T200_SALTI
ID T200_SALTI Reviewed; 152 AA.
AC P59697; Q57334;
DT 23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2003, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Transposase for insertion sequence element IS200;
GN Name=tnpA1; OrderedLocusNames=STY0437, t2464;
GN and
GN Name=tnpA2; OrderedLocusNames=STY1225, t1735;
GN and
GN Name=tnpA3; OrderedLocusNames=STY1418, t1554;
GN and
GN Name=tnpA4; OrderedLocusNames=STY1580;
GN and
GN Name=tnpA5; OrderedLocusNames=STY1794, t1197;
GN and
GN Name=tnpA6; OrderedLocusNames=STY1844, t1154;
GN and
GN Name=tnpA7; OrderedLocusNames=STY1895, t1105;
GN and
GN Name=tnpA8; OrderedLocusNames=STY2497;
GN and
GN Name=tnpA9; OrderedLocusNames=STY2640, t0456;
GN and
GN Name=tnpA10; OrderedLocusNames=STY3140, t2909;
GN and
GN Name=tnpA11; OrderedLocusNames=STY3154, t2920;
GN and
GN Name=tnpA12; OrderedLocusNames=STY3234, t2995;
GN and
GN Name=tnpA13; OrderedLocusNames=STY3261, t3019;
GN and
GN Name=tnpA14; OrderedLocusNames=STY4765, t4460;
GN and
GN Name=tnpA15; OrderedLocusNames=t2258;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RA Plaschy B., Stanley J., Nicolet J., Burnens A.P.;
RT "Analysis of IS200 insertion loci in Salmonella typhi.";
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Transposase responsible for transposition of the IS200
CC insertion sequence (IS) element. Transposition occurs in 2 main steps,
CC excision from the donor DNA 'top strand' into a single strand circle
CC and its subsequent reinsertion into the DNA target. This increases the
CC copy number of the IS. {ECO:0000250|UniProtKB:Q7DF83}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:Q7DF83};
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q7DF83}.
CC -!- MISCELLANEOUS: Belongs to the IS200/IS605 insertion sequence (IS)
CC element family. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the transposase 17 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y09990; CAA71109.1; -; Genomic_DNA.
DR EMBL; Y09991; CAA71111.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD08855.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD08309.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD01680.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD01828.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD02036.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD02079.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD02126.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD07503.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD07639.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD02825.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD02836.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD02907.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD02931.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD06886.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68168.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68768.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68814.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68853.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO69186.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO69359.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO69860.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70054.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70463.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70474.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70547.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70571.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO71907.1; -; Genomic_DNA.
DR RefSeq; NP_454994.1; NC_003198.1.
DR RefSeq; NP_455678.1; NC_003198.1.
DR RefSeq; NP_455853.1; NC_003198.1.
DR RefSeq; NP_455994.1; NC_003198.1.
DR RefSeq; NP_456194.1; NC_003198.1.
DR RefSeq; NP_456235.1; NC_003198.1.
DR RefSeq; NP_456281.1; NC_003198.1.
DR RefSeq; NP_456816.1; NC_003198.1.
DR RefSeq; NP_456944.1; NC_003198.1.
DR RefSeq; NP_457394.1; NC_003198.1.
DR RefSeq; NP_457405.1; NC_003198.1.
DR RefSeq; NP_457475.1; NC_003198.1.
DR RefSeq; NP_457499.1; NC_003198.1.
DR RefSeq; NP_458843.1; NC_003198.1.
DR RefSeq; WP_000502119.1; NZ_WSUQ01000091.1.
DR AlphaFoldDB; P59697; -.
DR SMR; P59697; -.
DR STRING; 220341.16501668; -.
DR EnsemblBacteria; AAO68168; AAO68168; t0456.
DR EnsemblBacteria; AAO68768; AAO68768; t1105.
DR EnsemblBacteria; AAO68814; AAO68814; t1154.
DR EnsemblBacteria; AAO68853; AAO68853; t1197.
DR EnsemblBacteria; AAO69186; AAO69186; t1554.
DR EnsemblBacteria; AAO69359; AAO69359; t1735.
DR EnsemblBacteria; AAO69860; AAO69860; t2258.
DR EnsemblBacteria; AAO70054; AAO70054; t2464.
DR EnsemblBacteria; AAO70463; AAO70463; t2909.
DR EnsemblBacteria; AAO70474; AAO70474; t2920.
DR EnsemblBacteria; AAO70547; AAO70547; t2995.
DR EnsemblBacteria; AAO70571; AAO70571; t3019.
DR EnsemblBacteria; AAO71907; AAO71907; t4460.
DR GeneID; 66758093; -.
DR KEGG; stt:t0456; -.
DR KEGG; stt:t1105; -.
DR KEGG; stt:t1154; -.
DR KEGG; stt:t1197; -.
DR KEGG; stt:t1554; -.
DR KEGG; stt:t1735; -.
DR KEGG; stt:t2258; -.
DR KEGG; stt:t2464; -.
DR KEGG; stt:t2909; -.
DR KEGG; stt:t2920; -.
DR KEGG; stt:t2995; -.
DR KEGG; stt:t3019; -.
DR KEGG; stt:t4460; -.
DR KEGG; sty:STY0437; -.
DR KEGG; sty:STY1225; -.
DR KEGG; sty:STY1418; -.
DR KEGG; sty:STY1580; -.
DR KEGG; sty:STY1794; -.
DR KEGG; sty:STY1844; -.
DR KEGG; sty:STY1895; -.
DR KEGG; sty:STY2497; -.
DR KEGG; sty:STY2640; -.
DR KEGG; sty:STY3140; -.
DR KEGG; sty:STY3154; -.
DR KEGG; sty:STY3234; -.
DR KEGG; sty:STY3261; -.
DR KEGG; sty:STY4765; -.
DR PATRIC; fig|220341.7.peg.1226; -.
DR eggNOG; COG1943; Bacteria.
DR HOGENOM; CLU_101320_0_0_6; -.
DR OMA; WNCKYHV; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004803; F:transposase activity; IEA:InterPro.
DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:InterPro.
DR Gene3D; 3.30.70.1290; -; 1.
DR InterPro; IPR002686; Transposase_17.
DR InterPro; IPR036515; Transposase_17_sf.
DR Pfam; PF01797; Y1_Tnp; 1.
DR SMART; SM01321; Y1_Tnp; 1.
DR SUPFAM; SSF143422; SSF143422; 1.
PE 3: Inferred from homology;
KW DNA recombination; DNA-binding; Endonuclease; Hydrolase; Magnesium;
KW Metal-binding; Nuclease; Transposable element; Transposition.
FT CHAIN 1..152
FT /note="Transposase for insertion sequence element IS200"
FT /id="PRO_0000075489"
FT ACT_SITE 125
FT /note="Nucleophile"
FT /evidence="ECO:0000250|UniProtKB:Q7DF83"
FT BINDING 61
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250|UniProtKB:Q7DF83"
FT BINDING 63
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250|UniProtKB:Q7DF83"
FT BINDING 129
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250|UniProtKB:Q7DF83"
SQ SEQUENCE 152 AA; 17958 MW; 8389733629EFBC19 CRC64;
MGDEKSLAHT RWNCKYHIVF APKYRRQAFY GEKRRAVGSI LRKLCEWKNV RILEAECCAD
HIHMLLEIPP KMSVSSFMGY LKGKSSLMLY EQFGDLKFKY RNREFWCRGY YVDTVGKNTA
KIQDYIKHQL EEDKMGEQLS IPYPGSPFTG RK
