T200A_HUMAN
ID T200A_HUMAN Reviewed; 491 AA.
AC Q86VY9; Q96PX5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Transmembrane protein 200A;
GN Name=TMEM200A; Synonyms=KIAA1913; ORFNames=HBE61;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain endothelium;
RA Yonezawa T., Ninomiya Y.;
RT "A novel gene from human brain endothelial cell PCR select library.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=16000565; DOI=10.1158/1078-0432.ccr-05-0128;
RA Hui A.B.Y., Takano H., Lo K.-W., Kuo W.-L., Lam C.N.Y., Tong C.Y.K.,
RA Chang Q., Gray J.W., Ng H.-K.;
RT "Identification of a novel homozygous deletion region at 6q23.1 in
RT medulloblastomas using high-resolution array comparative genomic
RT hybridization analysis.";
RL Clin. Cancer Res. 11:4707-4716(2005).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- INTERACTION:
CC Q86VY9; Q9HD36: BCL2L10; NbExp=3; IntAct=EBI-11732844, EBI-2126349;
CC Q86VY9; P50402: EMD; NbExp=3; IntAct=EBI-11732844, EBI-489887;
CC Q86VY9; Q13432: UNC119; NbExp=3; IntAct=EBI-11732844, EBI-711260;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in cerebellum.
CC {ECO:0000269|PubMed:16000565}.
CC -!- SIMILARITY: Belongs to the TMEM200 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB67806.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB052099; BAD05135.1; -; mRNA.
DR EMBL; AB067500; BAB67806.1; ALT_INIT; mRNA.
DR EMBL; AL137251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC044246; AAH44246.1; -; mRNA.
DR CCDS; CCDS5140.1; -.
DR RefSeq; NP_001245205.1; NM_001258276.1.
DR RefSeq; NP_001245206.1; NM_001258277.1.
DR RefSeq; NP_001245207.1; NM_001258278.1.
DR RefSeq; NP_443145.1; NM_052913.2.
DR RefSeq; XP_005266873.1; XM_005266816.2.
DR RefSeq; XP_011533721.1; XM_011535419.2.
DR RefSeq; XP_016865719.1; XM_017010230.1.
DR AlphaFoldDB; Q86VY9; -.
DR BioGRID; 125362; 47.
DR IntAct; Q86VY9; 15.
DR MINT; Q86VY9; -.
DR STRING; 9606.ENSP00000376224; -.
DR GlyGen; Q86VY9; 1 site.
DR iPTMnet; Q86VY9; -.
DR PhosphoSitePlus; Q86VY9; -.
DR BioMuta; TMEM200A; -.
DR DMDM; 74750476; -.
DR EPD; Q86VY9; -.
DR jPOST; Q86VY9; -.
DR MassIVE; Q86VY9; -.
DR PaxDb; Q86VY9; -.
DR PeptideAtlas; Q86VY9; -.
DR PRIDE; Q86VY9; -.
DR ProteomicsDB; 70091; -.
DR Antibodypedia; 3039; 75 antibodies from 17 providers.
DR DNASU; 114801; -.
DR Ensembl; ENST00000296978.4; ENSP00000296978.3; ENSG00000164484.12.
DR Ensembl; ENST00000392429.1; ENSP00000376224.1; ENSG00000164484.12.
DR Ensembl; ENST00000545622.5; ENSP00000438928.1; ENSG00000164484.12.
DR Ensembl; ENST00000617887.4; ENSP00000480294.1; ENSG00000164484.12.
DR GeneID; 114801; -.
DR KEGG; hsa:114801; -.
DR MANE-Select; ENST00000296978.4; ENSP00000296978.3; NM_001258277.2; NP_001245206.1.
DR UCSC; uc003qca.5; human.
DR CTD; 114801; -.
DR DisGeNET; 114801; -.
DR GeneCards; TMEM200A; -.
DR HGNC; HGNC:21075; TMEM200A.
DR HPA; ENSG00000164484; Tissue enhanced (endometrium).
DR neXtProt; NX_Q86VY9; -.
DR OpenTargets; ENSG00000164484; -.
DR PharmGKB; PA162406349; -.
DR VEuPathDB; HostDB:ENSG00000164484; -.
DR eggNOG; KOG4823; Eukaryota.
DR GeneTree; ENSGT00530000063698; -.
DR HOGENOM; CLU_030031_0_0_1; -.
DR InParanoid; Q86VY9; -.
DR OMA; YWPQKEQ; -.
DR OrthoDB; 564629at2759; -.
DR PhylomeDB; Q86VY9; -.
DR TreeFam; TF332635; -.
DR PathwayCommons; Q86VY9; -.
DR SignaLink; Q86VY9; -.
DR BioGRID-ORCS; 114801; 10 hits in 1063 CRISPR screens.
DR ChiTaRS; TMEM200A; human.
DR GenomeRNAi; 114801; -.
DR Pharos; Q86VY9; Tdark.
DR PRO; PR:Q86VY9; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q86VY9; protein.
DR Bgee; ENSG00000164484; Expressed in secondary oocyte and 148 other tissues.
DR ExpressionAtlas; Q86VY9; baseline and differential.
DR Genevisible; Q86VY9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018787; DUF2371_TMEM200.
DR PANTHER; PTHR31815; PTHR31815; 1.
DR Pfam; PF10177; DUF2371; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..491
FT /note="Transmembrane protein 200A"
FT /id="PRO_0000294340"
FT TOPO_DOM 1..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..126
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..491
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 16..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 350
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 491 AA; 54356 MW; EEFFF8CDAC4DB610 CRC64;
MIATGGVITG LAALKRQDSA RSQQHVNLSP SPATQEKKPI RRRPRADVVV VRGKIRLYSP
SGFFLILGVL ISIIGIAMAV LGYWPQKEHF IDAETTLSTN ETQVIRNEGG VVVRFFEQHL
HSDKMKMLGP FTMGIGIFIF ICANAILHEN RDKETKIIHM RDIYSTVIDI HTLRIKEQRQ
MNGMYTGLMG ETEVKQNGSS CASRLAANTI ASFSGFRSSF RMDSSVEEDE LMLNEGKSSG
HLMPPLLSDS SVSVFGLYPP PSKTTDDKTS GSKKCETKSI VSSSISAFTL PVIKLNNCVI
DEPSIDNITE DADNLKSRSR NLSMDSLVVP LPNTSESFQP VSTVLPRNNS IGESLSSQYK
SSMALGPGAG QLLSPGAARR QFGSNTSLHL LSSHSKSLDL DRGPSTLTVQ AEQRKHPSWP
RLDRNNSKGY MKLENKEDPM DRLLVPQVAI KKDFTNKEKL LMISRSHNNL SFEHDEFLSN
NLKRGTSETR F
