BP48_BPMU
ID BP48_BPMU Reviewed; 180 AA.
AC Q9T1V1;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 23-FEB-2022, entry version 56.
DE RecName: Full=Baseplate protein gp48;
DE AltName: Full=Gene product 48;
DE Short=gp48;
DE AltName: Full=Gene product R;
DE Short=gpR;
GN OrderedLocusNames=Mup48;
OS Escherichia phage Mu (Bacteriophage Mu).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Myoviridae; Muvirus.
OX NCBI_TaxID=10677;
OH NCBI_TaxID=543; Enterobacteriaceae.
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11922669; DOI=10.1006/jmbi.2002.5437;
RA Morgan G.J., Hatfull G.F., Casjens S., Hendrix R.W.;
RT "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like
RT prophages in Haemophilus, Neisseria and Deinococcus.";
RL J. Mol. Biol. 317:337-359(2002).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=3904174; DOI=10.1016/0042-6822(85)90388-5;
RA Grundy F.J., Howe M.M.;
RT "Morphogenetic structures present in lysates of amber mutants of
RT bacteriophage Mu.";
RL Virology 143:485-504(1985).
RN [3]
RP INDUCTION.
RX PubMed=8293968; DOI=10.1093/genetics/135.3.619;
RA Chiang L.W., Howe M.M.;
RT "Mutational analysis of a C-dependent late promoter of bacteriophage Mu.";
RL Genetics 135:619-629(1993).
RN [4]
RP REVIEW.
RX PubMed=22297511; DOI=10.1007/978-1-4614-0980-9_5;
RA Leiman P.G., Shneider M.M.;
RT "Contractile tail machines of bacteriophages.";
RL Adv. Exp. Med. Biol. 726:93-114(2012).
RN [5]
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=27555589; DOI=10.1073/pnas.1607966113;
RA Buettner C.R., Wu Y., Maxwell K.L., Davidson A.R.;
RT "Baseplate assembly of phage Mu: Defining the conserved core components of
RT contractile-tailed phages and related bacterial systems.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:10174-10179(2016).
CC -!- FUNCTION: Component of the baseplate.
CC -!- SUBUNIT: Part of a complex composed of three DNA circularization
CC protein N, three baseplate hub protein gp44 and three sub-complex wedge
CC (made of two copies of each baseplate protein gp46, gp47 and gp48) that
CC forms the baseplate. {ECO:0000269|PubMed:27555589}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:27555589}. Host
CC cytoplasm {ECO:0000305}. Note=Baseplate. {ECO:0000269|PubMed:27555589}.
CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC Expression of late genes is activated by the viral late transcription
CC activator C. {ECO:0000269|PubMed:8293968}.
CC -!- DISRUPTION PHENOTYPE: No tail is synthesized.
CC {ECO:0000269|PubMed:3904174}.
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DR EMBL; AF083977; AAF01126.1; -; Genomic_DNA.
DR RefSeq; NP_050652.1; NC_000929.1.
DR GeneID; 2636277; -.
DR KEGG; vg:2636277; -.
DR Proteomes; UP000002611; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0098025; C:virus tail, baseplate; IEA:UniProtKB-KW.
DR GO; GO:0098003; P:viral tail assembly; IEA:UniProtKB-KW.
DR InterPro; IPR018755; Phage_Mu_Gp48.
DR Pfam; PF10076; DUF2313; 1.
PE 1: Evidence at protein level;
KW Host cytoplasm; Late protein; Reference proteome; Viral baseplate protein;
KW Viral release from host cell; Viral tail assembly; Viral tail protein;
KW Virion.
FT CHAIN 1..180
FT /note="Baseplate protein gp48"
FT /id="PRO_0000077847"
SQ SEQUENCE 180 AA; 20468 MW; 3045A6C185B48BF9 CRC64;
MAVTPWQTAF LQLLPSGLAW NKSPDSKLSA LAQAISDVIA TAADDARQML RERFPSTSRW
YLGEWESFLG LPDCTSENGT LSERQRAAAN KMRMTGNLSR RFYEWLAAQY GFTVRLTDST
EGQWVTQVNI YGIKNYRNAT VLDNVLTPLR VYESGALECL LEKYKPAHQI YKFVYHDGDN
