T229A_HUMAN
ID T229A_HUMAN Reviewed; 380 AA.
AC B2RXF0; A4D0X6;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Transmembrane protein 229A;
GN Name=TMEM229A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM229 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL24328.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236947; EAL24328.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC157828; AAI57829.1; -; mRNA.
DR EMBL; BC171809; AAI71809.1; -; mRNA.
DR CCDS; CCDS47694.1; -.
DR RefSeq; NP_001129474.1; NM_001136002.1.
DR AlphaFoldDB; B2RXF0; -.
DR STRING; 9606.ENSP00000395244; -.
DR iPTMnet; B2RXF0; -.
DR PhosphoSitePlus; B2RXF0; -.
DR BioMuta; TMEM229A; -.
DR MassIVE; B2RXF0; -.
DR PaxDb; B2RXF0; -.
DR PeptideAtlas; B2RXF0; -.
DR PRIDE; B2RXF0; -.
DR ProteomicsDB; 3460; -.
DR Antibodypedia; 55409; 49 antibodies from 11 providers.
DR DNASU; 730130; -.
DR Ensembl; ENST00000455783.3; ENSP00000395244.1; ENSG00000234224.3.
DR GeneID; 730130; -.
DR KEGG; hsa:730130; -.
DR MANE-Select; ENST00000455783.3; ENSP00000395244.1; NM_001136002.2; NP_001129474.1.
DR UCSC; uc011kob.3; human.
DR CTD; 730130; -.
DR GeneCards; TMEM229A; -.
DR HGNC; HGNC:37279; TMEM229A.
DR HPA; ENSG00000234224; Tissue enhanced (brain, intestine, testis).
DR neXtProt; NX_B2RXF0; -.
DR OpenTargets; ENSG00000234224; -.
DR PharmGKB; PA165618420; -.
DR VEuPathDB; HostDB:ENSG00000234224; -.
DR eggNOG; ENOG502QUNK; Eukaryota.
DR GeneTree; ENSGT00390000010899; -.
DR HOGENOM; CLU_048581_0_0_1; -.
DR InParanoid; B2RXF0; -.
DR OMA; FHLVFYP; -.
DR OrthoDB; 1476201at2759; -.
DR PhylomeDB; B2RXF0; -.
DR TreeFam; TF336481; -.
DR PathwayCommons; B2RXF0; -.
DR BioGRID-ORCS; 730130; 8 hits in 1063 CRISPR screens.
DR GenomeRNAi; 730130; -.
DR Pharos; B2RXF0; Tdark.
DR PRO; PR:B2RXF0; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; B2RXF0; protein.
DR Bgee; ENSG00000234224; Expressed in duodenum and 52 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 4.10.20.10; -; 1.
DR InterPro; IPR036963; Tat_dom_sf.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..380
FT /note="Transmembrane protein 229A"
FT /id="PRO_0000391848"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 189
FT /note="Missing (in Ref. 3; AAI71809/AAI57829)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 380 AA; 42370 MW; 5D1C52B9AA449F98 CRC64;
MAGSDVDSEG PARRGGAARR PGAPGGPGSE AAAGCPEPLS TAEAPAESAT LPAWMRLYFY
GMHGITLDVL VSSARRFARS PDLRMLGFSS PYRCLLHSLT HFALEKVYLQ QRRCPNAFVF
NFLLYPSAHV GLQTLAGQAL LLSLGGGAGV AVAPGALDLA LQYVLALYHC QVFLKRFLRL
RYGRQRRRQQ QQQQQQQQQQ RRGALPVPPG ARVPTAAGAR RRRPRGPRGA GGAPSQGLPD
LPRFLFFGMH GFLDEIFFTF FFNVLGQGDG TTSGHTSLWS FFMYGSCSFV VEKLYFHLHY
SRGWGTWKRV PIYVIFIYVW ELSWGLGLRT CGACSWDYSH YPLNFMGLIT LMYLPGWIFL
SVYQDLISNV LWRVQYVPAN
