ID   T214B_XENLA             Reviewed;         679 AA.
AC   A1L2I9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Transmembrane protein 214-B;
GN   Name=tmem214-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Critical mediator, in cooperation with CASP4, of endoplasmic
CC       reticulum-stress induced apoptosis. Required or the activation of CASP4
CC       following endoplasmic reticulum stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Constitutively interacts with CASP4; required for the
CC       localization of procaspase 4 to the ER. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM214 family. {ECO:0000305}.
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DR   EMBL; BC129551; AAI29552.1; -; mRNA.
DR   RefSeq; NP_001090615.1; NM_001097146.1.
DR   AlphaFoldDB; A1L2I9; -.
DR   GeneID; 100036861; -.
DR   KEGG; xla:100036861; -.
DR   CTD; 100036861; -.
DR   Xenbase; XB-GENE-5827050; tmem214.S.
DR   OrthoDB; 1409017at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 100036861; Expressed in testis and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR019308; TMEM214.
DR   PANTHER; PTHR13448; PTHR13448; 1.
DR   Pfam; PF10151; TMEM214; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Endoplasmic reticulum; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..679
FT                   /note="Transmembrane protein 214-B"
FT                   /id="PRO_0000321901"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        606..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        298
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        322
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   679 AA;  76807 MW;  A1BC9BF17FFFE8CA CRC64;
     MASGAPDGKW KVVKKGKKSG ERREGERKAL TESNVTPGGT APIKMANTVY EMGFDRIHKK
     QNKEQVPPNN MSSEQPQKQQ QNPGKKKPQS GDSVCKQSKF HTLECALKAL DVAELQRDLE
     KSQNMFPENP SIWVKDLAGY LNYKLQTVKN DVLIQQSHDY PYCLINKELK GIVRSLLAKA
     PHVLDVMVDH CIFSMLQELD KPTGESLHGY RICIQAVLLD KPKTVTSNLP KYLELLRSHL
     NRPMKCLTVM WAVGQAGFTD FTEGLKVWLG LMFPVLGVKN LTPYAILYLD RLLLAHSNLT
     KGFGMIGPKD FFPILDFAFM PNNSLTPSQQ ENLRNLYPKL KVLALGATPE STLHTYFPSF
     LSRATPSCPA EMRKELIHSL TDCLNKDSLS FSVWRQLYTK HLSQSSLLLQ HLVETWDSNS
     RAMRKSVRET VHSFKVTNGE FSGKGSSSKD LEACDAACQA LLHKMKSGGF PWWRLIVIAF
     VFLFGSVLYD VRTHNSFQES TSAQILQQSG LLSVSREAWN KVSNYSLQGQ SWLERNVPQY
     YSQAVEVLGP VLEQVWAKTQ EGGAYACEKG SVLLSYAKDN LPRLIEWLHS SIPDSVFQFI
     EYLRELLLHL HQTYLLPAVT YLEAAVQNSW QQYVKSCNGK VTWDCVRGQV GNISHSSWTY
     LQNTTMTFTN WALTIISRH