T1SI_HAEIN
ID T1SI_HAEIN Reviewed; 385 AA.
AC P71344;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Putative type I restriction enzyme specificity subunit S.HindORF215P {ECO:0000303|PubMed:12654995};
DE Short=S protein;
DE Short=S.HindORF215P {ECO:0000303|PubMed:12654995};
GN OrderedLocusNames=HI_0216;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NOMENCLATURE.
RX PubMed=12654995; DOI=10.1093/nar/gkg274;
RA Roberts R.J., Belfort M., Bestor T., Bhagwat A.S., Bickle T.A.,
RA Bitinaite J., Blumenthal R.M., Degtyarev S.K., Dryden D.T., Dybvig K.,
RA Firman K., Gromova E.S., Gumport R.I., Halford S.E., Hattman S.,
RA Heitman J., Hornby D.P., Janulaitis A., Jeltsch A., Josephsen J., Kiss A.,
RA Klaenhammer T.R., Kobayashi I., Kong H., Krueger D.H., Lacks S.,
RA Marinus M.G., Miyahara M., Morgan R.D., Murray N.E., Nagaraja V.,
RA Piekarowicz A., Pingoud A., Raleigh E., Rao D.N., Reich N., Repin V.E.,
RA Selker E.U., Shaw P.C., Stein D.C., Stoddard B.L., Szybalski W.,
RA Trautner T.A., Van Etten J.L., Vitor J.M., Wilson G.G., Xu S.Y.;
RT "A nomenclature for restriction enzymes, DNA methyltransferases, homing
RT endonucleases and their genes.";
RL Nucleic Acids Res. 31:1805-1812(2003).
CC -!- FUNCTION: A putative specificity subunit for a type I restriction
CC enzyme; the corresponding endonuclease and methylase subunits have
CC multiple frameshifts and are probably not expressed.
CC {ECO:0000303|PubMed:12654995, ECO:0000305}.
CC -!- DOMAIN: Contains two DNA recognition domains, each specifying
CC recognition of one of the two defined components of the target
CC sequence. {ECO:0000250|UniProtKB:P05719}.
CC -!- SIMILARITY: Belongs to the type-I restriction system S methylase
CC family. {ECO:0000305}.
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DR EMBL; L42023; AAC21883.1; -; Genomic_DNA.
DR PIR; E64055; E64055.
DR RefSeq; NP_438384.1; NC_000907.1.
DR RefSeq; WP_005694081.1; NC_000907.1.
DR AlphaFoldDB; P71344; -.
DR SMR; P71344; -.
DR STRING; 71421.HI_0216; -.
DR REBASE; 203442; S1.Lpl434ORF2272P.
DR REBASE; 203808; S.Keu1446ORF916P.
DR REBASE; 6051; S.HindORF215P.
DR EnsemblBacteria; AAC21883; AAC21883; HI_0216.
DR KEGG; hin:HI_0216; -.
DR PATRIC; fig|71421.8.peg.224; -.
DR eggNOG; COG0732; Bacteria.
DR HOGENOM; CLU_021095_6_0_6; -.
DR OMA; ANNIQDY; -.
DR PhylomeDB; P71344; -.
DR BioCyc; HINF71421:G1GJ1-226-MON; -.
DR PRO; PR:P71344; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.220.20; -; 2.
DR InterPro; IPR000055; Restrct_endonuc_typeI_TRD.
DR InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR Pfam; PF01420; Methylase_S; 2.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repeat; Restriction system.
FT CHAIN 1..385
FT /note="Putative type I restriction enzyme specificity
FT subunit S.HindORF215P"
FT /id="PRO_0000198041"
SQ SEQUENCE 385 AA; 44278 MW; AD6A5D037961E62F CRC64;
MKNNRTFLEK LLEGSEVEWK PLDEVANIVN NARKPVKSSL RVSGNIPYYG ANNIQDYVEG
YTHEGEFVLI AEDGSASLEN YSIQWAVGKF WANNHVHVVN GKEKLNNRFL YHYLTNMNFI
PFLAGKERAK LTKAKLQQIP IPIPPLSVQT EIVKILDALT ALTSELTSEL TSELTSELIL
RQKQYEYYRE KLLNIDEMNK VIELGDVGPV RMCKRILKNQ TASSGDIPFY KIGTFGKKPD
AYISNELFQE YKQKYSYPKK GDILISASGT IGRTVIFDGE NSYFQDSNIV WIDNDETLVL
NKYLYHFYKI AKWGIAEGGT IQRLYNDNLK KVKISIPPLK EQHRIVSILD KFETLTNSIT
EGLPLAIEQS QKRYEYYREL LLNFS