ID   T1SZ_MYCPN              Reviewed;         187 AA.
AC   P75488;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Putative type I specificity subunit S.MpnORF289P N-terminus {ECO:0000303|PubMed:12654995};
DE            Short=S protein;
DE            Short=S.MpnORF289P N-terminus {ECO:0000303|PubMed:12654995};
DE   AltName: Full=Putative type-1 specificity subunit MPN_289;
DE   AltName: Full=S.MpnORFEBP;
GN   OrderedLocusNames=MPN_289; ORFNames=H10_orf187V, MP546;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=12654995; DOI=10.1093/nar/gkg274;
RA   Roberts R.J., Belfort M., Bestor T., Bhagwat A.S., Bickle T.A.,
RA   Bitinaite J., Blumenthal R.M., Degtyarev S.K., Dryden D.T., Dybvig K.,
RA   Firman K., Gromova E.S., Gumport R.I., Halford S.E., Hattman S.,
RA   Heitman J., Hornby D.P., Janulaitis A., Jeltsch A., Josephsen J., Kiss A.,
RA   Klaenhammer T.R., Kobayashi I., Kong H., Krueger D.H., Lacks S.,
RA   Marinus M.G., Miyahara M., Morgan R.D., Murray N.E., Nagaraja V.,
RA   Piekarowicz A., Pingoud A., Raleigh E., Rao D.N., Reich N., Repin V.E.,
RA   Selker E.U., Shaw P.C., Stein D.C., Stoddard B.L., Szybalski W.,
RA   Trautner T.A., Van Etten J.L., Vitor J.M., Wilson G.G., Xu S.Y.;
RT   "A nomenclature for restriction enzymes, DNA methyltransferases, homing
RT   endonucleases and their genes.";
RL   Nucleic Acids Res. 31:1805-1812(2003).
CC   -!- FUNCTION: The N-terminal section of a specificity (S) subunit of a type
CC       I methyltransferase (MTase); this subunit dictates DNA sequence
CC       specificity. The single R subunit has multiple frameshifts and is
CC       probably not expressed. {ECO:0000303|PubMed:12654995,
CC       ECO:0000305|PubMed:8948633}.
CC   -!- SUBUNIT: The methyltransferase is composed of M and S polypeptides.
CC       {ECO:0000250|UniProtKB:P05719}.
CC   -!- DOMAIN: Contains two DNA recognition domains, each specifying
CC       recognition of one of the two defined components of the target
CC       sequence. {ECO:0000250|UniProtKB:P05719}.
CC   -!- SIMILARITY: Belongs to the type-I restriction system S methylase
CC       family. {ECO:0000305}.
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DR   EMBL; U00089; AAB96194.1; -; Genomic_DNA.
DR   PIR; S73872; S73872.
DR   RefSeq; NP_109977.1; NC_000912.1.
DR   RefSeq; WP_010874646.1; NC_000912.1.
DR   AlphaFoldDB; P75488; -.
DR   SMR; P75488; -.
DR   IntAct; P75488; 1.
DR   STRING; 272634.MPN_289; -.
DR   EnsemblBacteria; AAB96194; AAB96194; MPN_289.
DR   KEGG; mpn:MPN_289; -.
DR   PATRIC; fig|272634.6.peg.313; -.
DR   HOGENOM; CLU_021095_6_2_14; -.
DR   OMA; GQFNATN; -.
DR   BioCyc; MPNE272634:G1GJ3-456-MON; -.
DR   PRO; PR:P75488; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.220.20; -; 1.
DR   InterPro; IPR000055; Restrct_endonuc_typeI_TRD.
DR   InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR   Pfam; PF01420; Methylase_S; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Restriction system.
FT   CHAIN           1..187
FT                   /note="Putative type I specificity subunit S.MpnORF289P N-
FT                   terminus"
FT                   /id="PRO_0000198049"
SQ   SEQUENCE   187 AA;  21289 MW;  610CCDE0592453B6 CRC64;
     MQIKTYKIKD ICDIKRGRVI SKLYIKNNPG EFPVYSSATV NNGEIGRIKD CDLKGEYVTW
     TTDGAQAGSV FYRNGQFNAT NVCGILKVNN DEIYPKFLAY ALRLKAPKFV NYACPIPKLM
     QGTLAEIELD FTSKKIQEKI ATILDTFTEL SAELSAELSA ELSAELRERK KQYVFYSDYL
     LNPKNWK