DR RefSeq; NP_001029091.1; NM_001033919.1.
DR RefSeq; XP_009300540.1; XM_009302265.2.
DR AlphaFoldDB; Q498W5; -.
DR STRING; 7955.ENSDARP00000043521; -.
DR PaxDb; Q498W5; -.
DR Ensembl; ENSDART00000043522; ENSDARP00000043521; ENSDARG00000034685.
DR Ensembl; ENSDART00000182899; ENSDARP00000155749; ENSDARG00000034685.
DR Ensembl; ENSDART00000185708; ENSDARP00000155265; ENSDARG00000111728.
DR GeneID; 564608; -.
DR KEGG; dre:564608; -.
DR CTD; 440104; -.
DR ZFIN; ZDB-GENE-050809-123; tmem198b.
DR eggNOG; ENOG502QS1E; Eukaryota.
DR GeneTree; ENSGT00390000016940; -.
DR HOGENOM; CLU_043600_0_0_1; -.
DR InParanoid; Q498W5; -.
DR OMA; HPLERRY; -.
DR OrthoDB; 1509246at2759; -.
DR PhylomeDB; Q498W5; -.
DR TreeFam; TF323324; -.
DR PRO; PR:Q498W5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 6.
DR Bgee; ENSDARG00000034685; Expressed in brain and 26 other tissues.
DR ExpressionAtlas; Q498W5; baseline.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR InterPro; IPR025256; DUF4203.
DR InterPro; IPR040236; TMEM198.
DR PANTHER; PTHR31247; PTHR31247; 1.
DR Pfam; PF13886; DUF4203; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..369
FT /note="Transmembrane protein 198-B"
FT /id="PRO_0000326032"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 266..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 369 AA; 40856 MW; 4D4B3565413ECD83 CRC64;
MTSTLQTLAF KLAPPSREAG SGQLEPCSDV QGRRYEVVPS VVCSMCCLFG IIYCFFGYRC
FKAVLFLTGL MFGSVIIFLL CYKERVLDTQ LSVEASVGIG LGIGTLCGLV TMLVRSVGLF
MVGLLLGLLV GIGTLIGMEE LSSNPPRSVW VPLGVLLGLG MLFAVLTLQW QRCFTTLSTA
VFGAAVIVVA TDYFVELFAL VRYIYERVKT GPREPVCWTT WVVLGAWPAL ALLGVLVQWR
VTAEGYSHTK VMISRQQRRV QLMRIRQKEE RRESSRKKKR KQPQSAQHTH AAKALHPEPA
YRRKPNPIRR FDGDVLSPSY IQSFRDRQVD GRAYPVGGLM PSGHTSVDMD YDCGSTVPLT
AGVGPHVRV
