ID   T225B_HUMAN             Reviewed;         221 AA.
AC   P0DP42;
DT   10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Transmembrane protein 225B {ECO:0000312|HGNC:HGNC:53075};
GN   Name=TMEM225B {ECO:0000312|HGNC:HGNC:53075};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-166.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       P0DP42; O95070: YIF1A; NbExp=3; IntAct=EBI-18398510, EBI-2799703;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AC005020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BI559535; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS87525.1; -.
DR   RefSeq; NP_001182470.1; NM_001195541.2.
DR   RefSeq; NP_001182471.1; NM_001195542.2.
DR   RefSeq; NP_001182472.1; NM_001195543.2.
DR   RefSeq; XP_005250145.1; XM_005250088.4.
DR   RefSeq; XP_011514001.1; XM_011515699.2.
DR   RefSeq; XP_011514002.1; XM_011515700.2.
DR   AlphaFoldDB; P0DP42; -.
DR   SMR; P0DP42; -.
DR   IntAct; P0DP42; 1.
DR   BioMuta; TMEM225B; -.
DR   MassIVE; P0DP42; -.
DR   PeptideAtlas; P0DP42; -.
DR   PRIDE; P0DP42; -.
DR   DNASU; 100289187; -.
DR   Ensembl; ENST00000431679.6; ENSP00000492416.1; ENSG00000244219.7.
DR   Ensembl; ENST00000453227.5; ENSP00000491691.1; ENSG00000244219.7.
DR   GeneID; 100289187; -.
DR   KEGG; hsa:100289187; -.
DR   MANE-Select; ENST00000431679.6; ENSP00000492416.1; NM_001195541.3; NP_001182470.1.
DR   CTD; 100289187; -.
DR   DisGeNET; 100289187; -.
DR   GeneCards; TMEM225B; -.
DR   HGNC; HGNC:53075; TMEM225B.
DR   HPA; ENSG00000244219; Tissue enriched (testis).
DR   neXtProt; NX_P0DP42; -.
DR   OpenTargets; ENSG00000244219; -.
DR   VEuPathDB; HostDB:ENSG00000244219; -.
DR   GeneTree; ENSGT00510000055200; -.
DR   OMA; PQFSVQW; -.
DR   OrthoDB; 1309839at2759; -.
DR   PathwayCommons; P0DP42; -.
DR   BioGRID-ORCS; 100289187; 6 hits in 158 CRISPR screens.
DR   Pharos; P0DP42; Tdark.
DR   PRO; PR:P0DP42; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; P0DP42; protein.
DR   Bgee; ENSG00000244219; Expressed in left testis and 106 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:InterPro.
DR   InterPro; IPR033542; TMEM225.
DR   PANTHER; PTHR36477; PTHR36477; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane.
FT   CHAIN           1..221
FT                   /note="Transmembrane protein 225B"
FT                   /id="PRO_0000440046"
FT   TRANSMEM        14..34
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   221 AA;  25027 MW;  735624504A3C2088 CRC64;
     MLTLEDKDMK GFSWAIVPAL TSLGYLIILV VSIFPFWVRL TNEESHEVFF SGLFENCFNA
     KCWKPRPLSI YIILGRVFLL SAVFLAFVTT FIMMPFASEF FPRTWKQNFV LACISFFTGA
     CAFLALVLHA LEIKALRMKL GPLQFSVLWP YYVLGFGIFL FIVAGTICLI QEMVCPCWHL
     LSTSQSMEED HGSLYLDNLE SLGGEPSSVQ KETQVTAETV I