ID   BP46_BPMU               Reviewed;         145 AA.
AC   Q9T1V3;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   23-FEB-2022, entry version 60.
DE   RecName: Full=Baseplate protein gp46;
DE   AltName: Full=Gene product 46;
DE            Short=gp46;
DE   AltName: Full=Gene product V;
DE            Short=gpV;
GN   OrderedLocusNames=Mup46;
OS   Escherichia phage Mu (Bacteriophage Mu).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Muvirus.
OX   NCBI_TaxID=10677;
OH   NCBI_TaxID=543; Enterobacteriaceae.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11922669; DOI=10.1006/jmbi.2002.5437;
RA   Morgan G.J., Hatfull G.F., Casjens S., Hendrix R.W.;
RT   "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like
RT   prophages in Haemophilus, Neisseria and Deinococcus.";
RL   J. Mol. Biol. 317:337-359(2002).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=3904174; DOI=10.1016/0042-6822(85)90388-5;
RA   Grundy F.J., Howe M.M.;
RT   "Morphogenetic structures present in lysates of amber mutants of
RT   bacteriophage Mu.";
RL   Virology 143:485-504(1985).
RN   [3]
RP   INDUCTION.
RX   PubMed=8293968; DOI=10.1093/genetics/135.3.619;
RA   Chiang L.W., Howe M.M.;
RT   "Mutational analysis of a C-dependent late promoter of bacteriophage Mu.";
RL   Genetics 135:619-629(1993).
RN   [4]
RP   REVIEW.
RX   PubMed=22297511; DOI=10.1007/978-1-4614-0980-9_5;
RA   Leiman P.G., Shneider M.M.;
RT   "Contractile tail machines of bacteriophages.";
RL   Adv. Exp. Med. Biol. 726:93-114(2012).
RN   [5]
RP   SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=27555589; DOI=10.1073/pnas.1607966113;
RA   Buettner C.R., Wu Y., Maxwell K.L., Davidson A.R.;
RT   "Baseplate assembly of phage Mu: Defining the conserved core components of
RT   contractile-tailed phages and related bacterial systems.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:10174-10179(2016).
CC   -!- FUNCTION: Component of the baseplate. Probable connector between the
CC       central and peripheral parts of the baseplate. Probably involved in
CC       tail assembly.
CC   -!- SUBUNIT: Part of a complex composed of three DNA circularization
CC       protein N, three baseplate hub protein gp44 and three sub-complex wedge
CC       (made of two copies of each baseplate protein gp46, gp47 and gp48) that
CC       forms the baseplate. {ECO:0000269|PubMed:27555589}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:27555589}. Host
CC       cytoplasm {ECO:0000305}. Note=Baseplate protein.
CC       {ECO:0000269|PubMed:27555589}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       Expression of late genes is activated by the viral late transcription
CC       activator C. {ECO:0000269|PubMed:8293968}.
CC   -!- DISRUPTION PHENOTYPE: No tail is synthesized.
CC       {ECO:0000269|PubMed:3904174}.
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DR   EMBL; AF083977; AAF01124.1; -; Genomic_DNA.
DR   RefSeq; NP_050650.1; NC_000929.1.
DR   GeneID; 2636291; -.
DR   KEGG; vg:2636291; -.
DR   Proteomes; UP000002611; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0098025; C:virus tail, baseplate; IEA:UniProtKB-KW.
DR   GO; GO:0098003; P:viral tail assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR010877; Phage_Mu_Gp46.
DR   Pfam; PF07409; GP46; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Late protein; Reference proteome; Viral baseplate protein;
KW   Viral release from host cell; Viral tail assembly; Viral tail protein;
KW   Virion.
FT   CHAIN           1..145
FT                   /note="Baseplate protein gp46"
FT                   /id="PRO_0000077840"
SQ   SEQUENCE   145 AA;  16323 MW;  3B65E0D1113E28B7 CRC64;
     MTDLAIIWTN GRGDIAQDGI DMLTDDSLTT DVTISLFTDR RALDSDTLPD GSDDRRGWWG
     DSYRDRPIGS RLWLLSREKA TPDTLERARG YAEEALEWLK TAGRVSAINV RAEQLHQGWL
     YLYIALTLPD GSVIPYEFKA AFNGV