T200A_MOUSE
ID T200A_MOUSE Reviewed; 491 AA.
AC Q8C817; Q69Z67; Q8CCL5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transmembrane protein 200A;
GN Name=Tmem200a; Synonyms=Kiaa1913;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM200 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32577.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK173299; BAD32577.1; ALT_INIT; mRNA.
DR EMBL; AK032569; BAC27929.1; -; mRNA.
DR EMBL; AK048673; BAC33418.1; -; mRNA.
DR CCDS; CCDS23755.1; -.
DR RefSeq; NP_084157.2; NM_029881.3.
DR RefSeq; XP_006512982.1; XM_006512919.3.
DR RefSeq; XP_006512983.1; XM_006512920.2.
DR RefSeq; XP_006512984.1; XM_006512921.3.
DR AlphaFoldDB; Q8C817; -.
DR STRING; 10090.ENSMUSP00000064080; -.
DR GlyGen; Q8C817; 1 site.
DR iPTMnet; Q8C817; -.
DR PhosphoSitePlus; Q8C817; -.
DR PaxDb; Q8C817; -.
DR PRIDE; Q8C817; -.
DR ProteomicsDB; 262991; -.
DR Antibodypedia; 3039; 75 antibodies from 17 providers.
DR DNASU; 77220; -.
DR Ensembl; ENSMUST00000066049; ENSMUSP00000064080; ENSMUSG00000049420.
DR Ensembl; ENSMUST00000218232; ENSMUSP00000151861; ENSMUSG00000049420.
DR GeneID; 77220; -.
DR KEGG; mmu:77220; -.
DR UCSC; uc007erw.2; mouse.
DR CTD; 114801; -.
DR MGI; MGI:1924470; Tmem200a.
DR VEuPathDB; HostDB:ENSMUSG00000049420; -.
DR eggNOG; KOG4823; Eukaryota.
DR GeneTree; ENSGT00530000063698; -.
DR HOGENOM; CLU_030031_0_0_1; -.
DR InParanoid; Q8C817; -.
DR OMA; YWPQKEQ; -.
DR OrthoDB; 564629at2759; -.
DR PhylomeDB; Q8C817; -.
DR TreeFam; TF332635; -.
DR BioGRID-ORCS; 77220; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Tmem200a; mouse.
DR PRO; PR:Q8C817; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8C817; protein.
DR Bgee; ENSMUSG00000049420; Expressed in dorsal pancreas and 119 other tissues.
DR ExpressionAtlas; Q8C817; baseline and differential.
DR Genevisible; Q8C817; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018787; DUF2371_TMEM200.
DR PANTHER; PTHR31815; PTHR31815; 1.
DR Pfam; PF10177; DUF2371; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..491
FT /note="Transmembrane protein 200A"
FT /id="PRO_0000294341"
FT TOPO_DOM 1..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..126
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..491
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 21..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 350
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86VY9"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 194
FT /note="V -> E (in Ref. 2; BAC27929)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 491 AA; 54008 MW; A06DCE2D0CCC9E3B CRC64;
MIATGGVITG LAALKRQDSA RSQQHINLSP LPATQDQKPV RRRPRADVVV VRGKIRLYSP
SGFFLILGVL VSIIGIAMAV LGYWPQKEHF IDAETTLSTN ETQVVRNQGG VVVRFFEQHL
HSDKMKMLGP FTMGIGIFIF ICANAILHEN RDKETKIIHM RDIYSTVIDI HTLRLKEQKQ
ANGLYAGLLG DTEVKQNGSP CASRLAATTL ASFSGMRNSF RVDSSVEEDE LMLTESKSLG
HLMPPLLSDS AVSVFGLYPP PAKATDDKAS SSKKCDTKSI VSSSISAFTL PVIKLNNCVI
DEPSIDSITE VADNLKTRSR NLSMDSLVVP LPSSGESFQP AVTLLPRNNS VGESLSSQYK
SSVALGPGTG QLLSPGAARR QFGSNTSLHL LSSHSKSLDL DRGPSTLTVH AEQRKHPSWP
RLDRSNSKGY MRLENKEDPM DRLLVPQTAI KKDFTNKEKL LMISRSHNNL SFEHDEFLSN
NLKRGTSETR F
