ID   T200C_HUMAN             Reviewed;         621 AA.
AC   A6NKL6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Transmembrane protein 200C;
DE   AltName: Full=Transmembrane protein TTMA;
DE   AltName: Full=Two transmembrane domain-containing family member A;
GN   Name=TMEM200C; Synonyms=TTMA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA   Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA   Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA   Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA   Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA   Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15722956; DOI=10.1097/00041444-200503000-00007;
RA   Pickard B.S., Malloy M.P., Clark L., Lehellard S., Ewald H.L., Mors O.,
RA   Porteous D.J., Blackwood D.H., Muir W.J.;
RT   "Candidate psychiatric illness genes identified in patients with
RT   pericentric inversions of chromosome 18.";
RL   Psychiatr. Genet. 15:37-44(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM200 family. {ECO:0000305}.
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DR   EMBL; AP005433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK005124; DAA05326.1; -; mRNA.
DR   CCDS; CCDS45825.1; -.
DR   RefSeq; NP_001073678.1; NM_001080209.2.
DR   RefSeq; XP_011524031.1; XM_011525729.2.
DR   AlphaFoldDB; A6NKL6; -.
DR   SMR; A6NKL6; -.
DR   BioGRID; 570397; 4.
DR   IntAct; A6NKL6; 1.
DR   MINT; A6NKL6; -.
DR   STRING; 9606.ENSP00000463375; -.
DR   iPTMnet; A6NKL6; -.
DR   PhosphoSitePlus; A6NKL6; -.
DR   BioMuta; TMEM200C; -.
DR   EPD; A6NKL6; -.
DR   MassIVE; A6NKL6; -.
DR   PaxDb; A6NKL6; -.
DR   PeptideAtlas; A6NKL6; -.
DR   PRIDE; A6NKL6; -.
DR   ProteomicsDB; 1420; -.
DR   Antibodypedia; 66113; 9 antibodies from 5 providers.
DR   DNASU; 645369; -.
DR   Ensembl; ENST00000383490.2; ENSP00000372982.2; ENSG00000206432.4.
DR   Ensembl; ENST00000581347.2; ENSP00000463375.1; ENSG00000206432.4.
DR   GeneID; 645369; -.
DR   KEGG; hsa:645369; -.
DR   MANE-Select; ENST00000383490.3; ENSP00000372982.2; NM_001395400.1; NP_001382329.1.
DR   UCSC; uc002kmx.1; human.
DR   CTD; 645369; -.
DR   DisGeNET; 645369; -.
DR   GeneCards; TMEM200C; -.
DR   HGNC; HGNC:37208; TMEM200C.
DR   HPA; ENSG00000206432; Tissue enhanced (adrenal gland, brain, salivary gland).
DR   neXtProt; NX_A6NKL6; -.
DR   OpenTargets; ENSG00000206432; -.
DR   PharmGKB; PA165429148; -.
DR   VEuPathDB; HostDB:ENSG00000206432; -.
DR   eggNOG; KOG4823; Eukaryota.
DR   GeneTree; ENSGT00530000063698; -.
DR   HOGENOM; CLU_030031_0_0_1; -.
DR   InParanoid; A6NKL6; -.
DR   OMA; YSIYRER; -.
DR   OrthoDB; 565871at2759; -.
DR   PhylomeDB; A6NKL6; -.
DR   TreeFam; TF332635; -.
DR   PathwayCommons; A6NKL6; -.
DR   SignaLink; A6NKL6; -.
DR   BioGRID-ORCS; 645369; 6 hits in 1062 CRISPR screens.
DR   GenomeRNAi; 645369; -.
DR   Pharos; A6NKL6; Tdark.
DR   PRO; PR:A6NKL6; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; A6NKL6; protein.
DR   Bgee; ENSG00000206432; Expressed in endothelial cell and 117 other tissues.
DR   Genevisible; A6NKL6; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018787; DUF2371_TMEM200.
DR   PANTHER; PTHR31815; PTHR31815; 1.
DR   Pfam; PF10177; DUF2371; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..621
FT                   /note="Transmembrane protein 200C"
FT                   /id="PRO_0000348944"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          12..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          284..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          347..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..445
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..494
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..554
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..598
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   621 AA;  63928 MW;  5192A3FA727CAFB7 CRC64;
     MIATGGLLRI SARKQDPLRP PSQIPKRKRK AKKRRKNDVV VVKGKLKLCS ISGLIALCGI
     LVLLVGIAMA VVGYWPKATG TNREGGKQLP PAGSSHRVPT TANSSSSGSK NRSRSHPRAP
     GGVNSSSAGA PRSTPPARAA SPSSSSTSVG FFFRIFSGYL HSDKLKVFGP LIMGIGIFLF
     ICANAVLHEN RDKKTKIINL RDLYSTVIDV HSLRAKDLAA AAAAAAAAAA SSSSSAPAAA
     PPGAIPLNGF LSYVQSRGLE LKPGGCGGSG DAFGAAAMLA KGSWPPHPAA PSGGRPRGAA
     SPPDLASSPR CPREPPSLAE AVYSVYRERS GVAGSRRAAA ATAAAAASSC SSPAPCSPPE
     SWGRQSTASS FVDSSLSAFA LLPLQGGRDR GGDAEGASCS WQRPPGERGS QEIPRGELDL
     SMTNLRGAEG SMRGARREPE EPEGAVAARA ARGQGGRLPR TGRYAALRRR STSGLPDYRA
     PPSPEPPPSP GSADPDSSPL AKAASPSPPL RLEGSPPTRR DSGSSQSDDP SSSNKGYTPL
     REAGTSTESV LDAVAGQTRD SAVAAPVLGA EQSSPEGASQ EPPTAEQPQP VQRQFTNKEK
     LIMISRSHAI GVEEELESTG I