T229B_HUMAN
ID T229B_HUMAN Reviewed; 167 AA.
AC Q8NBD8;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Transmembrane protein 229B;
GN Name=TMEM229B; Synonyms=C14orf83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NBD8; Q5T8D3-2: ACBD5; NbExp=3; IntAct=EBI-12195227, EBI-10961679;
CC Q8NBD8; Q13520: AQP6; NbExp=3; IntAct=EBI-12195227, EBI-13059134;
CC Q8NBD8; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-12195227, EBI-11343438;
CC Q8NBD8; Q13323: BIK; NbExp=3; IntAct=EBI-12195227, EBI-700794;
CC Q8NBD8; P19397: CD53; NbExp=3; IntAct=EBI-12195227, EBI-6657396;
CC Q8NBD8; P11912: CD79A; NbExp=3; IntAct=EBI-12195227, EBI-7797864;
CC Q8NBD8; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-12195227, EBI-18013275;
CC Q8NBD8; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12195227, EBI-6942903;
CC Q8NBD8; Q15125: EBP; NbExp=3; IntAct=EBI-12195227, EBI-3915253;
CC Q8NBD8; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12195227, EBI-781551;
CC Q8NBD8; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12195227, EBI-18304435;
CC Q8NBD8; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-12195227, EBI-3918971;
CC Q8NBD8; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-12195227, EBI-3917143;
CC Q8NBD8; Q8TED1: GPX8; NbExp=3; IntAct=EBI-12195227, EBI-11721746;
CC Q8NBD8; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-12195227, EBI-18053395;
CC Q8NBD8; P11215: ITGAM; NbExp=3; IntAct=EBI-12195227, EBI-2568251;
CC Q8NBD8; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12195227, EBI-2820517;
CC Q8NBD8; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-12195227, EBI-11956541;
CC Q8NBD8; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-12195227, EBI-373355;
CC Q8NBD8; O14880: MGST3; NbExp=3; IntAct=EBI-12195227, EBI-724754;
CC Q8NBD8; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-12195227, EBI-6163737;
CC Q8NBD8; P15941-11: MUC1; NbExp=3; IntAct=EBI-12195227, EBI-17263240;
CC Q8NBD8; Q9HB07: MYG1; NbExp=3; IntAct=EBI-12195227, EBI-709754;
CC Q8NBD8; O76036-6: NCR1; NbExp=3; IntAct=EBI-12195227, EBI-19157577;
CC Q8NBD8; O14524-2: NEMP1; NbExp=3; IntAct=EBI-12195227, EBI-10969203;
CC Q8NBD8; Q96RD7: PANX1; NbExp=3; IntAct=EBI-12195227, EBI-7037612;
CC Q8NBD8; P57054: PIGP; NbExp=3; IntAct=EBI-12195227, EBI-17630288;
CC Q8NBD8; Q99640-2: PKMYT1; NbExp=3; IntAct=EBI-12195227, EBI-12257782;
CC Q8NBD8; P15151: PVR; NbExp=3; IntAct=EBI-12195227, EBI-3919694;
CC Q8NBD8; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-12195227, EBI-7545592;
CC Q8NBD8; O75396: SEC22B; NbExp=3; IntAct=EBI-12195227, EBI-1058865;
CC Q8NBD8; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-12195227, EBI-18159983;
CC Q8NBD8; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-12195227, EBI-12898013;
CC Q8NBD8; Q8N9I0: SYT2; NbExp=3; IntAct=EBI-12195227, EBI-8032987;
CC Q8NBD8; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-12195227, EBI-12947623;
CC Q8NBD8; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12195227, EBI-8638294;
CC Q8NBD8; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-12195227, EBI-11722971;
CC Q8NBD8; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-12195227, EBI-3923061;
CC Q8NBD8; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-12195227, EBI-12345267;
CC Q8NBD8; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-12195227, EBI-12003468;
CC Q8NBD8; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-12195227, EBI-1059156;
CC Q8NBD8; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-12195227, EBI-744988;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM229 family. {ECO:0000305}.
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DR EMBL; AK090706; BAC03507.1; -; mRNA.
DR EMBL; BC104940; AAI04941.1; -; mRNA.
DR EMBL; BC104942; AAI04943.1; -; mRNA.
DR CCDS; CCDS9783.1; -.
DR RefSeq; NP_001335471.1; NM_001348542.1.
