T1LTA_RANLT
ID T1LTA_RANLT Reviewed; 14 AA.
AC C0HLY4;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 1.
DT 03-AUG-2022, entry version 2.
DE RecName: Full=Temporin-1LTa {ECO:0000303|PubMed:27071218};
DE Flags: Fragment;
OS Rana latastei (Italian agile frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX NCBI_TaxID=151453;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, AND AMIDATION AT LEU-14.
RX PubMed=27071218; DOI=10.1002/rcm.7436;
RA Samgina T.Y., Tolpina M.D., Trebse P., Torkar G., Artemenko K.A.,
RA Bergquist J., Lebedev A.T.;
RT "LTQ Orbitrap Velos in routine de novo sequencing of non-tryptic skin
RT peptides from the frog Rana latastei with traditional and reliable manual
RT spectra interpretation.";
RL Rapid Commun. Mass Spectrom. 30:265-276(2016).
CC -!- FUNCTION: Antimicrobial peptide. {ECO:0000250|UniProtKB:C5H0E0}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27071218}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:27071218}.
CC -!- MASS SPECTROMETRY: Mass=1465.93; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:27071218};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Temporin subfamily. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Secreted.
FT CHAIN 1..14
FT /note="Temporin-1LTa"
FT /id="PRO_0000454224"
FT MOD_RES 14
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:27071218"
FT UNSURE 1
FT /note="Assigned by comparison with orthologs"
FT /evidence="ECO:0000305|PubMed:27071218"
FT UNSURE 4
FT /note="Assigned by comparison with orthologs"
FT /evidence="ECO:0000305|PubMed:27071218"
FT UNSURE 7
FT /note="Assigned by comparison with orthologs"
FT /evidence="ECO:0000305|PubMed:27071218"
FT UNSURE 8
FT /note="Assigned by comparison with orthologs"
FT /evidence="ECO:0000305|PubMed:27071218"
FT UNSURE 9
FT /note="Assigned by comparison with orthologs"
FT /evidence="ECO:0000305|PubMed:27071218"
FT UNSURE 11
FT /note="Assigned by comparison with orthologs"
FT /evidence="ECO:0000305|PubMed:27071218"
FT UNSURE 14
FT /note="Assigned by comparison with orthologs"
FT /evidence="ECO:0000305|PubMed:27071218"
FT NON_TER 14
FT /evidence="ECO:0000269|PubMed:27071218"
SQ SEQUENCE 14 AA; 1467 MW; 4F36625B76825B27 CRC64;
LGALTQLLLN LGKL