ID   T1SX_METJA              Reviewed;         425 AA.
AC   Q58926;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Putative type I restriction enzyme MjaX specificity subunit {ECO:0000305};
DE            Short=S protein;
DE   AltName: Full=Putative type I specificity subunit S.MjaX {ECO:0000303|PubMed:12654995};
DE            Short=S.MjaX {ECO:0000303|PubMed:12654995};
GN   OrderedLocusNames=MJ1531;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=12654995; DOI=10.1093/nar/gkg274;
RA   Roberts R.J., Belfort M., Bestor T., Bhagwat A.S., Bickle T.A.,
RA   Bitinaite J., Blumenthal R.M., Degtyarev S.K., Dryden D.T., Dybvig K.,
RA   Firman K., Gromova E.S., Gumport R.I., Halford S.E., Hattman S.,
RA   Heitman J., Hornby D.P., Janulaitis A., Jeltsch A., Josephsen J., Kiss A.,
RA   Klaenhammer T.R., Kobayashi I., Kong H., Krueger D.H., Lacks S.,
RA   Marinus M.G., Miyahara M., Morgan R.D., Murray N.E., Nagaraja V.,
RA   Piekarowicz A., Pingoud A., Raleigh E., Rao D.N., Reich N., Repin V.E.,
RA   Selker E.U., Shaw P.C., Stein D.C., Stoddard B.L., Szybalski W.,
RA   Trautner T.A., Van Etten J.L., Vitor J.M., Wilson G.G., Xu S.Y.;
RT   "A nomenclature for restriction enzymes, DNA methyltransferases, homing
RT   endonucleases and their genes.";
RL   Nucleic Acids Res. 31:1805-1812(2003).
CC   -!- FUNCTION: A putative specificity (S) subunit of a type I restriction
CC       enzyme thought to recognize 5'-TAGN(6)TGC-3'; the other subunits are
CC       unknown. {ECO:0000303|PubMed:12654995}.
CC   -!- DOMAIN: Contains two DNA recognition domains, each specifying
CC       recognition of one of the two defined components of the target
CC       sequence. {ECO:0000250|UniProtKB:P05719}.
CC   -!- SIMILARITY: Belongs to the type-I restriction system S methylase
CC       family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99552.1; -; Genomic_DNA.
DR   PIR; B64491; B64491.
DR   AlphaFoldDB; Q58926; -.
DR   SMR; Q58926; -.
DR   STRING; 243232.MJ_1531; -.
DR   REBASE; 3899; S.MjaX.
DR   EnsemblBacteria; AAB99552; AAB99552; MJ_1531.
DR   KEGG; mja:MJ_1531; -.
DR   eggNOG; arCOG02626; Archaea.
DR   HOGENOM; CLU_021095_2_1_2; -.
DR   InParanoid; Q58926; -.
DR   OMA; GARRYVY; -.
DR   PhylomeDB; Q58926; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.220.20; -; 2.
DR   InterPro; IPR000055; Restrct_endonuc_typeI_TRD.
DR   InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR   Pfam; PF01420; Methylase_S; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Restriction system.
FT   CHAIN           1..425
FT                   /note="Putative type I restriction enzyme MjaX specificity
FT                   subunit"
FT                   /id="PRO_0000107393"
SQ   SEQUENCE   425 AA;  48889 MW;  DB879AC2D8911AE9 CRC64;
     MVILLQFYKE ENFKKTEIGE IPEDWEVREL KDILEVIRNG LTAKQNKDKI GYPITRIETI
     SDSKIDITKL GYVEDIKQED IAKYRLIIGD ILFSHINSEE HIGKVAIYEG KPEFLLHGMN
     LLLLRPNKNK IEPYYLLYLL RHFKQKNIFK YIAKRAVNQS SINQTQLKHL KIPLPPLEEQ
     KQIAKILSDF DNLIGTINKQ IEVLNKAKKG MMKKLFTKGV FEHKSFKKSE IGEIPEDWEV
     VELGNEKYFK IIMGQSPPSS SYNKEGEGVP FLQGKAEFGN IYPNPVLYTN KPLKVVDDED
     ILISVRAPVG DVNIAPFKLC IGRGLAGIKS NKEKVDNFFV FYYLSYIKPK IEYLGGGAVF
     KAITKKDLES IKIPLPPLEE QKAIAKRLKA IDDLIEIKRK EKEQIEKAKK KIMNLLLTGK
     IRVKT