ID   T1SF_MYCPN              Reviewed;         238 AA.
AC   Q50287;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Putative type I specificity subunit S.MpnORF201P {ECO:0000303|PubMed:12654995};
DE            Short=S protein;
DE            Short=S.MpnORF201P {ECO:0000303|PubMed:12654995};
DE   AltName: Full=Putative type-1 restriction enzyme specificity subunit MPN_201;
DE   AltName: Full=S.MpnORFFP;
GN   OrderedLocusNames=MPN_201; ORFNames=GT9_orf238, MP630;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8604303; DOI=10.1093/nar/24.4.628;
RA   Hilbert H., Himmelreich R., Plagens H., Herrmann R.;
RT   "Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma
RT   pneumoniae comprising the dnaA region, the atp operon and a cluster of
RT   ribosomal protein genes.";
RL   Nucleic Acids Res. 24:628-639(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=12654995; DOI=10.1093/nar/gkg274;
RA   Roberts R.J., Belfort M., Bestor T., Bhagwat A.S., Bickle T.A.,
RA   Bitinaite J., Blumenthal R.M., Degtyarev S.K., Dryden D.T., Dybvig K.,
RA   Firman K., Gromova E.S., Gumport R.I., Halford S.E., Hattman S.,
RA   Heitman J., Hornby D.P., Janulaitis A., Jeltsch A., Josephsen J., Kiss A.,
RA   Klaenhammer T.R., Kobayashi I., Kong H., Krueger D.H., Lacks S.,
RA   Marinus M.G., Miyahara M., Morgan R.D., Murray N.E., Nagaraja V.,
RA   Piekarowicz A., Pingoud A., Raleigh E., Rao D.N., Reich N., Repin V.E.,
RA   Selker E.U., Shaw P.C., Stein D.C., Stoddard B.L., Szybalski W.,
RA   Trautner T.A., Van Etten J.L., Vitor J.M., Wilson G.G., Xu S.Y.;
RT   "A nomenclature for restriction enzymes, DNA methyltransferases, homing
RT   endonucleases and their genes.";
RL   Nucleic Acids Res. 31:1805-1812(2003).
CC   -!- FUNCTION: The specificity (S) subunit of a type I methyltransferase
CC       (MTase); this subunit dictates DNA sequence specificity. The single R
CC       subunit has multiple frameshifts and is probably not expressed.
CC       {ECO:0000303|PubMed:12654995, ECO:0000305|PubMed:8948633}.
CC   -!- SUBUNIT: The methyltransferase is composed of M and S polypeptides.
CC       {ECO:0000250|UniProtKB:P05719}.
CC   -!- DOMAIN: Contains two DNA recognition domains, each specifying
CC       recognition of one of the two defined components of the target
CC       sequence. {ECO:0000250|UniProtKB:P05719}.
CC   -!- SIMILARITY: Belongs to the type-I restriction system S methylase
CC       family. {ECO:0000305}.
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DR   EMBL; U34795; AAC43680.1; -; Genomic_DNA.
DR   EMBL; U00089; AAB96278.1; -; Genomic_DNA.
DR   PIR; S62809; S62809.
DR   AlphaFoldDB; Q50287; -.
DR   SMR; Q50287; -.
DR   REBASE; 6700; S.MpnORF201P.
DR   EnsemblBacteria; AAB96278; AAB96278; MPN_201.
DR   KEGG; mpn:MPN_201; -.
DR   HOGENOM; CLU_021095_6_2_14; -.
DR   OMA; GHIKDCD; -.
DR   PRO; PR:Q50287; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.220.20; -; 1.
DR   InterPro; IPR000055; Restrct_endonuc_typeI_TRD.
DR   InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR   Pfam; PF01420; Methylase_S; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Restriction system.
FT   CHAIN           1..238
FT                   /note="Putative type I specificity subunit S.MpnORF201P"
FT                   /id="PRO_0000198050"
SQ   SEQUENCE   238 AA;  27550 MW;  2A5188B9DFC701F5 CRC64;
     MAEIPIDFPP LKIQEKIATI LDTFTELRAR KKQYAFYRDY LLNQENIRKI YGANIPFETF
     QVKDICEIRR GRAITKAYIR NNPGENPVYS AATTNDGELG HIKDCDFDGE YITWTTNGYA
     GVVFYRNGKF NASQDCGVLK VKNKKICTKF LSLLLEIEAT KFVHNLASRP KLSQKVMAEI
     ELSFPPLEIQ EKIADILCAF EKLCNDLVEG IPAEIELRKK QLDYYQNFLF NWVQKIRN