T1SB_MYCPN
ID T1SB_MYCPN Reviewed; 363 AA.
AC P75279;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Putative type I specificity subunit S.MpnORF507P {ECO:0000303|PubMed:12654995};
DE Short=S protein;
DE Short=S.MpnORF507P {ECO:0000303|PubMed:12654995};
DE AltName: Full=Putative type-1 restriction enzyme specificity subunit MPN_507;
DE AltName: Full=S.MpnORFBP;
GN OrderedLocusNames=MPN_507; ORFNames=MP335, P02_orf363V;
OS Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS pneumoniae).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272634;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129;
RX PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
RN [2]
RP NOMENCLATURE.
RX PubMed=12654995; DOI=10.1093/nar/gkg274;
RA Roberts R.J., Belfort M., Bestor T., Bhagwat A.S., Bickle T.A.,
RA Bitinaite J., Blumenthal R.M., Degtyarev S.K., Dryden D.T., Dybvig K.,
RA Firman K., Gromova E.S., Gumport R.I., Halford S.E., Hattman S.,
RA Heitman J., Hornby D.P., Janulaitis A., Jeltsch A., Josephsen J., Kiss A.,
RA Klaenhammer T.R., Kobayashi I., Kong H., Krueger D.H., Lacks S.,
RA Marinus M.G., Miyahara M., Morgan R.D., Murray N.E., Nagaraja V.,
RA Piekarowicz A., Pingoud A., Raleigh E., Rao D.N., Reich N., Repin V.E.,
RA Selker E.U., Shaw P.C., Stein D.C., Stoddard B.L., Szybalski W.,
RA Trautner T.A., Van Etten J.L., Vitor J.M., Wilson G.G., Xu S.Y.;
RT "A nomenclature for restriction enzymes, DNA methyltransferases, homing
RT endonucleases and their genes.";
RL Nucleic Acids Res. 31:1805-1812(2003).
RN [3]
RP INDUCTION, AND DNA-BINDING.
RC STRAIN=ATCC 29342 / M129;
RX PubMed=23300489; DOI=10.1371/journal.pgen.1003191;
RA Lluch-Senar M., Luong K., Llorens-Rico V., Delgado J., Fang G., Spittle K.,
RA Clark T.A., Schadt E., Turner S.W., Korlach J., Serrano L.;
RT "Comprehensive methylome characterization of Mycoplasma genitalium and
RT Mycoplasma pneumoniae at single-base resolution.";
RL PLoS Genet. 9:e1003191-e1003191(2013).
CC -!- FUNCTION: The specificity (S) subunit of a type I methyltransferase
CC (MTase); this subunit dictates DNA sequence specificity. The single R
CC subunit has multiple frameshifts and is probably not expressed.
CC {ECO:0000303|PubMed:12654995, ECO:0000305|PubMed:8948633}.
CC -!- SUBUNIT: The methyltransferase is composed of M and S polypeptides.
CC {ECO:0000250|UniProtKB:P05719}.
CC -!- INDUCTION: Detected at low levels after 6 and 96 hours growth, there
CC are fewer copies at 96 hours (at protein level).
CC {ECO:0000269|PubMed:23300489}.
CC -!- DOMAIN: Contains two DNA recognition domains, each specifying
CC recognition of one of the two defined components of the target
CC sequence. {ECO:0000250|UniProtKB:P05719}.
CC -!- SIMILARITY: Belongs to the type-I restriction system S methylase
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U00089; AAB95983.1; -; Genomic_DNA.
DR PIR; S73661; S73661.
DR RefSeq; NP_110195.1; NC_000912.1.
DR RefSeq; WP_010874863.1; NC_000912.1.
DR AlphaFoldDB; P75279; -.
DR SMR; P75279; -.
DR IntAct; P75279; 1.
DR STRING; 272634.MPN_507; -.
DR REBASE; 6709; S.MpnORF507P.
DR PRIDE; P75279; -.
DR EnsemblBacteria; AAB95983; AAB95983; MPN_507.
DR KEGG; mpn:MPN_507; -.
DR PATRIC; fig|272634.6.peg.556; -.
DR HOGENOM; CLU_021095_6_0_14; -.
DR OMA; IFANSNW; -.
DR BioCyc; MPNE272634:G1GJ3-830-MON; -.
DR PRO; PR:P75279; -.
DR Proteomes; UP000000808; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.220.20; -; 2.
DR InterPro; IPR000055; Restrct_endonuc_typeI_TRD.
DR InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR Pfam; PF01420; Methylase_S; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Restriction system.
FT CHAIN 1..363
FT /note="Putative type I specificity subunit S.MpnORF507P"
FT /id="PRO_0000198045"
SQ SEQUENCE 363 AA; 42006 MW; 381106066DB1DF1F CRC64;
MQIRTYKIKD ICDIQRGRGI TKEYIKNNSG KYPVYSAATT NNGELGFINT YDFAGEYVTW
TTNGYAGVVF YRNGKFSASQ DCGVLKVRNK EINAQFLAFA LSLKTPQFVH NLGSRPKLNR
KVVAEISLDF PPLEVQEKIA HFLKSFNELS SQLKAELIKR QKQYAFYSDY LLNPKHSQGE
EYKLFKLKDI AKKILVGGEK PSDFQKEKDQ VYKYPILSNS RKADDFLGYS KTFRIAEKSI
TVSARGTIGA VFYRDFSYLP AVSLICFIPK PEFNINFLFH ALKATKFHKQ GSGTGQLTMA
QFKEYQVYIP SLKKQQEIAA TLDPLYYIFA NSNWGIYKEI ELRKKQMQYY QERLFQWIEN
QKV
