ID   T217B_HUMAN             Reviewed;         170 AA.
AC   A0A494BZU4;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   05-JUN-2019, sequence version 1.
DT   03-AUG-2022, entry version 13.
DE   RecName: Full=Putative transmembrane protein 217B {ECO:0000305};
DE   Flags: Precursor;
GN   Name=TMEM217B {ECO:0000312|HGNC:HGNC:55922};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- CAUTION: Product of a dubious gene prediction. Found in the 3'UTR of
CC       TMEM217/ AC Q8N7C4. {ECO:0000305}.
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DR   EMBL; AL353579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011512671.1; XM_011514369.2.
DR   RefSeq; XP_011512672.1; XM_011514370.2.
DR   AlphaFoldDB; A0A494BZU4; -.
DR   DNASU; 221468; -.
DR   GeneID; 221468; -.
DR   MANE-Select; ENST00000497775.2; ENSP00000499172.1; NM_001395378.1; NP_001382307.1.
DR   CTD; 221468; -.
DR   GeneCards; ENSG00000286105; -.
DR   HGNC; HGNC:55922; TMEM217B.
DR   VEuPathDB; HostDB:ENSG00000286105; -.
DR   GeneTree; ENSGT00730000111479; -.
DR   OMA; YVGLLCY; -.
DR   ChiTaRS; TMEM217; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000286105; Expressed in left testis and 68 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR027862; DUF4534.
DR   PANTHER; PTHR34928; PTHR34928; 1.
DR   Pfam; PF15049; DUF4534; 1.
PE   5: Uncertain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..170
FT                   /note="Putative transmembrane protein 217B"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5024747049"
FT   TOPO_DOM        22..58
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..120
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..170
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   170 AA;  20067 MW;  B77E7D8EAD55081C CRC64;
     MNVRMFSLMV GIFSVLNTTQ FFIFDLNQKT HICYEAKFSI YVDSKSELVT WTLFHRANIS
     TGLSLTTIII GCFLFYCIHK NIYMGLLIYA MWIITYELIN FSIVLLLNGI IKDHFKTLSY
     LHWIFQISHM LLHFFCLPFI VKHAYNLYKE SQTVGRKRRH RLCSTIAVNS