DR RefSeq; NP_001335472.1; NM_001348543.1.
DR RefSeq; NP_001335473.1; NM_001348544.1.
DR RefSeq; NP_001335475.1; NM_001348546.1.
DR RefSeq; NP_001335476.1; NM_001348547.1.
DR RefSeq; NP_001335477.1; NM_001348548.1.
DR RefSeq; NP_001335478.1; NM_001348549.1.
DR RefSeq; NP_872332.1; NM_182526.2.
DR RefSeq; XP_016876542.1; XM_017021053.1.
DR RefSeq; XP_016876544.1; XM_017021055.1.
DR AlphaFoldDB; Q8NBD8; -.
DR BioGRID; 127773; 42.
DR IntAct; Q8NBD8; 42.
DR STRING; 9606.ENSP00000350050; -.
DR BioMuta; TMEM229B; -.
DR DMDM; 74730125; -.
DR MassIVE; Q8NBD8; -.
DR PaxDb; Q8NBD8; -.
DR PeptideAtlas; Q8NBD8; -.
DR PRIDE; Q8NBD8; -.
DR TopDownProteomics; Q8NBD8; -.
DR Antibodypedia; 52317; 5 antibodies from 5 providers.
DR DNASU; 161145; -.
DR Ensembl; ENST00000357461.7; ENSP00000350050.2; ENSG00000198133.9.
DR Ensembl; ENST00000554278.6; ENSP00000452402.2; ENSG00000198133.9.
DR Ensembl; ENST00000554480.6; ENSP00000450859.2; ENSG00000198133.9.
DR Ensembl; ENST00000555638.5; ENSP00000452201.1; ENSG00000198133.9.
DR Ensembl; ENST00000555994.6; ENSP00000452144.2; ENSG00000198133.9.
DR Ensembl; ENST00000557006.6; ENSP00000451774.1; ENSG00000198133.9.
DR GeneID; 161145; -.
DR KEGG; hsa:161145; -.
DR MANE-Select; ENST00000554480.6; ENSP00000450859.2; NM_001348543.2; NP_001335472.1.
DR UCSC; uc001xjj.2; human.
DR CTD; 161145; -.
DR DisGeNET; 161145; -.
DR GeneCards; TMEM229B; -.
DR HGNC; HGNC:20130; TMEM229B.
DR HPA; ENSG00000198133; Tissue enhanced (brain).
DR MIM; 619022; gene.
DR neXtProt; NX_Q8NBD8; -.
DR OpenTargets; ENSG00000198133; -.
DR PharmGKB; PA165479330; -.
DR VEuPathDB; HostDB:ENSG00000198133; -.
DR eggNOG; ENOG502QTFF; Eukaryota.
DR GeneTree; ENSGT00390000010899; -.
DR HOGENOM; CLU_102218_0_0_1; -.
DR InParanoid; Q8NBD8; -.
DR OMA; WDYSQFR; -.
DR OrthoDB; 1476201at2759; -.
DR PhylomeDB; Q8NBD8; -.
DR TreeFam; TF336481; -.
DR PathwayCommons; Q8NBD8; -.
DR SignaLink; Q8NBD8; -.
DR BioGRID-ORCS; 161145; 14 hits in 1061 CRISPR screens.
DR ChiTaRS; TMEM229B; human.
DR GeneWiki; TMEM229B; -.
DR GenomeRNAi; 161145; -.
DR Pharos; Q8NBD8; Tdark.
DR PRO; PR:Q8NBD8; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NBD8; protein.
DR Bgee; ENSG00000198133; Expressed in lateral nuclear group of thalamus and 151 other tissues.
DR ExpressionAtlas; Q8NBD8; baseline and differential.
DR Genevisible; Q8NBD8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR InterPro; IPR010540; CmpB_TMEM229.
DR Pfam; PF06541; ABC_trans_CmpB; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..167
FT /note="Transmembrane protein 229B"
FT /id="PRO_0000263681"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 167 AA; 19531 MW; 0C7507C6F00F0D85 CRC64;
MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNLNWK FPGVTSVWAL FIYGTSILIV
ERMYLRLRGR CPLLLRCLIY TLWTYLWEFT TGFILRQFNA CPWDYSQFDF DFMGLITLEY
AVPWFCGALI MEQFIIRNTL RLRFDKDAEP GEPSGALALA NGHVKTD
