ID   T200B_HUMAN             Reviewed;         307 AA.
AC   Q69YZ2; Q6P2G8; Q6P2Q5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Transmembrane protein 200B;
DE   AltName: Full=Transmembrane protein TTMA;
DE   AltName: Full=Two transmembrane domain-containing family member B;
GN   Name=TMEM200B; Synonyms=TTMB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM200 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL110282; CAH10727.1; -; mRNA.
DR   EMBL; BC064375; AAH64375.2; -; mRNA.
DR   EMBL; BC064538; AAH64538.1; -; mRNA.
DR   EMBL; BC082989; AAH82989.1; -; mRNA.
DR   EMBL; BC110336; AAI10337.1; -; mRNA.
DR   CCDS; CCDS30658.1; -.
DR   RefSeq; NP_001003682.1; NM_001003682.3.
DR   RefSeq; NP_001165339.1; NM_001171868.1.
DR   AlphaFoldDB; Q69YZ2; -.
DR   BioGRID; 134353; 1.
DR   IntAct; Q69YZ2; 2.
DR   MINT; Q69YZ2; -.
DR   STRING; 9606.ENSP00000428544; -.
DR   GlyGen; Q69YZ2; 1 site.
DR   iPTMnet; Q69YZ2; -.
DR   PhosphoSitePlus; Q69YZ2; -.
DR   BioMuta; TMEM200B; -.
DR   DMDM; 74736342; -.
DR   MassIVE; Q69YZ2; -.
DR   PaxDb; Q69YZ2; -.
DR   PeptideAtlas; Q69YZ2; -.
DR   PRIDE; Q69YZ2; -.
DR   ProteomicsDB; 66175; -.
DR   Antibodypedia; 55485; 28 antibodies from 14 providers.
DR   DNASU; 399474; -.
DR   Ensembl; ENST00000420504.2; ENSP00000428544.1; ENSG00000253304.2.
DR   Ensembl; ENST00000521452.2; ENSP00000428459.1; ENSG00000253304.2.
DR   GeneID; 399474; -.
DR   KEGG; hsa:399474; -.
DR   MANE-Select; ENST00000521452.2; ENSP00000428459.1; NM_001003682.4; NP_001003682.1.
DR   UCSC; uc001brn.3; human.
DR   CTD; 399474; -.
DR   GeneCards; TMEM200B; -.
DR   HGNC; HGNC:33785; TMEM200B.
DR   HPA; ENSG00000253304; Tissue enhanced (endometrium).
DR   neXtProt; NX_Q69YZ2; -.
DR   OpenTargets; ENSG00000253304; -.
DR   PharmGKB; PA162406350; -.
DR   VEuPathDB; HostDB:ENSG00000253304; -.
DR   eggNOG; KOG4823; Eukaryota.
DR   GeneTree; ENSGT00530000063698; -.
DR   HOGENOM; CLU_948489_0_0_1; -.
DR   InParanoid; Q69YZ2; -.
DR   OMA; DRKNRSW; -.
DR   OrthoDB; 1246267at2759; -.
DR   PhylomeDB; Q69YZ2; -.
DR   TreeFam; TF332635; -.
DR   PathwayCommons; Q69YZ2; -.
DR   SignaLink; Q69YZ2; -.
DR   BioGRID-ORCS; 399474; 13 hits in 1065 CRISPR screens.
DR   ChiTaRS; TMEM200B; human.
DR   GenomeRNAi; 399474; -.
DR   Pharos; Q69YZ2; Tdark.
DR   PRO; PR:Q69YZ2; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q69YZ2; protein.
DR   Bgee; ENSG00000253304; Expressed in body of uterus and 162 other tissues.
DR   Genevisible; Q69YZ2; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018787; DUF2371_TMEM200.
DR   PANTHER; PTHR31815; PTHR31815; 1.
DR   Pfam; PF10177; DUF2371; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Transmembrane protein 200B"
FT                   /id="PRO_0000317154"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  32750 MW;  A8F7D986A0A773A2 CRC64;
     MTAGSPEECG EVRRSPEGRV SRLGRRLGRR RRPRSPPEPL RVRARLRLRS PSGAFAALGA
     LVVLVGMGIA VAGYWPHRAG APGSRAANAS SPQMSELRRE GRGGGRAHGP HERLRLLGPV
     IMGVGLFVFI CANTLLYENR DLETRRLRQG VLRAQALRPP DGPGWDCALL PSPGPRSPRA
     VGCAEPEIWD PSPRRGTSPV PSVRSLRSEP ANPRLGLPAL LNSYPLKGPG LPPPWGPRTQ
     TGHVIITVQP SGSCIEHSKS LDLGLGELLL GAPAARDCAH RSWPRLDRLS LGGYAKLGGG
     GDLGARV