ID   T214A_XENLA             Reviewed;         681 AA.
AC   A0JMW6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Transmembrane protein 214-A;
GN   Name=tmem214-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Critical mediator, in cooperation with CASP4, of endoplasmic
CC       reticulum-stress induced apoptosis. Required or the activation of CASP4
CC       following endoplasmic reticulum stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Constitutively interacts with CASP4; required for the
CC       localization of procaspase 4 to the ER. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM214 family. {ECO:0000305}.
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DR   EMBL; BC126031; AAI26032.1; -; mRNA.
DR   RefSeq; NP_001090439.1; NM_001096970.1.
DR   AlphaFoldDB; A0JMW6; -.
DR   DNASU; 779351; -.
DR   GeneID; 779351; -.
DR   KEGG; xla:779351; -.
DR   CTD; 779351; -.
DR   Xenbase; XB-GENE-6252459; tmem214.L.
DR   OrthoDB; 1409017at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 779351; Expressed in liver and 19 other tissues.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019308; TMEM214.
DR   PANTHER; PTHR13448; PTHR13448; 1.
DR   Pfam; PF10151; TMEM214; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Endoplasmic reticulum; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..681
FT                   /note="Transmembrane protein 214-A"
FT                   /id="PRO_0000321900"
FT   TRANSMEM        471..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        608..628
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          58..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        300
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        324
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   681 AA;  76871 MW;  A384BF2CD9ED0D0E CRC64;
     MASGAPDGKW KVVKKGKKSG EKGGGRKALS ESNVTPGGTA PIKMANTVYE MGFEQILKKQ
     NKEQVPPNNI PAEQPQKKQQ QQQNPGRKKP QSGDTGSRQR KFHTLEEGLK ALDLAELQRE
     LEKSQNMFPE SPSIWVKDLA GYLNYKLQTV KNDVLIQQSH DYPYCLVNKE LKGIVRSLLA
     KAPHVLDVMV DHCIFSMFQE LDKPTGESLH GYRICLQAVL LDKPKTVTNN LPKYLELLRS
     QVNRPMKCLA VMWAVGQAGF TDLSEGLKVW LGLMFPVLGV KTLTPYAILY LDRLLLAHSN
     LTKGFGMIGP KDFFPLLDFA FMPNNSLTSS QQENLRNLYP RLKVLAFGAT PESTLHTYFP
     SFLSRVTPSC PAEMRKELIN SLTDCLNKDP LSFSVWRQLY TKHLSQSSFL LQHLVETWDS
     NSKAMRKSVR ETVHSFKVTN GEFSGKGSSL KDLEACDAAC QALLHKMKGS GFPWRRLIVI
     AFVFLFGFVF YDVRTHNSFQ ASTSHKVLQQ SGLLSVSQQA WSKVSNYSLQ GQSWLERNVP
     QYYSQAVEVL GPVLEQVWAK TQEGAAYACE KGSVLITYTK DNLPRLIEWL HSHTPDSVCQ
     FIEYLRELLL HLHRTYLLPA VTYLEAAVQN AWQQYVASCN GKVTWDCVRG QVSNISHSSW
     TYLQNTTMTV TNWALSIISH H