T200A_DANRE
ID T200A_DANRE Reviewed; 497 AA.
AC Q5RGQ8;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Transmembrane protein 200A;
GN Name=tmem200a; ORFNames=si:ch211-45m15.5;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM200 family. {ECO:0000305}.
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DR EMBL; BX681416; CAI12010.1; -; Genomic_DNA.
DR RefSeq; NP_001038265.1; NM_001044800.1.
DR RefSeq; XP_005160389.1; XM_005160332.3.
DR RefSeq; XP_009292791.1; XM_009294516.2.
DR AlphaFoldDB; Q5RGQ8; -.
DR STRING; 7955.ENSDARP00000126735; -.
DR PaxDb; Q5RGQ8; -.
DR Ensembl; ENSDART00000041250; ENSDARP00000041249; ENSDARG00000031540.
DR Ensembl; ENSDART00000152321; ENSDARP00000126735; ENSDARG00000031540.
DR GeneID; 556369; -.
DR KEGG; dre:556369; -.
DR CTD; 114801; -.
DR ZFIN; ZDB-GENE-040724-81; tmem200a.
DR eggNOG; KOG4823; Eukaryota.
DR GeneTree; ENSGT00530000063698; -.
DR HOGENOM; CLU_030031_0_0_1; -.
DR InParanoid; Q5RGQ8; -.
DR OMA; YWPQKEQ; -.
DR OrthoDB; 564629at2759; -.
DR PhylomeDB; Q5RGQ8; -.
DR TreeFam; TF332635; -.
DR PRO; PR:Q5RGQ8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000031540; Expressed in ganglionic layer of retina and 7 other tissues.
DR ExpressionAtlas; Q5RGQ8; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018787; DUF2371_TMEM200.
DR PANTHER; PTHR31815; PTHR31815; 1.
DR Pfam; PF10177; DUF2371; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..497
FT /note="Transmembrane protein 200A"
FT /id="PRO_0000294342"
FT TOPO_DOM 1..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..497
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 20..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 497 AA; 54970 MW; C052063809E5B9DE CRC64;
MIATGGVITG LAALKRQDST RSQYHLSAQS PGPAPEKKTT KRKPRADVVV VRGKIRLYSA
SGFFLVLGVL ILMAGIAMAV LGYWPHKDQP KAPETKMSAN NTQSFGREQA GSIAQFLEQH
MHSEKMKMLG PFTMGIGIFI FICANAILHE NRDRETKVIH MRDMYSTVID IHSLRIKEQK
CTNGACMGPY GGDTEIRTFG LDSQFASRLA ANTLMSFSGL DGDVRFSHRT SSADDDDGLM
SEARGGFCLL SPTYKDRSEC IFGFQDDGRW EDRRGALKKC QTRSIVSSSI SAFTLPVIKL
NNCVIDEPDI DSITEDLEQS RVHSRPPSME SLTVPVPDIA KAFKPPGVQL LRSNSATESA
SSTSSRSSLS PGSTSGRFLS PGAARKDFGS NNSIHMLSAH SKSLDLERGP TKLTVQPEQR
KHPSWPRLDR SNSKGYTRLE NKEDPMDRLI VPPVDVKKDY TKKEKLLMIS RSHNNLSFEH
DEFMSSGLKR GTSETRF
